The Importance of 25 Hydroxyvitamin D Level Monitoring in Children Diagnosed with Juvenile Idiopathic Arthritis

Ülkü Miray Yıldırım; Müferet Ergüven

Makale detayları

The Importance of 25 Hydroxyvitamin D Level Monitoring in Children Diagnosed with Juvenile Idiopathic Arthritis

Yazarlar:

Ülkü Miray Yıldırım | Müferet Ergüven

Yayıncı:

Duzce University

Ana Başlıklar:

Health Services and Systems (Other)

Dergi:

Konuralp Medical Journal Vol.16 Issue 1, pp.83-87

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313161

pISSN:

1309-3878

Anahtar kelimeler:

Özet:

 Objective: In patients with juvenile idiopathic arthritis JIA, bone metabolism may be negatively affected due to both the activity of the disease and the medications used. Our study aimed to investigate the necessity of evaluating 25 hydroxyvitamin D 25 OH Vit D, calcium Ca, phosphorus P, alkaline phosphatase ALP levels and possible related factors in the follow-up of patients diagnosed with JIA. Method: The records of 68 patients with JIA were retrospectively evaluated. Disease subtypes, medications used, and whether they were in remission or active disease were reviewed. Results: 25 OH Vit D levels were low in 14.7 of patients with JIA compared to the control group. 66.6 of the patients with systemic arthritis had high ALP levels. 25 OH Vit D level was low in 16.6 of steroid users, and Vitamin D level was low in 55.5 of the patients in the active disease group. It was determined that patients in the active disease group had the highest ALP and lowest vitamin D levels compared to patients in remission with and without medication. Conclusion: Bone metabolism in patients with JIA is negatively affected. Since vitamin D plays a crucial role in bone metabolism, it was emphasized that vitamin D levels should be evaluated especially during active disease and supplements should be provided for patients with low vitamin D levels.

 Objective: In patients with juvenile idiopathic arthritis JIA, bone metabolism may be negatively affected due to both the activity of the disease and the medications used. Our study aimed to investigate the necessity of evaluating 25 hydroxyvitamin D 25 OH Vit D, calcium Ca, phosphorus P, alkaline phosphatase ALP levels and possible related factors in the follow-up of patients diagnosed with JIA. Method: The records of 68 patients with JIA were retrospectively evaluated. Disease subtypes, medications used, and whether they were in remission or active disease were reviewed. Results: 25 OH Vit D levels were low in 14.7 of patients with JIA compared to the control group. 66.6 of the patients with systemic arthritis had high ALP levels. 25 OH Vit D level was low in 16.6 of steroid users, and Vitamin D level was low in 55.5 of the patients in the active disease group. It was determined that patients in the active disease group had the highest ALP and lowest vitamin D levels compared to patients in remission with and without medication. Conclusion: Bone metabolism in patients with JIA is negatively affected. Since vitamin D plays a crucial role in bone metabolism, it was emphasized that vitamin D levels should be evaluated especially during active disease and supplements should be provided for patients with low vitamin D levels.

 Objective: In patients with juvenile idiopathic arthritis JIA, bone metabolism may be negatively affected due to both the activity of the disease and the medications used. Our study aimed to investigate the necessity of evaluating 25 hydroxyvitamin D 25 OH Vit D, calcium Ca, phosphorus P, alkaline phosphatase ALP levels and possible related factors in the follow-up of patients diagnosed with JIA. Method: The records of 68 patients with JIA were retrospectively evaluated. Disease subtypes, medications used, and whether they were in remission or active disease were reviewed. Results: 25 OH Vit D levels were low in 14.7 of patients with JIA compared to the control group. 66.6 of the patients with systemic arthritis had high ALP levels. 25 OH Vit D level was low in 16.6 of steroid users, and Vitamin D level was low in 55.5 of the patients in the active disease group. It was determined that patients in the active disease group had the highest ALP and lowest vitamin D levels compared to patients in remission with and without medication. Conclusion: Bone metabolism in patients with JIA is negatively affected. Since vitamin D plays a crucial role in bone metabolism, it was emphasized that vitamin D levels should be evaluated especially during active disease and supplements should be provided for patients with low vitamin D levels.

 Amaç: Juvenil idiyopatik artrit JİAli hastalarda gerek hastalığın aktivitesi gerekse kullanılan ilaçlar nedeni ile kemik metabolizması olumsuz etkilenebilir. Çalışmamızda JİA tanılı hastaların takibinde 25 hidroksivitamin D 25 OH Vit D, kalsiyum Ca, fosfor P, alkalen fosfataz ALP düzeyleri ve ilişkili olabilecek faktörlerin değerlendirilmesinin gerekliliğini araştırmak amaçlandı Metod: JİA tanılı 68 hastanın kayıtları retrospektif olarak değerlendirildi. Hastalık alt tipleri, remisyon durumu, kullanılan ilaçlar incelendi. Bulgular: Kontrol grubuna kıyasla JİA hastalarının 14,7sinde vitamin D düzeyinin düşük olduğu bulundu. Sistemik artriti olan hastaların 66,6sında ALP düzeyinin yüksek olduğu saptandı. Steroid kullananların 16,6sında vitamin D düzeyi düşük bulundu. İlaçlı ve ilaçsız remisyondaki hastalarla kontrol grubu arasında biyokimyasal parametreler açısından fark yoktu. Aktif hastalık grubundaki hastaların 55,5inde vitamin D düzeyleri düşük saptandı. Aktif hastalık grubundaki hastaların, ilaçlı ve ilaçsız remisyondaki hastalar ile karşılaştırıldığında, en yüksek ALP ve en düşük vitamin D düzeyine sahip oldukları saptandı. Sonuç: JİAlı hastalarda kemik metabolizması olumsuz etkilenmektedir. D vitamininin kemik metabolizması üzerinde önemli rol oynaması nedeni ile bu hasta grubunda özellikle aktif hastalık sırasında vitamin D düzeylerinin bakılması ve D vitamini düşük saptanan hastalara vitamin D desteği verilmesi gerekliliği vurgulandı.

Makale detayları

The Importance of 25 Hydroxyvitamin D Level Monitoring in Children Diagnosed with Juvenile Idiopathic Arthritis

Yazarlar:

Ülkü Miray Yıldırım | Müferet Ergüven

Yayıncı:

Duzce University

Ana Başlıklar:

Health Services and Systems (Other)

Dergi:

Konuralp Medical Journal Vol.16 Issue 1, pp.83-87

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313161

pISSN:

1309-3878

Juvenile idiopathic arthritis

vitamin D

bone metabolism: Juvenil idiyopatik artrit

D vitamini

kemik metabolizması

Sayı

Makale detayları

The Importance of 25 Hydroxyvitamin D Level Monitoring in Children Diagnosed with Juvenile Idiopathic Arthritis

Yazarlar: Ülkü Miray Yıldırım | Müferet Ergüven

Yayıncı: Duzce University

Ana Başlıklar: Health Services and Systems (Other)

Dergi: Konuralp Medical Journal Vol.16 Issue 1, pp.83-87

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001313161

pISSN: 1309-3878

Juvenile idiopathic arthritis

vitamin D

bone metabolism: Juvenil idiyopatik artrit

D vitamini

kemik metabolizması

Sayı

Yazarlar:

Ülkü Miray Yıldırım | Müferet Ergüven

Yayıncı:

Duzce University

Ana Başlıklar:

Health Services and Systems (Other)

Dergi:

Konuralp Medical Journal Vol.16 Issue 1, pp.83-87

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001313161

pISSN:

1309-3878