An exploration of new avenues regarding deep tissue penetration and higher   singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic   therapy

Nisa YEŞİLGÜL; Bilal KILIÇ

Makale detayları

An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Yazarlar:

Nisa YEŞİLGÜL | Bilal KILIÇ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 2, pp.624-633

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000725813

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A series of novel BODIPY-bearing electron-withdrawing   groups at the meso position are reported here. According to the optical   measurements, it may be clearly seen that the introduction of   electron-donating groups into 3,5-positions and the presence of   electron-withdrawing groups at the meso position of the BODIPY core resulted   in spectacular bathochromic shifts (up to ∼ 304 nm), and the   projected photosensitizers had absorption bands in the therapeutic window of   the electromagnetic spectrum (600-900 nm). The absorption maxima of   compounds 4,5,6, and 7 were at 886 nm,   890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation   experiments revealed that compounds 6 and 7, with   high singlet oxygen quantum yields (0.52 and 0.93, respectively), were   excellent and promising candidates for photodynamic therapy. The singlet   oxygen quantum yield of 0.93 was the highest reported value so far for   BODIPY-based photosensitizers.

Makale detayları

An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Yazarlar: Nisa YEŞİLGÜL | Bilal KILIÇ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2019 Vol.43 Issue 2, pp.624-633

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000725813

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Nisa YEŞİLGÜL | Bilal KILIÇ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 2, pp.624-633

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000725813

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527