Evaluation of Protein C Gene Polymorphism in Patients with Diagnosis of Pulmonary embolism in Turkish Population

Tuba CEVİZ; Nevin KARAKUS; Nursah BASOL; Serbulent YİGİT

doi:https://doi.org/10.5799/jcei.328742

Makale detayları

Evaluation of Protein C Gene Polymorphism in Patients with Diagnosis of Pulmonary embolism in Turkish Population

Yazarlar:

Tuba CEVİZ | Nevin KARAKUS | Nursah BASOL | Serbulent YİGİT

Yayıncı:

Sağlık Araştırmaları Derneği

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Clinical and Experimental Investigations 2017 Vol.8 Issue 1, pp.8-4

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000833166

Sıklık:

Üç Aylık

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/jcei.328742

Özet:

 

Objective: Pulmonary embolism is usually a complication of deep vein thrombosis (DVT) and develops as a result of
obstruction of pulmonary artery and/or branches with pieces that ruptured from the DVT of the leg. Pulmonary embolism
and DVT is also referred as venous thrombo-embolism (VTE), because two events often remain together. In the studies,
it was found that protein C (PROC) deficiency is a risk factor for pulmonary embolism. In this study, we aimed to
evaluate the association between pulmonary embolism and PROC gene -1654C>T polymorphism in Turkish
population.
Methods: The DNAs of 114 pulmonary embolism cases and 120 healthy controls have been analyzed by polymerase
chain reaction (PCR) and restriction fragment length polymorphism (RFLP) to evaluate the relation between PROC
gene -1654C>T polymorphism and pulmonary embolism in our study. Statistical analyses were performed by using chisquare
and analysis of variance tests.
Results: The proportion of individuals with CT genotype carrying polymorphic T allele as heterozygous form was 38.7%
in the control group and 21.9% in the pulmonary embolism cases (p=0.047). When demographic and clinical
characteristics of cases compared with PROC gene -1654C>T polymorphism, it was observed that the changes in
chest CT ratios could be associated with -1654C>T polymorphism (p=0.017).
Conclusion: As a result, individuals with CT genotypes carrying the polymorphic T allele as heterozygous form have
a lower risk of developing pulmonary embolism.

Makale detayları

Evaluation of Protein C Gene Polymorphism in Patients with Diagnosis of Pulmonary embolism in Turkish Population

Yazarlar: Tuba CEVİZ | Nevin KARAKUS | Nursah BASOL | Serbulent YİGİT

Yayıncı: Sağlık Araştırmaları Derneği

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Clinical and Experimental Investigations 2017 Vol.8 Issue 1, pp.8-4

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000833166

Sıklık: Üç Aylık

eISSN: 1309-6621

pISSN: 1309-8578

DOI: https://doi.org/10.5799/jcei.328742

Sayı

Yazarlar:

Tuba CEVİZ | Nevin KARAKUS | Nursah BASOL | Serbulent YİGİT

Yayıncı:

Sağlık Araştırmaları Derneği

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Clinical and Experimental Investigations 2017 Vol.8 Issue 1, pp.8-4

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000833166

Sıklık:

Üç Aylık

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/jcei.328742