Evaluation of Ultrasonographic Characteristics and Cytopathological Results of Autonomous (Toxic) Thyroid Nodules

Mustafa Çalışkan

Makale detayları

Evaluation of Ultrasonographic Characteristics and Cytopathological Results of Autonomous (Toxic) Thyroid Nodules

Yazarlar:

Mustafa Çalışkan

Yayıncı:

Duzce University

Ana Başlıklar:

Health Services and Systems (Other)

Dergi:

Konuralp Medical Journal Vol.15 Issue 3, pp.390-394

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301716

pISSN:

1309-3878

Anahtar kelimeler:

Özet:

 Objective: Thyroid nodules are clinical conditions frequently encountered in the community and known to be associated with malignancy. In this study, it was aimed to determine the frequency of malignancy in patients diagnosed with autonomous toxic thyroid nodules TTN. In addition, the effectiveness of ultrasonography US findings and fine needle aspiration FNA results in helping the diagnosis of malignancy were investigated. Methods: Autonomous Toxic thyroid nodule was diagnosed by presence of nodule on US in the presence of subclinical or clinical hyperthyroidism, and detection of suppression in other parts of the gland with increased activity in scintigraphy performed with Tc99m pertechnetate. Fine-needle aspiration was performed on patients who were considered suspicious by ultrasonographic findings. The histopathology results of the patients who were found to need surgical resection were recorded. Results: 125 patients with autonomous toxic thyroid nodules were included in the study. Of the patients, 82 65.60 were female and 43 34.40 were male, with a mean age of 63.5511.13 years. Ultrasonography revealed that nodules were less frequently located in the isthmus and left upper pole. The presence of microcalcification was detected in 8 6.4 patients. Histopathologically, the nodules of 2 1.6 patients were found to be malignant. Both patients who were found to be malignant were male and their nodules were seen as hypoechoic on US. Conclusions: Since it has been seen that autonomic toxic thyroid nodules may be related to malignancy, careful evaluation of male patients with a hypoechoic image on US was considered appropriate.

 Objective: Thyroid nodules are clinical conditions frequently encountered in the community and known to be associated with malignancy. In this study, it was aimed to determine the frequency of malignancy in patients diagnosed with autonomous toxic thyroid nodules TTN. In addition, the effectiveness of ultrasonography US findings and fine needle aspiration FNA results in helping the diagnosis of malignancy were investigated. Methods: Autonomous Toxic thyroid nodule was diagnosed by presence of nodule on US in the presence of subclinical or clinical hyperthyroidism, and detection of suppression in other parts of the gland with increased activity in scintigraphy performed with Tc99m pertechnetate. Fine-needle aspiration was performed on patients who were considered suspicious by ultrasonographic findings. The histopathology results of the patients who were found to need surgical resection were recorded. Results: 125 patients with autonomous toxic thyroid nodules were included in the study. Of the patients, 82 65.60 were female and 43 34.40 were male, with a mean age of 63.5511.13 years. Ultrasonography revealed that nodules were less frequently located in the isthmus and left upper pole. The presence of microcalcification was detected in 8 6.4 patients. Histopathologically, the nodules of 2 1.6 patients were found to be malignant. Both patients who were found to be malignant were male and their nodules were seen as hypoechoic on US. Conclusions: Since it has been seen that autonomic toxic thyroid nodules may be related to malignancy, careful evaluation of male patients with a hypoechoic image on US was considered appropriate.

 Objective: Thyroid nodules are clinical conditions frequently encountered in the community and known to be associated with malignancy. In this study, it was aimed to determine the frequency of malignancy in patients diagnosed with autonomous toxic thyroid nodules TTN. In addition, the effectiveness of ultrasonography US findings and fine needle aspiration FNA results in helping the diagnosis of malignancy were investigated. Methods: Autonomous Toxic thyroid nodule was diagnosed by presence of nodule on US in the presence of subclinical or clinical hyperthyroidism, and detection of suppression in other parts of the gland with increased activity in scintigraphy performed with Tc99m pertechnetate. Fine-needle aspiration was performed on patients who were considered suspicious by ultrasonographic findings. The histopathology results of the patients who were found to need surgical resection were recorded. Results: 125 patients with autonomous toxic thyroid nodules were included in the study. Of the patients, 82 65.60 were female and 43 34.40 were male, with a mean age of 63.5511.13 years. Ultrasonography revealed that nodules were less frequently located in the isthmus and left upper pole. The presence of microcalcification was detected in 8 6.4 patients. Histopathologically, the nodules of 2 1.6 patients were found to be malignant. Both patients who were found to be malignant were male and their nodules were seen as hypoechoic on US. Conclusions: Since it has been seen that autonomic toxic thyroid nodules may be related to malignancy, careful evaluation of male patients with a hypoechoic image on US was considered appropriate.

 Amaç: Tiroid nodülleritoplumda sık karşılaşılan ve maligniteyle ilişkili olduğu bilinen klinik durumlardır. Bu çalışmada otonom toksik tiroid nodülleri TTN tanısı konulan hastalardaki malignite sıklığını belirlemek amaçlandı. Ayrıca ultrasonografi US bulguları ve ince iğne aspirasyonu İİA sonuçlarının malignite tanısına yardımcı olmadaki etkinliği araştırıldı. Gereç ve Yöntem: Otonom Toksik tiroid nodülü tanısı, subklinik veya klinik hipertiroidi varlığında USde nodül ve Tc99m perteknetat ile yapılan sintigrafide nodül veya nodüllere uyan alanlarda aktivite tutulumda artış ile birlikte bezin diğer kısımlarında supresyon saptanması ile kondu. Ultrasonografi bulguları ile şüpheli olarak değerlendirilen hastalara ince iğne aspirasyonu yapıldı. Cerrahi rezeksiyon gerekliliği saptanan hastaların histopatoloji sonuçları kaydedildi. Bulgular: Çalışmaya otonom toksik tiroid nodülü saptanan 125 hasta dahil edilmiştir. Hastaların 82si 65,60 kadın, 43ü 34,40 erkek olup yaş ortalamaları 63,5511,13 idi. Ultrasonografide nodüllerin isthmus ve sol üst polde daha az sıklıkla yerleştiği saptanmıştır. İzoekoik nodül görüntüsünün hipoekoik ve karışık eko görüntüden daha az olduğu görülmüştür p0,001. Mikrokalsifikasyon varlığı ise 8 6,4 hastada tespit edilmiştir. Histopatolojik olarak 2 1,6 hastanın nodülü malign olarak tespit edilmiştir. Malign olarak saptanan iki hasta da erkekti ve nodülleri USde hipoekoik olarak görülmüştür. Sonuç: Otonom toksik tiroid nodüllerinin malignite ile ilgili olabileceği görüldüğünden, USde hipoekoik görüntüsü olan erkek hastalarda dikkatli değerlendirme yapılmasının uygun olduğu düşünülmüştür.

Makale detayları

Evaluation of Ultrasonographic Characteristics and Cytopathological Results of Autonomous (Toxic) Thyroid Nodules

Yazarlar:

Mustafa Çalışkan

Yayıncı:

Duzce University

Ana Başlıklar:

Health Services and Systems (Other)

Dergi:

Konuralp Medical Journal Vol.15 Issue 3, pp.390-394

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301716

pISSN:

1309-3878

Toxic Thyroid Nodule

Malignancy

Ultrasonography.Toksik Tiroid Nodulü

Malignite

Ultrasonografi.

Sayı

Makale detayları

Evaluation of Ultrasonographic Characteristics and Cytopathological Results of Autonomous (Toxic) Thyroid Nodules

Yazarlar: Mustafa Çalışkan

Yayıncı: Duzce University

Ana Başlıklar: Health Services and Systems (Other)

Dergi: Konuralp Medical Journal Vol.15 Issue 3, pp.390-394

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001301716

pISSN: 1309-3878

Toxic Thyroid Nodule

Malignancy

Ultrasonography.Toksik Tiroid Nodulü

Malignite

Ultrasonografi.

Sayı

Yazarlar:

Mustafa Çalışkan

Yayıncı:

Duzce University

Ana Başlıklar:

Health Services and Systems (Other)

Dergi:

Konuralp Medical Journal Vol.15 Issue 3, pp.390-394

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001301716

pISSN:

1309-3878