Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium

Dilara Örgül

Makale detayları

Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium

Yazarlar:

Dilara Örgül

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.797-807

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346647

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The present work focuses on the inclusion complexations ICs of rosuvastatin calcium RSV with beta  ve gama  derivatives of native cyclodextrins CDs and investigate effects on improved solubility and dissolution rate. The phase solubility studies illustrated that RSV solubility increased in the presence of CD with a negative deviation that indicates AN type diagrams, while βCD showed Bs type, upon addition of βCD, an increase in the solubility of the drug was observed up to a particular point. ICs of RSV were prepared with β and CD by at 1:1, 1:2 and 1:4 different molar ratios by freeze drying method. FT-IR and DSC results revealed formation of ICs between RSV and CD. High drug loading efficiency was obtained for all ICs in the range of 99.41101.84. Water solubility studies showed that βCD ICs have increased solubility of RSV about 1.3 times regardless of CD ratiosp0.05. As compared to βCD ICs, RSV solubility was significantly greater in CD ICs and increased up to 1.45, 1.72 and 2.00 fold at 1:1, 1:2 and 1:4 ratio, respectively. Conspicuously, RSV solubility increased with increasing ratio of CDp0.05. Compared dissolution profiles with pure RSV, all ICs showed improved dissolution rates and immediate release profiles. However multiple point comparison of dissolution profiles indicated that CD ICs have higher drug release. Particularly CD ICs at 1:4 ratio released the highest RSV with 95.12 at 3 min and 100 completion in 15 min. It is concluded that CD provided a better improvement on RSV solubility and dissolution rate than βCD.

 The present work focuses on the inclusion complexations ICs of rosuvastatin calcium RSV with beta  ve gama  derivatives of native cyclodextrins CDs and investigate effects on improved solubility and dissolution rate. The phase solubility studies illustrated that RSV solubility increased in the presence of CD with a negative deviation that indicates AN type diagrams, while βCD showed Bs type, upon addition of βCD, an increase in the solubility of the drug was observed up to a particular point. ICs of RSV were prepared with β and CD by at 1:1, 1:2 and 1:4 different molar ratios by freeze drying method. FT-IR and DSC results revealed formation of ICs between RSV and CD. High drug loading efficiency was obtained for all ICs in the range of 99.41101.84. Water solubility studies showed that βCD ICs have increased solubility of RSV about 1.3 times regardless of CD ratiosp0.05. As compared to βCD ICs, RSV solubility was significantly greater in CD ICs and increased up to 1.45, 1.72 and 2.00 fold at 1:1, 1:2 and 1:4 ratio, respectively. Conspicuously, RSV solubility increased with increasing ratio of CDp0.05. Compared dissolution profiles with pure RSV, all ICs showed improved dissolution rates and immediate release profiles. However multiple point comparison of dissolution profiles indicated that CD ICs have higher drug release. Particularly CD ICs at 1:4 ratio released the highest RSV with 95.12 at 3 min and 100 completion in 15 min. It is concluded that CD provided a better improvement on RSV solubility and dissolution rate than βCD.

 The present work focuses on the inclusion complexations ICs of rosuvastatin calcium RSV with beta  ve gama  derivatives of native cyclodextrins CDs and investigate effects on improved solubility and dissolution rate. The phase solubility studies illustrated that RSV solubility increased in the presence of CD with a negative deviation that indicates AN type diagrams, while βCD showed Bs type, upon addition of βCD, an increase in the solubility of the drug was observed up to a particular point. ICs of RSV were prepared with β and CD by at 1:1, 1:2 and 1:4 different molar ratios by freeze drying method. FT-IR and DSC results revealed formation of ICs between RSV and CD. High drug loading efficiency was obtained for all ICs in the range of 99.41101.84. Water solubility studies showed that βCD ICs have increased solubility of RSV about 1.3 times regardless of CD ratiosp0.05. As compared to βCD ICs, RSV solubility was significantly greater in CD ICs and increased up to 1.45, 1.72 and 2.00 fold at 1:1, 1:2 and 1:4 ratio, respectively. Conspicuously, RSV solubility increased with increasing ratio of CDp0.05. Compared dissolution profiles with pure RSV, all ICs showed improved dissolution rates and immediate release profiles. However multiple point comparison of dissolution profiles indicated that CD ICs have higher drug release. Particularly CD ICs at 1:4 ratio released the highest RSV with 95.12 at 3 min and 100 completion in 15 min. It is concluded that CD provided a better improvement on RSV solubility and dissolution rate than βCD.

 The present work focuses on the inclusion complexations ICs of rosuvastatin calcium RSV with beta  ve gama  derivatives of native cyclodextrins CDs and investigate effects on improved solubility and dissolution rate. The phase solubility studies illustrated that RSV solubility increased in the presence of CD with a negative deviation that indicates AN type diagrams, while βCD showed Bs type, upon addition of βCD, an increase in the solubility of the drug was observed up to a particular point. ICs of RSV were prepared with β and CD by at 1:1, 1:2 and 1:4 different molar ratios by freeze drying method. FT-IR and DSC results revealed formation of ICs between RSV and CD. High drug loading efficiency was obtained for all ICs in the range of 99.41101.84. Water solubility studies showed that βCD ICs have increased solubility of RSV about 1.3 times regardless of CD ratiosp0.05. As compared to βCD ICs, RSV solubility was significantly greater in CD ICs and increased up to 1.45, 1.72 and 2.00 fold at 1:1, 1:2 and 1:4 ratio, respectively. Conspicuously, RSV solubility increased with increasing ratio of CDp0.05. Compared dissolution profiles with pure RSV, all ICs showed improved dissolution rates and immediate release profiles. However multiple point comparison of dissolution profiles indicated that CD ICs have higher drug release. Particularly CD ICs at 1:4 ratio released the highest RSV with 95.12 at 3 min and 100 completion in 15 min. It is concluded that CD provided a better improvement on RSV solubility and dissolution rate than βCD.

Makale detayları

Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium

Yazarlar:

Dilara Örgül

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.797-807

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346647

pISSN:

2630-6344

Rosuvastatin calcium

beta cyclodextrin

gama cyclodextrin

inclusion complexation

dissolution rate

solubility

Sayı

Makale detayları

Comparison the solubility and dissolution rate effects of beta-cyclodextrin and gamma-cyclodextrin complexations of rosuvastatin calcium

Yazarlar: Dilara Örgül

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.28 Issue 3, pp.797-807

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346647

pISSN: 2630-6344

Rosuvastatin calcium

beta cyclodextrin

gama cyclodextrin

inclusion complexation

dissolution rate

solubility

Sayı

Yazarlar:

Dilara Örgül

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.797-807

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346647

pISSN:

2630-6344