Positive correlation of galanin with insulin resistance and triglyceride levels in obese  children

Sezer ACAR; Ahu PAKETÇİ; Tuncay KÜME; Korcan DEMİR; Özlem Gürsoy ÇALAN; Ece BÖBER; Ayhan ABACI

Makale detayları

Positive correlation of galanin with insulin resistance and triglyceride levels in obese children

Yazarlar:

Sezer ACAR | Ahu PAKETÇİ | Tuncay KÜME | Korcan DEMİR | Özlem Gürsoy ÇALAN | Ece BÖBER | Ayhan ABACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.560-568

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750724

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Galanin is a neuropeptide that is shown to be involved in the regulation of food intake and glucose homeostasis. The  objective of this study was to evaluate the relation of serum galanin levels with anthropometric and metabolic parameters in obese and  healthy children.  Material and methods: The cross-sectional study consisted of 38 obese children (mean age: 11.9 ± 3.0 years) and 30 healthy children  (mean age: 11.4 ± 2.0 years). Clinical and biochemical parameters [glucose, insulin, homeostasis model assessment-insulin resistance  (HOMA-IR), lipids, galanin, and leptin levels] were assessed.  Results: Serum galanin and leptin levels were significantly higher in obese children. In obese children, galanin levels were positively  correlated with fasting glucose (r = 0.398, p = 0.013), insulin (r = 0.383, p = 0.018), HOMA-IR (r = 0.375, p = 0.020), and triglycerides  (r = 0.391, p=0.015). Multivariate backward regression analysis revealed that galanin levels were significantly associated with fasting  glucose, insulin, HOMA-IR, and triglyceride, which explained 42.0% of the variance (r2 = 0.483, P < 0.001).  Conclusions: Serum galanin levels were significantly higher in obese children than healthy controls and positively correlated with  insulin resistance and triglycerides in obese children. This study suggests that galanin is associated with glucose homeostasis and lipid  metabolism in childhood obesity.

Makale detayları

Positive correlation of galanin with insulin resistance and triglyceride levels in obese children

Yazarlar: Sezer ACAR | Ahu PAKETÇİ | Tuncay KÜME | Korcan DEMİR | Özlem Gürsoy ÇALAN | Ece BÖBER | Ayhan ABACI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.560-568

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750724

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Sezer ACAR | Ahu PAKETÇİ | Tuncay KÜME | Korcan DEMİR | Özlem Gürsoy ÇALAN | Ece BÖBER | Ayhan ABACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.560-568

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750724

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144