Investigation of Pathergy In Patients With Fibromyalgia

Pelin OKTAYOĞLU; Mehtap BOZKURT; Mehmet ÇAĞLAYAN; Sabahattin VERİM; Kemal NAS

Makale detayları

Investigation of Pathergy In Patients With Fibromyalgia

Yazarlar:

Pelin OKTAYOĞLU | Mehtap BOZKURT | Mehmet ÇAĞLAYAN | Sabahattin VERİM | Kemal NAS

Yayıncı:

Hatay Mustafa Kemal University

Dergi:

The Medical Journal of Mustafa Kemal University 2015 Vol.6 Issue 21

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000599128

Sıklık:

Üç Yıllık

eISSN:

2149-3103

Özet:

 


Aim: Recent studies showed increased axon reflex flare reaction to mechanical and chemical stimuli associated with neurogenic inflammation in patients with fibromyalgia (FM). Pathergy test is identified as a non-specific hypersensitivity reaction to minimal trauma. The purpose of this study was to investigate whether patients with FM had a positive pathergy test or not.

Methods: Forty-six patients who met the 1990 American College of Rheumatology (ACR) criteria for the classification of FM and fifty-one healthy control subjects (HCs) were included in this study. Twenty-eight patients with Behcet’s disease were included as disease control for Pathergy test. The Fibromyalgia Impact Questionnaire (FIQ) was used for assessment of functional status in patients with FM. The Nottingham Health Profile was used for assessment of quality of life in all subjects.

Results: There was no significant difference in demographic characteristics between the three groups (p > 0.05). NHP-pain, NHP-physical mobility, NHP-energy, NHP-emotional reaction, NHP-sleep and NHP-total scores were significantly higher in patients with FM compared to HCs (p < 0.001). Neither patients with FM nor HCs had a positive pathergy test.

Conclusion: There are some pathophysiological changes in the skin biopsies of patients with FM; however, these changes are not accompanied by a positive pathergy test.

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Amaç: Son çalışmalar fibromiyalji (FM) hastalarında mekanik ve kimyasal uyarılara bağlı olarak oluşan nörojenik inflamasyonla beraber artmış aksonal refleks varlığını ortaya koymuştur. Paterji testi derinin minimal bir travmaya karşı gösterdiği nonspesifik hipersensitivite reaksiyonu olarak tanımlanmaktadır. Bu çalışmada amaç, FM’li hastalarda Paterji testinin pozitif olup olmadığının araştırılmasıdır.

Makale detayları

Investigation of Pathergy In Patients With Fibromyalgia

Yazarlar: Pelin OKTAYOĞLU | Mehtap BOZKURT | Mehmet ÇAĞLAYAN | Sabahattin VERİM | Kemal NAS

Yayıncı: Hatay Mustafa Kemal University

Dergi: The Medical Journal of Mustafa Kemal University 2015 Vol.6 Issue 21

Belge Tipi: Makale

Yayın Tarihi: 3/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000599128

Sıklık: Üç Yıllık

eISSN: 2149-3103

Sayı

Yazarlar:

Pelin OKTAYOĞLU | Mehtap BOZKURT | Mehmet ÇAĞLAYAN | Sabahattin VERİM | Kemal NAS

Yayıncı:

Hatay Mustafa Kemal University

Dergi:

The Medical Journal of Mustafa Kemal University 2015 Vol.6 Issue 21

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000599128

Sıklık:

Üç Yıllık

eISSN:

2149-3103