Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats

N.A.

Makale detayları

Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Pharmacy and Pharmacy Practice

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1331-1341

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347552

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In this study, we investigated the protective effects of olive cake OC from heart and kidney damage in dexamethasoneinduced hypertensive HT rats. HT rats were divided into two groups fed standard diet supplemented HT-OC or not HT with OC at 7.5 for 28 days. A control group C was submitted to standard diet for the same experimental period. The results showed that serum levels of lactate dehydrogenase LDH, creatine kinase CK, aspartate aminotransferase AST, urea creatinine and uric acid were significantly increased in the HT group compared with the C group. The HT group was associated with increased levels of thiobarbituric acid reactive substances, lipid hydroperoxides and protein carbonyl, while reducing glutathione concentration and glutathione peroxidase, superoxide dismutase and catalase activities in heart and kidney. OC treatment reduced systolic blood pressure, creatinine, urea, uric acid, LDH, CK and AST and increased nitric oxide in serum than the HT group. OC reduced oxidative stress biomarkers and increased antioxidants enzyme activities in heart and kidney than the HT group. In the HT group compared with C, histopathological examination of renal tissues revealed glomerular necrosis, renal tubular distortion, and increased Bowmans space, and that of the heart showed cardiac cells nuclear peripheralization, pyknosis, and congestion of myocardial blood vessels. However, OC treatment attenuated cardiac and renal damage compared with the HT group. Conclusions, in dexamethasone-induced hypertensive rats, OC protects against kidney and heart damage by reducing blood pressure, oxidative stress and improving antioxidant defense. These results could be referred to their flavonoid and polyphenol content.

 In this study, we investigated the protective effects of olive cake OC from heart and kidney damage in dexamethasoneinduced hypertensive HT rats. HT rats were divided into two groups fed standard diet supplemented HT-OC or not HT with OC at 7.5 for 28 days. A control group C was submitted to standard diet for the same experimental period. The results showed that serum levels of lactate dehydrogenase LDH, creatine kinase CK, aspartate aminotransferase AST, urea creatinine and uric acid were significantly increased in the HT group compared with the C group. The HT group was associated with increased levels of thiobarbituric acid reactive substances, lipid hydroperoxides and protein carbonyl, while reducing glutathione concentration and glutathione peroxidase, superoxide dismutase and catalase activities in heart and kidney. OC treatment reduced systolic blood pressure, creatinine, urea, uric acid, LDH, CK and AST and increased nitric oxide in serum than the HT group. OC reduced oxidative stress biomarkers and increased antioxidants enzyme activities in heart and kidney than the HT group. In the HT group compared with C, histopathological examination of renal tissues revealed glomerular necrosis, renal tubular distortion, and increased Bowmans space, and that of the heart showed cardiac cells nuclear peripheralization, pyknosis, and congestion of myocardial blood vessels. However, OC treatment attenuated cardiac and renal damage compared with the HT group. Conclusions, in dexamethasone-induced hypertensive rats, OC protects against kidney and heart damage by reducing blood pressure, oxidative stress and improving antioxidant defense. These results could be referred to their flavonoid and polyphenol content.

 In this study, we investigated the protective effects of olive cake OC from heart and kidney damage in dexamethasoneinduced hypertensive HT rats. HT rats were divided into two groups fed standard diet supplemented HT-OC or not HT with OC at 7.5 for 28 days. A control group C was submitted to standard diet for the same experimental period. The results showed that serum levels of lactate dehydrogenase LDH, creatine kinase CK, aspartate aminotransferase AST, urea creatinine and uric acid were significantly increased in the HT group compared with the C group. The HT group was associated with increased levels of thiobarbituric acid reactive substances, lipid hydroperoxides and protein carbonyl, while reducing glutathione concentration and glutathione peroxidase, superoxide dismutase and catalase activities in heart and kidney. OC treatment reduced systolic blood pressure, creatinine, urea, uric acid, LDH, CK and AST and increased nitric oxide in serum than the HT group. OC reduced oxidative stress biomarkers and increased antioxidants enzyme activities in heart and kidney than the HT group. In the HT group compared with C, histopathological examination of renal tissues revealed glomerular necrosis, renal tubular distortion, and increased Bowmans space, and that of the heart showed cardiac cells nuclear peripheralization, pyknosis, and congestion of myocardial blood vessels. However, OC treatment attenuated cardiac and renal damage compared with the HT group. Conclusions, in dexamethasone-induced hypertensive rats, OC protects against kidney and heart damage by reducing blood pressure, oxidative stress and improving antioxidant defense. These results could be referred to their flavonoid and polyphenol content.

 In this study, we investigated the protective effects of olive cake OC from heart and kidney damage in dexamethasoneinduced hypertensive HT rats. HT rats were divided into two groups fed standard diet supplemented HT-OC or not HT with OC at 7.5 for 28 days. A control group C was submitted to standard diet for the same experimental period. The results showed that serum levels of lactate dehydrogenase LDH, creatine kinase CK, aspartate aminotransferase AST, urea creatinine and uric acid were significantly increased in the HT group compared with the C group. The HT group was associated with increased levels of thiobarbituric acid reactive substances, lipid hydroperoxides and protein carbonyl, while reducing glutathione concentration and glutathione peroxidase, superoxide dismutase and catalase activities in heart and kidney. OC treatment reduced systolic blood pressure, creatinine, urea, uric acid, LDH, CK and AST and increased nitric oxide in serum than the HT group. OC reduced oxidative stress biomarkers and increased antioxidants enzyme activities in heart and kidney than the HT group. In the HT group compared with C, histopathological examination of renal tissues revealed glomerular necrosis, renal tubular distortion, and increased Bowmans space, and that of the heart showed cardiac cells nuclear peripheralization, pyknosis, and congestion of myocardial blood vessels. However, OC treatment attenuated cardiac and renal damage compared with the HT group. Conclusions, in dexamethasone-induced hypertensive rats, OC protects against kidney and heart damage by reducing blood pressure, oxidative stress and improving antioxidant defense. These results could be referred to their flavonoid and polyphenol content.

Makale detayları

Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Pharmacy and Pharmacy Practice

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1331-1341

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347552

pISSN:

2630-6344

Hypertension rat

dexamethasone

olive cake

antioxidant enzymes

oxidative stress

Sayı

Makale detayları

Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Clinical Pharmacy and Pharmacy Practice

Dergi: Journal of Research in Pharmacy Vol.26 Issue 5, pp.1331-1341

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347552

pISSN: 2630-6344

Hypertension rat

dexamethasone

olive cake

antioxidant enzymes

oxidative stress

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Pharmacy and Pharmacy Practice

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1331-1341

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347552

pISSN:

2630-6344