Effect of anticoagulation on infarct volume and NIHSS score in patients with atrial fibrillation and ischaemic stroke

Gökhan Aydoğan; Alper Eren

Makale detayları

Effect of anticoagulation on infarct volume and NIHSS score in patients with atrial fibrillation and ischaemic stroke

Yazarlar:

Gökhan Aydoğan | Alper Eren

Yayıncı:

Pamukkale University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.315-323

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001300673

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: The aim of this study was to evaluate the use of oral anticoagulation OAC in patients with cardioembolic stroke due to non-valvular atrial fibrillation NVAF. The NIHSS National Institute of Healt Stroke Scale score calculated by a neurologist at initial presentation and infarct volume measured semi-automatically in cm3 by Magnetic Resonance Imaging MRI. Materials and methods: A total of 101 NVAF patients with acute ischaemic stroke were included in this retrospective study. Patients were divided into 4 groups according to OAC drug use: Non-OAC users group 1, subtherapeutic dose warfarin users under 70 years of age: INR2.0; over 70 years of age: INR1.6 group 2, therapeutic dose warfarin users under 70 years of age: INR2.0; over 70 years of age: INR1.6 group 3 and therapeutic dose Non-vitamin K oral anticoagulant NOAC users group 4. Results: Infarct volume was calculated as 22.20 cm³ median 0.4-235 cm³ lowest-highest for group 1; 12.95 cm³ 1.3-129 cm³ for group 2; 2.25 cm³ 0.3-89 cm³ for group 3 and 4.40 cm³ 0.2-293 cm³ for group 4 and the difference was statistically significant p0.039. The calculated NIHSS score was 9 4-23 for the group 1, 8.5 3-18 for the group 2, 6.5 2-20 for the group 3, 5 1-22 for the group 4 and the effect of anticoagulation use on NIHSS score was statistically significant p0.029. Conclusion: Anticoagulant treatment holds importance in the primary and secondary prevention of stroke and in enhancing the NIHSS score and infarct volumes among stroke patients, as evidenced in the current study.

 Purpose: The aim of this study was to evaluate the use of oral anticoagulation OAC in patients with cardioembolic stroke due to non-valvular atrial fibrillation NVAF. The NIHSS National Institute of Healt Stroke Scale score calculated by a neurologist at initial presentation and infarct volume measured semi-automatically in cm3 by Magnetic Resonance Imaging MRI. Materials and methods: A total of 101 NVAF patients with acute ischaemic stroke were included in this retrospective study. Patients were divided into 4 groups according to OAC drug use: Non-OAC users group 1, subtherapeutic dose warfarin users under 70 years of age: INR2.0; over 70 years of age: INR1.6 group 2, therapeutic dose warfarin users under 70 years of age: INR2.0; over 70 years of age: INR1.6 group 3 and therapeutic dose Non-vitamin K oral anticoagulant NOAC users group 4. Results: Infarct volume was calculated as 22.20 cm³ median 0.4-235 cm³ lowest-highest for group 1; 12.95 cm³ 1.3-129 cm³ for group 2; 2.25 cm³ 0.3-89 cm³ for group 3 and 4.40 cm³ 0.2-293 cm³ for group 4 and the difference was statistically significant p0.039. The calculated NIHSS score was 9 4-23 for the group 1, 8.5 3-18 for the group 2, 6.5 2-20 for the group 3, 5 1-22 for the group 4 and the effect of anticoagulation use on NIHSS score was statistically significant p0.029. Conclusion: Anticoagulant treatment holds importance in the primary and secondary prevention of stroke and in enhancing the NIHSS score and infarct volumes among stroke patients, as evidenced in the current study.

 Purpose: The aim of this study was to evaluate the use of oral anticoagulation OAC in patients with cardioembolic stroke due to non-valvular atrial fibrillation NVAF. The NIHSS National Institute of Healt Stroke Scale score calculated by a neurologist at initial presentation and infarct volume measured semi-automatically in cm3 by Magnetic Resonance Imaging MRI. Materials and methods: A total of 101 NVAF patients with acute ischaemic stroke were included in this retrospective study. Patients were divided into 4 groups according to OAC drug use: Non-OAC users group 1, subtherapeutic dose warfarin users under 70 years of age: INR2.0; over 70 years of age: INR1.6 group 2, therapeutic dose warfarin users under 70 years of age: INR2.0; over 70 years of age: INR1.6 group 3 and therapeutic dose Non-vitamin K oral anticoagulant NOAC users group 4. Results: Infarct volume was calculated as 22.20 cm³ median 0.4-235 cm³ lowest-highest for group 1; 12.95 cm³ 1.3-129 cm³ for group 2; 2.25 cm³ 0.3-89 cm³ for group 3 and 4.40 cm³ 0.2-293 cm³ for group 4 and the difference was statistically significant p0.039. The calculated NIHSS score was 9 4-23 for the group 1, 8.5 3-18 for the group 2, 6.5 2-20 for the group 3, 5 1-22 for the group 4 and the effect of anticoagulation use on NIHSS score was statistically significant p0.029. Conclusion: Anticoagulant treatment holds importance in the primary and secondary prevention of stroke and in enhancing the NIHSS score and infarct volumes among stroke patients, as evidenced in the current study.

 Amaç: Bu çalışmada non-valvüler atrial fibrilasyona NVAF bağlı kardiyoembolik inme geçiren hastaların oral antikoagülasyon OAK kullanımının, ilk başvuruda nöroloji uzmanı tarafından hesaplanan NIHSS National Institute of Healt Stroke Scale Ulusal sağlık enstitüleri inme ölçeği skoru ve çekilen diffüzyon manyetik rezonans görüntüleme MRG nin cm3 cinsinden semiotomatik olarak ölçülen infarkt volümünün değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: Akut iskemik inme tanısı alan 101 NVAF hastası retrospektif olarak planlanan bu çalışmaya dahil edildi. Hastalar OAK ilaç kullanımına göre 4 gruba ayrıldı: OAK kullanmayanlar grup 1, subterapötik dozda warfarin kullanan 70 yaş altı: INR2,0; 70 yaş üzeri: INR1,6 grup 2, terapötik dozda warfarin kullananlar 70 yaş altı: INR2,0; 70 yaş üzeri; INR1,6 grup 3 ve terapötik dozda Non-vitamin K oral antikoagülan NOAK kullanan grup 4 olmak üzere 4 gruba ayrıldı. Bulgular: İnfarkt volümü 1. grup için 22,20 cm³ medyan: 0,4-235 cm³ en düşük-en yüksek, 2. grup: 12,95 cm³ 1,3-129 cm³, 3. grup: 2,25 cm³ 0,3-89 cm³ ve 4.grup: 4,40 cm³ 0,2-293 cm³ olarak hesaplandı ve aradaki fark istatistiksel olarak anlamlıydı p0,039. Hesaplanan NIHSS skoru 1. grup için 9 4-23, 2. grup: 8,5 3-18, 3. grup: 6,5 2-20, 4.grup 5 1-22 olarak hesaplandı ve antikoagülasyon kullanımının NIHSS skoru üzerine etkisi istatistiksel olarak anlamlı bulundu p0,029. Sonuç: Antikoagülan tedavi, bu çalışmada gösterildiği gibi inme hastalarında NIHSS skorunu ve enfarktüs hacimlerini iyileştirmenin yanı sıra inmenin birincil ve ikincil önlenmesinde önemlidir.

Makale detayları

Effect of anticoagulation on infarct volume and NIHSS score in patients with atrial fibrillation and ischaemic stroke

Yazarlar:

Gökhan Aydoğan | Alper Eren

Yayıncı:

Pamukkale University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.315-323

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001300673

pISSN:

1308-0865

Atrial fibrillation

cardioembolic stroke

ischemic stroke

infarct volume

NIHSS scoreAtrial fibrilasyon

kardioembolik inme

iskemik inme

infarkt volümü

NIHSS skoru

Sayı

Makale detayları

Yazarlar: Gökhan Aydoğan | Alper Eren

Yayıncı: Pamukkale University

Ana Başlıklar: Nöroloji ve Nöromüsküler Hastalıklar

Dergi: Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.315-323

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001300673

pISSN: 1308-0865

Sayı

Yazarlar:

Gökhan Aydoğan | Alper Eren

Yayıncı:

Pamukkale University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Pamukkale Tıp Dergisi Vol.17 Issue 2, pp.315-323

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001300673

pISSN:

1308-0865