Investigation of Blood Natural Killer Cell Activity in Normozoospermic Fertile, Oligozoospermic, Severe-Oligozoospermic, Oligoastenozoospermic, Azoospermic and Idiopathic Individuals

M. Ferit Özmen; Muhamet Afşin; Uğur Şeker; Dilek Yavuz; Muhammed Hanifi Bademkıran; Ümüt Cirit; İbrahim Yıldırım

Makale detayları

Investigation of Blood Natural Killer Cell Activity in Normozoospermic Fertile, Oligozoospermic, Severe-Oligozoospermic, Oligoastenozoospermic, Azoospermic and Idiopathic Individuals

Yazarlar:

M. Ferit Özmen | Muhamet Afşin | Uğur Şeker | Dilek Yavuz | Muhammed Hanifi Bademkıran | Ümüt Cirit | İbrahim Yıldırım

Yayıncı:

Mardin Artuklu University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Artuklu International Journal of Health Sciences Vol.3 Issue 2, pp.218-221

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296884

pISSN:

2792-0321

Anahtar kelimeler:

Özet:

 Introduction: Infertility is a health problem that negatively affects couples and society in many ways and is becoming increasingly common. It is estimated that 30-40 of these problems are caused by men. It was aimed to determine whether natural killer Natural Killer: NK cell activity changes in male individuals with different degrees of infertility problems and in individuals with normal sperm count and concentration normozoospermia. Methods: NK cell activities were measured from blood samples taken from individuals who were determined to be oligozoospermia, severe-oligozoospermia, oligoastenoozospermia, azoospermia and idiopathic as a result of semen analysis with from individuals diagnosed normozoospermia n:120. Results: NK cell activity in blood was observed as the lowest in normozoospermia 544.46 pgml, but the highest value measured in severe oligozoospermia group 1005.90 pgml. On the other hand, NK cell activity was measured 797.60  428.55 pgml, 905.34  430.60 pgml, 757.66  541.16 pgml and 639.44  385.50 pgml in oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic groups respectively. While the difference in NK activity between the severe oligozospermia group and the other groups was significant p0.05, the differences between the other groups were not significant p 0.05. Conclusion: It was determined that NK cell activity was higher in individuals with severe oligozoospermia than normozoospermia, oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic individuals.

 Introduction: Infertility is a health problem that negatively affects couples and society in many ways and is becoming increasingly common. It is estimated that 30-40 of these problems are caused by men. It was aimed to determine whether natural killer Natural Killer: NK cell activity changes in male individuals with different degrees of infertility problems and in individuals with normal sperm count and concentration normozoospermia. Methods: NK cell activities were measured from blood samples taken from individuals who were determined to be oligozoospermia, severe-oligozoospermia, oligoastenoozospermia, azoospermia and idiopathic as a result of semen analysis with from individuals diagnosed normozoospermia n:120. Results: NK cell activity in blood was observed as the lowest in normozoospermia 544.46 pgml, but the highest value measured in severe oligozoospermia group 1005.90 pgml. On the other hand, NK cell activity was measured 797.60  428.55 pgml, 905.34  430.60 pgml, 757.66  541.16 pgml and 639.44  385.50 pgml in oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic groups respectively. While the difference in NK activity between the severe oligozospermia group and the other groups was significant p0.05, the differences between the other groups were not significant p 0.05. Conclusion: It was determined that NK cell activity was higher in individuals with severe oligozoospermia than normozoospermia, oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic individuals.

 Introduction: Infertility is a health problem that negatively affects couples and society in many ways and is becoming increasingly common. It is estimated that 30-40 of these problems are caused by men. It was aimed to determine whether natural killer Natural Killer: NK cell activity changes in male individuals with different degrees of infertility problems and in individuals with normal sperm count and concentration normozoospermia. Methods: NK cell activities were measured from blood samples taken from individuals who were determined to be oligozoospermia, severe-oligozoospermia, oligoastenoozospermia, azoospermia and idiopathic as a result of semen analysis with from individuals diagnosed normozoospermia n:120. Results: NK cell activity in blood was observed as the lowest in normozoospermia 544.46 pgml, but the highest value measured in severe oligozoospermia group 1005.90 pgml. On the other hand, NK cell activity was measured 797.60  428.55 pgml, 905.34  430.60 pgml, 757.66  541.16 pgml and 639.44  385.50 pgml in oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic groups respectively. While the difference in NK activity between the severe oligozospermia group and the other groups was significant p0.05, the differences between the other groups were not significant p 0.05. Conclusion: It was determined that NK cell activity was higher in individuals with severe oligozoospermia than normozoospermia, oligozoospermia, oligoastenozoospermia, azoospermia and idiopathic individuals.

 Giriş: İnfertilite çiftleri ve toplumu birçok açıdan olumsuz etkileyen ve gittikçe yaygınlaşan bir sağlık problemidir. Bu problemlerin 30-40ının erkek kaynaklı olduğu tahmin edilmektedir. Farklı derecelerde infertilite problemi olan erkek bireyler ile normal sperm sayısı ve konsantrasyonuna sahip bireylerde normozoospermi doğal öldurucu Natural Killer: NK hucre aktivitesinin değişip değişmediğinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Sperma analizleri sonucu oligozoospermi, şiddetli-oligozoospermi, oligoastenoozospermi, azoospermi ve idiopatik olduğu belirlenen bireyler ile normozoospermi teşhisi konan bireylerden n:120 alınan kan numunelerinden NK hucre aktiviteleri ölçuldu. Bulgular: Yapılan ölçumler sonucunda normozoospermi grubu en duşuk değer 544.46 pgml alırken şiddetli oligozoospermi grubundan en yuksek değer 1005.90 pgml alınmıştır. NK hucre aktivitesi ise oligozoospermi, oligoastenozoospermi, azoospermi ve idiyopatik gruplarda sırasıyla 797.60  428.55 pgml, 905.34  430.60 pgml, 757.66  541.16 pgml ve 639.44  385.50 pgml olarak ölçuldu. Şiddetli oligozoospermi grubu ile diğer gruplar arasında NK aktivitesi farkı önemli p0.05 bulunurken diğer gruplar arasındaki farklar önemli bulunmamıştır p 0.05. Sonuç: İnfertilite derecesi şiddetli oligozoospermi olan bireylerde NK hucre aktivitesinin normozoospermi, oligozoospermi, oligoastenozoospermi, azoospermi ve idiopatik gruplarından daha yuksek olduğu belirlenmiştir.

Makale detayları

Investigation of Blood Natural Killer Cell Activity in Normozoospermic Fertile, Oligozoospermic, Severe-Oligozoospermic, Oligoastenozoospermic, Azoospermic and Idiopathic Individuals

Yazarlar:

M. Ferit Özmen | Muhamet Afşin | Uğur Şeker | Dilek Yavuz | Muhammed Hanifi Bademkıran | Ümüt Cirit | İbrahim Yıldırım

Yayıncı:

Mardin Artuklu University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Artuklu International Journal of Health Sciences Vol.3 Issue 2, pp.218-221

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296884

pISSN:

2792-0321

Infertility

NK activity

Normozoospermia

Severe oligozoospermiaİnfertilite

NK aktivitesi

Normozoospermi

Şiddetli oligozoospermi

Sayı

Makale detayları

Yazarlar: M. Ferit Özmen | Muhamet Afşin | Uğur Şeker | Dilek Yavuz | Muhammed Hanifi Bademkıran | Ümüt Cirit | İbrahim Yıldırım

Yayıncı: Mardin Artuklu University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Artuklu International Journal of Health Sciences Vol.3 Issue 2, pp.218-221

Belge Tipi: Makale

Yayın Tarihi: 11/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001296884

pISSN: 2792-0321

Sayı

Yazarlar:

M. Ferit Özmen | Muhamet Afşin | Uğur Şeker | Dilek Yavuz | Muhammed Hanifi Bademkıran | Ümüt Cirit | İbrahim Yıldırım

Yayıncı:

Mardin Artuklu University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Artuklu International Journal of Health Sciences Vol.3 Issue 2, pp.218-221

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296884

pISSN:

2792-0321