Chemical profiling and cytotoxic activity of aqueous extract of Veronica peduncularis M.Bieb.: A chemotaxonomical approach

Zeynep DOĞAN; Yasin GENÇ; Şebnem HARPUT; Asuman KARADENİZ PEKGÖZ; İclal SARAÇOĞLU

Makale detayları

Chemical profiling and cytotoxic activity of aqueous extract of Veronica peduncularis M.Bieb.: A chemotaxonomical approach

Yazarlar:

Zeynep DOĞAN | Yasin GENÇ | Şebnem HARPUT | Asuman KARADENİZ PEKGÖZ | İclal SARAÇOĞLU

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

İstanbul Journal of Pharmacy 2021 Vol.51 Issue 3, pp.372-377

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000512807

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 

Background and Aims: Genus Veronica (Plantaginaceae) is represented by 79 species in Turkish flora, 26 of which are endemic. Veronica species have a variety of uses including diuretic, anticancer, and rheumatic pains, wounds, and respiratory problems. According to phytochemical studies, Veronica species contain predominantly iridoid glucosides with some phenylethanoid and flavonoid glycosides. Methods: The aqueous extract of Veronica peduncularis M.Bieb. was tested for its cytotoxic activity on human rhabdomyosarcoma (RD) and human epidermoid carcinoma (HEp-2) cell lines using the MTT method. Chemical profile of the extract was determined by HPLC-DAD, and isolation studies were conducted. Results: The extract was found to show concentration-dependent cytotoxicity against tested cell lines. In addition, a comparison of the iridoid fraction of Veronica peduncularis with previously isolated iridoid glucosides on the HPLC-DAD system, showed the presence of aucubin, amphicoside, veratroyl catalpol, and veronicoside in this fraction. On the other hand, isolation and structure elucidation of plantamajoside and 4'-O-methylisoscutellarein-7-O-2''-O-(6'''-O-acetyl-ß-D-allopyranosyl)- ß-D-glucopyranoside from the phenolic fractions were performed by serial chromatographic and spectroscopic methods. Conclusion: To the best of our knowledge, this is the first cytotoxic activity and phytochemical study on the titled plant. The presence of iridoid glucosides and 8-hydroxyflavone glycosides is important for the chemotaxonomy of the genus Veronica.

Makale detayları

Chemical profiling and cytotoxic activity of aqueous extract of Veronica peduncularis M.Bieb.: A chemotaxonomical approach

Yazarlar: Zeynep DOĞAN | Yasin GENÇ | Şebnem HARPUT | Asuman KARADENİZ PEKGÖZ | İclal SARAÇOĞLU

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: İstanbul Journal of Pharmacy 2021 Vol.51 Issue 3, pp.372-377

Belge Tipi: Makale

Yayın Tarihi: 12/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000512807

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Zeynep DOĞAN | Yasin GENÇ | Şebnem HARPUT | Asuman KARADENİZ PEKGÖZ | İclal SARAÇOĞLU

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

İstanbul Journal of Pharmacy 2021 Vol.51 Issue 3, pp.372-377

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000512807

Sıklık:

Aylık

eISSN:

2587-2087