SERUM SELENIUM, ZINC, COPPER AND IRON CONCENTRATIONS AND SOME RELATED ANTIOXIDAN TENZYMES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS

A. Koçyiğit; O. Erel; MS. Gürel; S. Avcı; N. Aktepe

Makale detayları

SERUM SELENIUM, ZINC, COPPER AND IRON CONCENTRATIONS AND SOME RELATED ANTIOXIDAN TENZYMES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS

Yazarlar:

A. Koçyiğit | O. Erel | MS. Gürel | S. Avcı | N. Aktepe

Yayıncı:

Marmara University

Ana Başlıklar:

Hastalıklar

Dergi:

Marmara Medical Journal 1998 Vol.11 Issue 2, pp.77-82

Belge Tipi:

Makale

Yayın Tarihi:

2/1998

Belge Dili:

İngilizce

Document ID (Org No.):

2000546956

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

Özet:

 


Objective: This study has been carried out to measure the alterations of some trace element concentrations, their related antioxidant enzyme activities, and carrier proteins in patients with cutaneous leishmaniasis (CL).

Methods: Serum selenium, copper and zinc concentrations were determined by Atomic Absorption Spectrometer. Erythrocyte Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities and ceruloplasmin (Cp) levels were measured with enzymatic colorimetric methods and transferrin (Tf) levels were measured with turbidimetric method.

Results: Erythrocyte Cu-Zn SOD activities, serum copper concentrations and Cp levels were found to be significantly higher in patients group, than those of controls. However, GSH-Px and CAT activities, and selenium, zinc, iron and Tf levels were lower in patients according to the control subjects. There were positive important correlations between Cu-Zn SOD and Cp, Cu-Zn SOD and copper, Cp and copper, GSH-Px and selenium, and iron and CAT in patients group.

Conclusion: Our results showed that serum

essential trace elements selenium, zinc, copper and iron concentrations and their related enzymes Cu-Zn SOD, GSH-Px and CAT activities change in CL patients. The changes may be a part of defense strategies of organism and are induced by the hormone-like substances.

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Makale detayları

SERUM SELENIUM, ZINC, COPPER AND IRON CONCENTRATIONS AND SOME RELATED ANTIOXIDAN TENZYMES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS

Yazarlar: A. Koçyiğit | O. Erel | MS. Gürel | S. Avcı | N. Aktepe

Yayıncı: Marmara University

Ana Başlıklar: Hastalıklar

Dergi: Marmara Medical Journal 1998 Vol.11 Issue 2, pp.77-82

Belge Tipi: Makale

Yayın Tarihi: 2/1998

Belge Dili: İngilizce

Document ID (Org No.): 2000546956

Sıklık: Aylık

eISSN: 1309-9469

pISSN: 1019-1941

Sayı

Yazarlar:

A. Koçyiğit | O. Erel | MS. Gürel | S. Avcı | N. Aktepe

Yayıncı:

Marmara University

Ana Başlıklar:

Hastalıklar

Dergi:

Marmara Medical Journal 1998 Vol.11 Issue 2, pp.77-82

Belge Tipi:

Makale

Yayın Tarihi:

2/1998

Belge Dili:

İngilizce

Document ID (Org No.):

2000546956

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941