Quantification of MMP-2 and TIMP-1 expressions in breast cancer

Seda Eren Keskin; Deniz Sünnetçi Akkoyunlu; Mehtap Yılmaz; Turgay Şimşek; Sertaç Güler; Naci Çine; Zafer Cantürk; Hakan Savlı

Makale detayları

Quantification of MMP-2 and TIMP-1 expressions in breast cancer

Yazarlar:

Seda Eren Keskin | Deniz Sünnetçi Akkoyunlu | Mehtap Yılmaz | Turgay Şimşek | Sertaç Güler | Naci Çine | Zafer Cantürk | Hakan Savlı

Yayıncı:

Istanbul University

Ana Başlıklar:

Health Care Administration

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.211-218

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001300293

pISSN:

2587-2087

Anahtar kelimeler:

Özet:

 Background and Aims: MMP-2 and TIMP-1 are vital molecules in the remodeling of the extracellular matrix, and they have a critical role in the metastatic process of breast cancer. This study aimed to detect expression levels of MMP-2 and TIMP-1 genes by Quantitative Real-Time Polymerase Chain Reaction qRT-PCR and identify their potential roles in breast cancer prognosis. Methods: MMP-2 and TIMP-1 gene expression levels in 17 breast cancer tumor tissues and normal breast tissue were examined. The expression levels of MMP-2 and TIMP-1 were analyzed by qRT-PCR. The association between the expression levels of MMP-2 and TIMP-1 and clinicopathological manifestations of breast cancer was examined. Results: Lower gene expression levels of MMP-2 and TIMP-1 were detected in tumors compared to the controls. A statistical correlation was not observed between the expression level of MMP-2, TIMP-1, and clinicopathological parameters tumor grade, lymph node involvement, hormone receptor status. Conclusion: Our findings have been suggesting that expression profiles of MMP-2 and TIMP-1 might be independent prognostic and predictive biomarkers for breast cancer. These biomarkers are candidate molecules for personalized therapy. MMP-2 and TIMP-1 expression patterns will also aid in the identification of more precise and targeted subgroups of breast cancer.

 Background and Aims: MMP-2 and TIMP-1 are vital molecules in the remodeling of the extracellular matrix, and they have a critical role in the metastatic process of breast cancer. This study aimed to detect expression levels of MMP-2 and TIMP-1 genes by Quantitative Real-Time Polymerase Chain Reaction qRT-PCR and identify their potential roles in breast cancer prognosis. Methods: MMP-2 and TIMP-1 gene expression levels in 17 breast cancer tumor tissues and normal breast tissue were examined. The expression levels of MMP-2 and TIMP-1 were analyzed by qRT-PCR. The association between the expression levels of MMP-2 and TIMP-1 and clinicopathological manifestations of breast cancer was examined. Results: Lower gene expression levels of MMP-2 and TIMP-1 were detected in tumors compared to the controls. A statistical correlation was not observed between the expression level of MMP-2, TIMP-1, and clinicopathological parameters tumor grade, lymph node involvement, hormone receptor status. Conclusion: Our findings have been suggesting that expression profiles of MMP-2 and TIMP-1 might be independent prognostic and predictive biomarkers for breast cancer. These biomarkers are candidate molecules for personalized therapy. MMP-2 and TIMP-1 expression patterns will also aid in the identification of more precise and targeted subgroups of breast cancer.

 Background and Aims: MMP-2 and TIMP-1 are vital molecules in the remodeling of the extracellular matrix, and they have a critical role in the metastatic process of breast cancer. This study aimed to detect expression levels of MMP-2 and TIMP-1 genes by Quantitative Real-Time Polymerase Chain Reaction qRT-PCR and identify their potential roles in breast cancer prognosis. Methods: MMP-2 and TIMP-1 gene expression levels in 17 breast cancer tumor tissues and normal breast tissue were examined. The expression levels of MMP-2 and TIMP-1 were analyzed by qRT-PCR. The association between the expression levels of MMP-2 and TIMP-1 and clinicopathological manifestations of breast cancer was examined. Results: Lower gene expression levels of MMP-2 and TIMP-1 were detected in tumors compared to the controls. A statistical correlation was not observed between the expression level of MMP-2, TIMP-1, and clinicopathological parameters tumor grade, lymph node involvement, hormone receptor status. Conclusion: Our findings have been suggesting that expression profiles of MMP-2 and TIMP-1 might be independent prognostic and predictive biomarkers for breast cancer. These biomarkers are candidate molecules for personalized therapy. MMP-2 and TIMP-1 expression patterns will also aid in the identification of more precise and targeted subgroups of breast cancer.

 Background and Aims: MMP-2 and TIMP-1 are vital molecules in the remodeling of the extracellular matrix, and they have a critical role in the metastatic process of breast cancer. This study aimed to detect expression levels of MMP-2 and TIMP-1 genes by Quantitative Real-Time Polymerase Chain Reaction qRT-PCR and identify their potential roles in breast cancer prognosis. Methods: MMP-2 and TIMP-1 gene expression levels in 17 breast cancer tumor tissues and normal breast tissue were examined. The expression levels of MMP-2 and TIMP-1 were analyzed by qRT-PCR. The association between the expression levels of MMP-2 and TIMP-1 and clinicopathological manifestations of breast cancer was examined. Results: Lower gene expression levels of MMP-2 and TIMP-1 were detected in tumors compared to the controls. A statistical correlation was not observed between the expression level of MMP-2, TIMP-1, and clinicopathological parameters tumor grade, lymph node involvement, hormone receptor status. Conclusion: Our findings have been suggesting that expression profiles of MMP-2 and TIMP-1 might be independent prognostic and predictive biomarkers for breast cancer. These biomarkers are candidate molecules for personalized therapy. MMP-2 and TIMP-1 expression patterns will also aid in the identification of more precise and targeted subgroups of breast cancer.

Makale detayları

Quantification of MMP-2 and TIMP-1 expressions in breast cancer

Yazarlar:

Seda Eren Keskin | Deniz Sünnetçi Akkoyunlu | Mehtap Yılmaz | Turgay Şimşek | Sertaç Güler | Naci Çine | Zafer Cantürk | Hakan Savlı

Yayıncı:

Istanbul University

Ana Başlıklar:

Health Care Administration

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.211-218

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001300293

pISSN:

2587-2087

Breast cancer

MMP2 metalloproteinase

TIMP-1

Sayı

Makale detayları

Quantification of MMP-2 and TIMP-1 expressions in breast cancer

Yazarlar: Seda Eren Keskin | Deniz Sünnetçi Akkoyunlu | Mehtap Yılmaz | Turgay Şimşek | Sertaç Güler | Naci Çine | Zafer Cantürk | Hakan Savlı

Yayıncı: Istanbul University

Ana Başlıklar: Health Care Administration

Dergi: İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.211-218

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001300293

pISSN: 2587-2087

Breast cancer

MMP2 metalloproteinase

TIMP-1

Sayı

Yazarlar:

Seda Eren Keskin | Deniz Sünnetçi Akkoyunlu | Mehtap Yılmaz | Turgay Şimşek | Sertaç Güler | Naci Çine | Zafer Cantürk | Hakan Savlı

Yayıncı:

Istanbul University

Ana Başlıklar:

Health Care Administration

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.211-218

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001300293

pISSN:

2587-2087