The Role of Triglyceride/Glucose Index in Determining Insulin Resistance in Patients Diagnosed with Hypertension

Muhammet Yıldız; Habibe İnci; Burcu Korkut; Pınar Kalem; Aysegul Ertınmaz Ozkan; Didem Adahan

Makale detayları

The Role of Triglyceride/Glucose Index in Determining Insulin Resistance in Patients Diagnosed with Hypertension

Yazarlar:

Muhammet Yıldız | Habibe İnci | Burcu Korkut | Pınar Kalem | Aysegul Ertınmaz Ozkan | Didem Adahan

Yayıncı:

Karabuk University

Ana Başlıklar:

Halk Sağlığı (Diğer)

Dergi:

Unika Sağlık Bilimleri Dergisi Vol.4 Issue 1, pp.652-660

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001315801

pISSN:

2757-6817

Anahtar kelimeler:

Özet:

 Objective: In this study, we aimed to determine the role of Triglyceride-Glucose Index TyG in detecting insulin resistance in hypertension HT patients followed up in primary care, especially in centers where blood insulin levels cannot be checked. Methods: This study is cross-sectional. The study was conducted with 458 people aged 18-65 who applied to the internal medicine outpatient clinics of the university hospital between January 2020 and January 2022. 285 of the individuals formed the patient group and 173 constituted the control group. Participants diagnosed with chronic diseases other than hypertension and receiving medical treatment due to insulin resistance were excluded from the study. Sociodemographic characteristics of the individuals, fasting blood sugar, triglyceride TG, alanine aminotransferase test ALT, aspartate aminotransferase test AST, creatinine, glycated hemoglobin HbA1c, insulin and thyroid stimulating hormone TSH values and anthropometric measurements were taken from the hospital automation system. Results: The mean age of 285person HT patients and 173person control group was 52.8212.60 and 50.6513.04, respectively. 60.4 of the HT patient group and 59.5 of the control group were female. In HT patients with a HOMA-IR value of 2.5, the cut-off point for TyG value was found to be 4.78, with a sensitivity of 69.1, specificity of 74.7, area under the ROC curve  standard error under the ROC curve AUCSE 0.7590.030 p0.001. Univariate regression analysis showed that a 1-unit increase in TyG increased the risk of hypertension 7.21-fold and this increase was statistically significant p0.001. Conclusion: In this study, it was determined that the TyG index can be used to calculate insulin resistance as a parameter that will affect the prognosis in patients diagnosed with hypertension. The study is important research that points out that TyG can be used as an alternative to HOMA-IR, especially in family health centers.

 Objective: In this study, we aimed to determine the role of Triglyceride-Glucose Index TyG in detecting insulin resistance in hypertension HT patients followed up in primary care, especially in centers where blood insulin levels cannot be checked. Methods: This study is cross-sectional. The study was conducted with 458 people aged 18-65 who applied to the internal medicine outpatient clinics of the university hospital between January 2020 and January 2022. 285 of the individuals formed the patient group and 173 constituted the control group. Participants diagnosed with chronic diseases other than hypertension and receiving medical treatment due to insulin resistance were excluded from the study. Sociodemographic characteristics of the individuals, fasting blood sugar, triglyceride TG, alanine aminotransferase test ALT, aspartate aminotransferase test AST, creatinine, glycated hemoglobin HbA1c, insulin and thyroid stimulating hormone TSH values and anthropometric measurements were taken from the hospital automation system. Results: The mean age of 285person HT patients and 173person control group was 52.8212.60 and 50.6513.04, respectively. 60.4 of the HT patient group and 59.5 of the control group were female. In HT patients with a HOMA-IR value of 2.5, the cut-off point for TyG value was found to be 4.78, with a sensitivity of 69.1, specificity of 74.7, area under the ROC curve  standard error under the ROC curve AUCSE 0.7590.030 p0.001. Univariate regression analysis showed that a 1-unit increase in TyG increased the risk of hypertension 7.21-fold and this increase was statistically significant p0.001. Conclusion: In this study, it was determined that the TyG index can be used to calculate insulin resistance as a parameter that will affect the prognosis in patients diagnosed with hypertension. The study is important research that points out that TyG can be used as an alternative to HOMA-IR, especially in family health centers.

 Objective: In this study, we aimed to determine the role of Triglyceride-Glucose Index TyG in detecting insulin resistance in hypertension HT patients followed up in primary care, especially in centers where blood insulin levels cannot be checked. Methods: This study is cross-sectional. The study was conducted with 458 people aged 18-65 who applied to the internal medicine outpatient clinics of the university hospital between January 2020 and January 2022. 285 of the individuals formed the patient group and 173 constituted the control group. Participants diagnosed with chronic diseases other than hypertension and receiving medical treatment due to insulin resistance were excluded from the study. Sociodemographic characteristics of the individuals, fasting blood sugar, triglyceride TG, alanine aminotransferase test ALT, aspartate aminotransferase test AST, creatinine, glycated hemoglobin HbA1c, insulin and thyroid stimulating hormone TSH values and anthropometric measurements were taken from the hospital automation system. Results: The mean age of 285person HT patients and 173person control group was 52.8212.60 and 50.6513.04, respectively. 60.4 of the HT patient group and 59.5 of the control group were female. In HT patients with a HOMA-IR value of 2.5, the cut-off point for TyG value was found to be 4.78, with a sensitivity of 69.1, specificity of 74.7, area under the ROC curve  standard error under the ROC curve AUCSE 0.7590.030 p0.001. Univariate regression analysis showed that a 1-unit increase in TyG increased the risk of hypertension 7.21-fold and this increase was statistically significant p0.001. Conclusion: In this study, it was determined that the TyG index can be used to calculate insulin resistance as a parameter that will affect the prognosis in patients diagnosed with hypertension. The study is important research that points out that TyG can be used as an alternative to HOMA-IR, especially in family health centers.

 Amaç: Bu çalışmada; kan insülin düzeyine bakılamayan merkezlerde özellikle birinci basamakta takip edilen hipertansiyon HT hastalarında insülin direncini tespit etmede Trigliserit-Glukoz İndeksinin TyG rolünün belirlenmesi amaçlandı. Gereç ve Yöntem: Bu çalışma kesitsel özelliktedir. Ocak 2020-Ocak 2022 tarihleri arasında üniversite hastanesi iç hastalıkları polikliniklerine başvurmuş, 18-65 yaş arasındaki 458 kişi ile çalışma yapıldı. Bireylerin 285 i hasta grubunu, 173 ü kontrol grubunu oluşturdu. Hipertansiyon dışında kronik hastalık tanısı alan ve insülin direnci nedeniyle medikal tedavi alan katılımcılar çalışma dışı bırakıldı. Bireylerin sosyodemografik özellikleri, açlık kan şekeri, trigliserit TG, alanin aminotransferaz testi ALT, aspartat aminotransferaz testi AST, kreatinin, glikozillenmiş hemoglobin HbA1c, insülin ve tiroit stimülan hormon TSH değerleri ile antropometrik ölçümleri hastane otomasyon sisteminden alındı. Bulgular: Çalışmada 285kişi HT hastasının yaş ortalaması; 52,8212,60, 173kişi kontrol grubunun 50,6513,04tü. HT hasta grubunun 60,4ü, kontrol grubunun 59,5i kadındı. HOMA-IR değeri 2,5 olan HT hastalarında TyG değeri için kesim noktası 4,78 olarak saptanmış olup duyarlılık 69,1, özgüllük 74,7, ROC eğrisi altındaki alan  standart hata AUCSE 0,7590,030 p0,001 olarak bulundu. Yapılan tek değişkenli regresyon analizlerinde TyG değerindeki 1 birimlik artışın hipertansiyon riskini 7,21 kat arttırdığı ve bu artışın istatistiksel olarak anlamlı olduğu tespit edildi p0,001. Sonuç: Bu çalışmada TyG indeksinin hipertansiyon tanısı almış hastalarda prognozu etkileyecek bir parametre olarak insülin direncini hesaplamada kullanılabileceği saptandı. Çalışma TyGnin özellikle aile sağlığı merkezlerinde HOMA-IRye alternatif olarak kullanılabileceğine dikkat çeken önemli bir araştırmadır.

Makale detayları

The Role of Triglyceride/Glucose Index in Determining Insulin Resistance in Patients Diagnosed with Hypertension

Yazarlar:

Muhammet Yıldız | Habibe İnci | Burcu Korkut | Pınar Kalem | Aysegul Ertınmaz Ozkan | Didem Adahan

Yayıncı:

Karabuk University

Ana Başlıklar:

Halk Sağlığı (Diğer)

Dergi:

Unika Sağlık Bilimleri Dergisi Vol.4 Issue 1, pp.652-660

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001315801

pISSN:

2757-6817

Hypertension

Insulin Resistance

Triglyceride/Glucose IndexHipertansiyon

İnsülin Direnci

Trigliserit/Glukoz İndeksi

Sayı

Makale detayları

The Role of Triglyceride/Glucose Index in Determining Insulin Resistance in Patients Diagnosed with Hypertension

Yazarlar: Muhammet Yıldız | Habibe İnci | Burcu Korkut | Pınar Kalem | Aysegul Ertınmaz Ozkan | Didem Adahan

Yayıncı: Karabuk University

Ana Başlıklar: Halk Sağlığı (Diğer)

Dergi: Unika Sağlık Bilimleri Dergisi Vol.4 Issue 1, pp.652-660

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001315801

pISSN: 2757-6817

Hypertension

Insulin Resistance

Triglyceride/Glucose IndexHipertansiyon

İnsülin Direnci

Trigliserit/Glukoz İndeksi

Sayı

Yazarlar:

Muhammet Yıldız | Habibe İnci | Burcu Korkut | Pınar Kalem | Aysegul Ertınmaz Ozkan | Didem Adahan

Yayıncı:

Karabuk University

Ana Başlıklar:

Halk Sağlığı (Diğer)

Dergi:

Unika Sağlık Bilimleri Dergisi Vol.4 Issue 1, pp.652-660

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001315801

pISSN:

2757-6817