Determination of 5-hydroxymethylfurfural (5-HMF) in Expired Pharmaceutical Syrups by Using HPLC-DAD Method

Songül ÜNÜVAR

doi:https://doi.org/10.18596/jotcsa.477710

Makale detayları

Determination of 5-hydroxymethylfurfural (5-HMF) in Expired Pharmaceutical Syrups by Using HPLC-DAD Method

Yazarlar:

Songül ÜNÜVAR

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 3, pp.1431-1440

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000503088

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.477710

Özet:

 


The Maillard reaction product
5-hydroxymethylfurfural (5-HMF) is formed under acidic conditions by the
dehydration of sugars in carbohydrate-based food and pharmaceutical products
during heating and storage. As pharmaceutical syrup formulations contain sugar
and are stored under room temperature, they provide favorable conditions for
the formation of 5-HMF. The long-term storage of syrup bottles after their cap
has been opened and the unintentional use of expired syrups can lead to the
formation of undesirable products such as 5-HMF in medications. Although legal
limits have been established for 5-HMF content in pharmaceutical preparations,
these levels may exceed those limits in hot climates or under inappropriate
storage conditions. The present study detects and measures 5-HMF levels in
expired pharmaceutical syrups through the HPLC-DAD (High Performance Liquid
Chromatography with Diode Array Detection) method, and investigates the effects
on 5-HMF levels of the 72-hour storage of syrups at temperatures of 40˚C. The
5-HMF level in syrups stored at room temperature varied between 1.34 μg/mL to
15.63 μg/mL, while in syrups stored at higher temperatures, the levels ranged
from 2.24 μg/mL to 18.24 μg/mL. This indicated that 5-HMF content in syrups
stored at 40 ˚C was higher than those measured in syrups stored at room
temperature, although the increase was not found to be statistically
significant (p>0.05). In addition to measuring the amount of 5-HMF in
pharmaceutical syrups, this study also examined the changes in the levels of
this dehydration product in syrup formulations under hot climates and according
to storage conditions.


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Makale detayları

Determination of 5-hydroxymethylfurfural (5-HMF) in Expired Pharmaceutical Syrups by Using HPLC-DAD Method

Yazarlar: Songül ÜNÜVAR

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya mühendisliği

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 3, pp.1431-1440

Belge Tipi: Makale

Yayın Tarihi: 8/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000503088

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.477710

Sayı

Yazarlar:

Songül ÜNÜVAR

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya mühendisliği

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2018 Vol.5 Issue 3, pp.1431-1440

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000503088

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.477710