Study of Elements, Antioxidants and Lipid Peroxidation in Hemodialysis Patients

Esma MENEVŞE; Abdullah SİVRİKAYA; Emrah KARAGÖZOĞLU; Ali Muhtar TİFTİK; Süleyman TÜRK

Makale detayları

Study of Elements, Antioxidants and Lipid Peroxidation in Hemodialysis Patients

Yazarlar:

Esma MENEVŞE | Abdullah SİVRİKAYA | Emrah KARAGÖZOĞLU | Ali Muhtar TİFTİK | Süleyman TÜRK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2006 Vol.36 Issue 5, pp.279-284

Belge Tipi:

Makale

Yayın Tarihi:

4/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000756142

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background: During hemodialysis, most of the elements must be kept in a rather narrow physiological range, otherwise life-threatening events may occur. Furthermore, lipid peroxidation in patients may be partly due to the trace element disturbances. It has been mentioned that there are relations between deficiency in trace elements and antioxidant levels. The present study aimed to determine whether there were differences between hemodialysis patients and a healthy group according to selenium, aluminium, malondialdehyde (MDA), reduced form of glutathione (GSH) and superoxide dismutase (SOD) levels.  Methods: The study included 47 hemodialysis patients (hemodialysis group). Blood samples were taken before (pre-hemodialysis) and after (post-hemodialysis) hemodialysis session. The control group included 23 healthy volunteers.   Results: The aluminium, MDA, and SOD levels were lower and reduced form of GSH levels were higher in the control group when compared with the pre-hemodialysis group. MDA and SOD levels were higher in the post-hemodialysis group than in the control group. GSH levels were lower and aluminium levels higher in the pre- versus the post-hemodialysis group.   Conclusions: In order to evaluate the data of antioxidant and oxidant levels, hemodialysis patients are subjected to oxidative stress. Moreover, the study shows that analyzing levels of aluminium may be useful in hemodialysis patients in evaluating elements status.

 

Background: During hemodialysis, most of the elements must be kept in a rather narrow physiological range, otherwise life-threatening events may occur. Furthermore, lipid peroxidation in patients may be partly due to the trace element disturbances. It has been mentioned that there are relations between deficiency in trace elements and antioxidant levels. The present study aimed to determine whether there were differences between hemodialysis patients and a healthy group according to selenium, aluminium, malondialdehyde (MDA), reduced form of glutathione (GSH) and superoxide dismutase (SOD) levels.  Methods: The study included 47 hemodialysis patients (hemodialysis group). Blood samples were taken before (pre-hemodialysis) and after (post-hemodialysis) hemodialysis session. The control group included 23 healthy volunteers.   Results: The aluminium, MDA, and SOD levels were lower and reduced form of GSH levels were higher in the control group when compared with the pre-hemodialysis group. MDA and SOD levels were higher in the post-hemodialysis group than in the control group. GSH levels were lower and aluminium levels higher in the pre- versus the post-hemodialysis group.   Conclusions: In order to evaluate the data of antioxidant and oxidant levels, hemodialysis patients are subjected to oxidative stress. Moreover, the study shows that analyzing levels of aluminium may be useful in hemodialysis patients in evaluating elements status.

Makale detayları

Study of Elements, Antioxidants and Lipid Peroxidation in Hemodialysis Patients

Yazarlar:

Esma MENEVŞE | Abdullah SİVRİKAYA | Emrah KARAGÖZOĞLU | Ali Muhtar TİFTİK | Süleyman TÜRK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2006 Vol.36 Issue 5, pp.279-284

Belge Tipi:

Makale

Yayın Tarihi:

4/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000756142

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Hemodialysis

antioxidants

oxidants

selenium

aluminium

Sayı

Makale detayları

Study of Elements, Antioxidants and Lipid Peroxidation in Hemodialysis Patients

Yazarlar: Esma MENEVŞE | Abdullah SİVRİKAYA | Emrah KARAGÖZOĞLU | Ali Muhtar TİFTİK | Süleyman TÜRK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2006 Vol.36 Issue 5, pp.279-284

Belge Tipi: Makale

Yayın Tarihi: 4/2006

Belge Dili: Türkçe

Document ID (Org No.): 2000756142

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Hemodialysis

antioxidants

oxidants

selenium

aluminium

Sayı

Yazarlar:

Esma MENEVŞE | Abdullah SİVRİKAYA | Emrah KARAGÖZOĞLU | Ali Muhtar TİFTİK | Süleyman TÜRK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2006 Vol.36 Issue 5, pp.279-284

Belge Tipi:

Makale

Yayın Tarihi:

4/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000756142

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144