Synthesis, structural characterization, and antimicrobial efficiency of sulfadiazine azo-azomethine dyes and their bi-homonuclear uranyl complexes for chemotherapeutic use

ABDALLA M. KHEDR; Fawaz A. SAAD

doi:https://doi.org/10.3906/kim-1409-21

Makale detayları

Synthesis, structural characterization, and antimicrobial efficiency of sulfadiazine azo-azomethine dyes and their bi-homonuclear uranyl complexes for chemotherapeutic use

Yazarlar:

ABDALLA M. KHEDR | Fawaz A. SAAD

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 2, pp.267-280

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000726911

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1409-21

Özet:

 

Two sulfadiazine azo-azomethine dyes containing two  active coordination centers and their bi-homonuclear UO_2(II)-complexes  were synthesized for potential chemotherapeutic use. The ligands were  prepared, starting from the coupling of sulfadiazine dizonium salt with  acetylacetone, followed by condensation with ethylenediamine and  1,6-hexanediamine (HL^I and HL^{II}) using a modified literature  procedure. The structures of the ligands and their UO_2(II)-complexes  were elucidated by conventional and thermal gravimetric analyses, molar  conductivity, magnetic susceptibility, and IR, UV-Vis, ^1H NMR, and  mass spectra. The analytical and spectral data supported the binuclear  formulation of the complexes with a 2:1 metal to ligand ratio and octahedral  geometry. The molar conductance values of the UO_2(II)-complexes  revealed their nonionic character. The ligands and their complexes were  screened for their antibacterial activities towards the gram-positive  Staphylococcus aureus} and the gram-negativeEscherichia coli, as well as their antifungal activities against  Aspergillus niger and Candida albicans, in order to assess their antimicrobial potential. The results showed  that metallization increases antimicrobial activity compared with the free  ligands.

 

Two sulfadiazine azo-azomethine dyes containing two  active coordination centers and their bi-homonuclear UO_2(II)-complexes  were synthesized for potential chemotherapeutic use. The ligands were  prepared, starting from the coupling of sulfadiazine dizonium salt with  acetylacetone, followed by condensation with ethylenediamine and  1,6-hexanediamine (HL^I and HL^{II}) using a modified literature  procedure. The structures of the ligands and their UO_2(II)-complexes  were elucidated by conventional and thermal gravimetric analyses, molar  conductivity, magnetic susceptibility, and IR, UV-Vis, ^1H NMR, and  mass spectra. The analytical and spectral data supported the binuclear  formulation of the complexes with a 2:1 metal to ligand ratio and octahedral  geometry. The molar conductance values of the UO_2(II)-complexes  revealed their nonionic character. The ligands and their complexes were  screened for their antibacterial activities towards the gram-positive  Staphylococcus aureus} and the gram-negativeEscherichia coli, as well as their antifungal activities against  Aspergillus niger and Candida albicans, in order to assess their antimicrobial potential. The results showed  that metallization increases antimicrobial activity compared with the free  ligands.

Makale detayları

Synthesis, structural characterization, and antimicrobial efficiency of sulfadiazine azo-azomethine dyes and their bi-homonuclear uranyl complexes for chemotherapeutic use

Yazarlar: ABDALLA M. KHEDR | Fawaz A. SAAD

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2015 Vol.39 Issue 2, pp.267-280

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000726911

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1409-21

Sayı

Yazarlar:

ABDALLA M. KHEDR | Fawaz A. SAAD

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 2, pp.267-280

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000726911

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1409-21