Cyclooxygenase-2 (COX-2) gene polymorphism in patients withdifferentiated thyroid carcinomas in the Turkish population

Bekir UÇAN; Mustafa ÖZBEK; Mustafa ŞAHİN; Muhammed KIZILGÜL; Erman ÇAKAL

Makale detayları

Cyclooxygenase-2 (COX-2) gene polymorphism in patients withdifferentiated thyroid carcinomas in the Turkish population

Yazarlar:

Bekir UÇAN | Mustafa ÖZBEK | Mustafa ŞAHİN | Muhammed KIZILGÜL | Erman ÇAKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 6, pp.1848-1853

Belge Tipi:

Makale

Yayın Tarihi:

11/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751022

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The most common thyroid malignancies are papillary and follicular thyroid carcinomas. They account for approximately 85%-90% of all thyroid cancers. Recent studies have reported the relevance of cyclooxygenase-2 (COX-2) gene polymorphism in human carcinogenesis. The aim of this study was to investigate the relationship between thyroid carcinoma and COX-2 gene polymorphism in the Turkish population.Materials and methods: We included a total of 96 differentiated thyroid cancer patients (mean age: 46.9 ± 10.3 years; 14 males, 82 females) and 83 healthy control subjects (mean age: 46.0 ± 10.6 years; 39 males, 44 females). The frequency of -765G>C, -8473T>C, and 1195A>G gene polymorphisms in the COX-2 promoter region was investigated in thyroid cancer patients and the control group using the high-resolution melting method. Results: COX-2-765G>C and COX-2-1195A>G gene polymorphisms were similar between thyroid cancer patients and the control group. There was a statistically significant difference between COX-2-8473T>C gene polymorphism in the thyroid cancer group and the control group (P = 0.012).Conclusion: The single nucleotide gene polymorphism COX-2-8473T>C might contribute to genetic susceptibility to differentiated thyroid cancer in the Turkish population.

Makale detayları

Cyclooxygenase-2 (COX-2) gene polymorphism in patients withdifferentiated thyroid carcinomas in the Turkish population

Yazarlar: Bekir UÇAN | Mustafa ÖZBEK | Mustafa ŞAHİN | Muhammed KIZILGÜL | Erman ÇAKAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 6, pp.1848-1853

Belge Tipi: Makale

Yayın Tarihi: 11/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751022

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Bekir UÇAN | Mustafa ÖZBEK | Mustafa ŞAHİN | Muhammed KIZILGÜL | Erman ÇAKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 6, pp.1848-1853

Belge Tipi:

Makale

Yayın Tarihi:

11/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751022

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144