The Effect of Paraquat on the Activity of Some Enzymes in Different Tissues of Mice (Mus musculus - Swiss albino)

Egemen DERE

Makale detayları

The Effect of Paraquat on the Activity of Some Enzymes in Different Tissues of Mice (Mus musculus - Swiss albino)

Yazarlar:

Egemen DERE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2001 Vol.25 Issue 3, pp.323-332

Belge Tipi:

Makale

Yayın Tarihi:

2/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000813827

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

The effects of the LD30  (20 mg.kg-1) dose of paraquat, a herbicide, were investigated on creatine kinase (CK), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) activities in the liver, kidney and lung of mice after 2, 4, 8, 16, 32, 64 and 72 hours. After paraquat was given  intraperitoneally to Mus musculus Swiss albino mice, the control groups were injected with physiological saline. The results were evaluated using the autoanalyzer as U/L. Even though significant increases in the liver tissue LDH and GGT, kidney tissue CK and lung tissue CK and LDH activities were noted when compared to those of the control group  (P0.05).  Although there were significant increases observed in GPT enzyme activities in the liver and kidney tissue at the beginning of the experiment, these activities were found to be at nearly the same level as those of  the control group. Liver tissue GOT activity  was lower in comparison with the control group at first but it was found to be statistically insignificant at 8 hours and during the subsequent experiment time periods. A decrease was observed in the CK activity in the liver but a significant increase and then a decrease was observed in the LDH activity in  the liver.  Consequently, it was found that paraquat caused some changes (increases then decreases) in CK, GOT, GPT, LDH and GGT enzyme activity in different tissues of mice. The causes of the increases and decreases in enzyme activities are discussed.

 

The effects of the LD30  (20 mg.kg-1) dose of paraquat, a herbicide, were investigated on creatine kinase (CK), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) activities in the liver, kidney and lung of mice after 2, 4, 8, 16, 32, 64 and 72 hours. After paraquat was given  intraperitoneally to Mus musculus Swiss albino mice, the control groups were injected with physiological saline. The results were evaluated using the autoanalyzer as U/L. Even though significant increases in the liver tissue LDH and GGT, kidney tissue CK and lung tissue CK and LDH activities were noted when compared to those of the control group  (P0.05).  Although there were significant increases observed in GPT enzyme activities in the liver and kidney tissue at the beginning of the experiment, these activities were found to be at nearly the same level as those of  the control group. Liver tissue GOT activity  was lower in comparison with the control group at first but it was found to be statistically insignificant at 8 hours and during the subsequent experiment time periods. A decrease was observed in the CK activity in the liver but a significant increase and then a decrease was observed in the LDH activity in  the liver.  Consequently, it was found that paraquat caused some changes (increases then decreases) in CK, GOT, GPT, LDH and GGT enzyme activity in different tissues of mice. The causes of the increases and decreases in enzyme activities are discussed.

Makale detayları

The Effect of Paraquat on the Activity of Some Enzymes in Different Tissues of Mice (Mus musculus - Swiss albino)

Yazarlar:

Egemen DERE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2001 Vol.25 Issue 3, pp.323-332

Belge Tipi:

Makale

Yayın Tarihi:

2/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000813827

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Paraquat

liver

kidney

lung

enzymes

Sayı

Makale detayları

The Effect of Paraquat on the Activity of Some Enzymes in Different Tissues of Mice (Mus musculus - Swiss albino)

Yazarlar: Egemen DERE

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2001 Vol.25 Issue 3, pp.323-332

Belge Tipi: Makale

Yayın Tarihi: 2/2001

Belge Dili: Türkçe

Document ID (Org No.): 2000813827

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Paraquat

liver

kidney

lung

enzymes

Sayı

Yazarlar:

Egemen DERE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2001 Vol.25 Issue 3, pp.323-332

Belge Tipi:

Makale

Yayın Tarihi:

2/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000813827

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152