The Contribution of Contrast Enhanced CT to FDG PET on Characterization of Liver Lesions and It’s Quantitative Effects

Mutlay Keskin; Şeyda Türkölmez; Elif Özdemir; Nilüfer Yıldırım; Zuhal Kandemir

Makale detayları

The Contribution of Contrast Enhanced CT to FDG PET on Characterization of Liver Lesions and It’s Quantitative Effects

Yazarlar:

Mutlay Keskin | Şeyda Türkölmez | Elif Özdemir | Nilüfer Yıldırım | Zuhal Kandemir

Yayıncı:

Harran University

Ana Başlıklar:

Nükleer Tıp

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.548-554

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298527

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: The goals of this study was to evaluate the diagnostic capability of enhancedunenhanced 18F-FDG-PETCT scans for identifying primary-secondary liver malignancies in terms of size and localization, to decide the quantitative impact of contrast agent on the SUVmax values of liver lesions and normal liver tissue, and to assess the impact in SUVmax metrics following contrast substance administration. Materials and Methods: This was a prospective research that included patients with suspicious primary and secondary hepatic cancers. Patients had non-enhanced  enhanced regional PETCT examinations. The dimen-sion, position, densities HU, visually assessment outcome, and SUVmax values for all pathological lesions were recorded, as well as the HU and SUVmax data of normal hepatic tissue. Results: There were 97 liver lesions in total. Visually assessment outcome of lesions, the introduction of a contrast substance considerably enhanced the HU and SUVmax measurements for normal hepatic tissue. The HU measurements for lesions bigger than 1cm increased statistically significantly, as did the SUVmax levels of centralized lesions bigger than 1cm. The attenuation adjustment procedures, resulted in an average inaccuracy in computed SUVmax values at the ratio of 5 for normal liver tissue and 6 for all hepatic pathologies follow-ing the contrast substance delivery. Conclusions: The inclusion of contrast substance increases the identification, localization, and characterization of the liver lesions with PETCT substantially.

 Background: The goals of this study was to evaluate the diagnostic capability of enhancedunenhanced 18F-FDG-PETCT scans for identifying primary-secondary liver malignancies in terms of size and localization, to decide the quantitative impact of contrast agent on the SUVmax values of liver lesions and normal liver tissue, and to assess the impact in SUVmax metrics following contrast substance administration. Materials and Methods: This was a prospective research that included patients with suspicious primary and secondary hepatic cancers. Patients had non-enhanced  enhanced regional PETCT examinations. The dimen-sion, position, densities HU, visually assessment outcome, and SUVmax values for all pathological lesions were recorded, as well as the HU and SUVmax data of normal hepatic tissue. Results: There were 97 liver lesions in total. Visually assessment outcome of lesions, the introduction of a contrast substance considerably enhanced the HU and SUVmax measurements for normal hepatic tissue. The HU measurements for lesions bigger than 1cm increased statistically significantly, as did the SUVmax levels of centralized lesions bigger than 1cm. The attenuation adjustment procedures, resulted in an average inaccuracy in computed SUVmax values at the ratio of 5 for normal liver tissue and 6 for all hepatic pathologies follow-ing the contrast substance delivery. Conclusions: The inclusion of contrast substance increases the identification, localization, and characterization of the liver lesions with PETCT substantially.

 Background: The goals of this study was to evaluate the diagnostic capability of enhancedunenhanced 18F-FDG-PETCT scans for identifying primary-secondary liver malignancies in terms of size and localization, to decide the quantitative impact of contrast agent on the SUVmax values of liver lesions and normal liver tissue, and to assess the impact in SUVmax metrics following contrast substance administration. Materials and Methods: This was a prospective research that included patients with suspicious primary and secondary hepatic cancers. Patients had non-enhanced  enhanced regional PETCT examinations. The dimen-sion, position, densities HU, visually assessment outcome, and SUVmax values for all pathological lesions were recorded, as well as the HU and SUVmax data of normal hepatic tissue. Results: There were 97 liver lesions in total. Visually assessment outcome of lesions, the introduction of a contrast substance considerably enhanced the HU and SUVmax measurements for normal hepatic tissue. The HU measurements for lesions bigger than 1cm increased statistically significantly, as did the SUVmax levels of centralized lesions bigger than 1cm. The attenuation adjustment procedures, resulted in an average inaccuracy in computed SUVmax values at the ratio of 5 for normal liver tissue and 6 for all hepatic pathologies follow-ing the contrast substance delivery. Conclusions: The inclusion of contrast substance increases the identification, localization, and characterization of the liver lesions with PETCT substantially.

 Amaç: Çalışmadaki amaçlarımız, primer-sekonder karaciğer malignitelerinin boyut, lokalizasyon açısından saptanması için kontrastlıkontrastsız 18F-FDG-PETBT taramalarının tanısal etkinliğini karşılaştırmak, kontrast maddenin karaciğer lezyonlarının ve normal karaciğer dokusunun SUVmaks değerlerindeki kantitatif etkilerini araştırmak, kontrast madde uygulamasından sonra SUVmaks ölçümlerindeki hata düzeyini belirlemekti. Materyal ve Metod: Bu çalışma, primer-sekonder karaciğer malignitesi şüphesi olan bireyleri içeren prospektif çalışmadır. Hastalara bölgesel kontrastsız ve kontrastlı PETBT taramaları yapılmıştır. Malign kabul edilen lezyonların boyutu, lokalizasyonu, dansitesi, görsel derecelendirme skoru, SUVmaks değerleri ile normal karaciğer dokusunun HU, SUVmaks değerleri kaydedilmiştir. Bulgular: Toplam 97 karaciğer lezyonu tespit edildi. Lezyonların görsel derecelendirme skorları, normal karaciğer dokusu için HU ve SUVmaks değerleri kontrast madde verilmesiyle anlamlı olarak arttı. 1cmden büyük lezyonların HU değerlerinde ve 1cmden büyük santral yerleşimli lezyonların SUVmaks değerlerinde istatistiksel anlamlı artış vardı. Atenüasyon düzeltme algoritmaları ile kontrast madde uygulamasından sonra hesaplanan SUVmaks değerlerinde normal karaciğer dokusu için ortalama 5 ve karaciğer lezyonları için 6 hatalı artış vardı. Sonuç: Kontrast madde kullanımı, PETBT ile hepatik lezyonların saptanmasını, lokalizasyonunu ve karakterizasyonunu önemli ölçüde iyileştirmektedir.

Makale detayları

The Contribution of Contrast Enhanced CT to FDG PET on Characterization of Liver Lesions and It’s Quantitative Effects

Yazarlar:

Mutlay Keskin | Şeyda Türkölmez | Elif Özdemir | Nilüfer Yıldırım | Zuhal Kandemir

Yayıncı:

Harran University

Ana Başlıklar:

Nükleer Tıp

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.548-554

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298527

pISSN:

1304-9623

Contrast material

PET/CT

liver lesionKontrast madde

PET/BT

karaciğer lezyonu

Sayı

Makale detayları

The Contribution of Contrast Enhanced CT to FDG PET on Characterization of Liver Lesions and It’s Quantitative Effects

Yazarlar: Mutlay Keskin | Şeyda Türkölmez | Elif Özdemir | Nilüfer Yıldırım | Zuhal Kandemir

Yayıncı: Harran University

Ana Başlıklar: Nükleer Tıp

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.548-554

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001298527

pISSN: 1304-9623

Contrast material

PET/CT

liver lesionKontrast madde

PET/BT

karaciğer lezyonu

Sayı

Yazarlar:

Mutlay Keskin | Şeyda Türkölmez | Elif Özdemir | Nilüfer Yıldırım | Zuhal Kandemir

Yayıncı:

Harran University

Ana Başlıklar:

Nükleer Tıp

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.20 Issue 3, pp.548-554

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298527

pISSN:

1304-9623