Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre

Mehmet Murat Günay; Mehmet Furkan Doğan; İlker Akyildiz; Sibel Alicura Tokgöz; Gökhan Toptaş; Muharrem Dağlı; Mustafa Tarık Alay

Makale detayları

Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre

Yazarlar:

Mehmet Murat Günay | Mehmet Furkan Doğan | İlker Akyildiz | Sibel Alicura Tokgöz | Gökhan Toptaş | Muharrem Dağlı | Mustafa Tarık Alay

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 1, pp.1-9

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344887

pISSN:

2602-4837

Anahtar kelimeler:

Özet:

 Objective: This study assesses the demographic and clinical characteristics, diagnostic and treatment methods, and long-term outcomes of patients diagnosed with and treated for otogenic skull base osteomyelitis OSBO. Second, we attempted to determine the effect of hyperbaric oxygen treatment HBOT on the treatment of OSBO. Material and Methods: We conducted a retrospective analysis of the medical records of 17 patients hospitalised with an OSBO diagnosis in our clinic from 2017 to 2024. We reviewed the demographic infor mation, symptoms, laboratory results, imaging and treatment methods, length of hospital stay, associated complications, and follow-up periods. Results: Nearly all patients, except one, were elderly males mean age: 68.9 years; range: 5781 years. All patients had type 2 DM, with 88.2 n15 having multiple comorbidities, including hypertension and coronary artery disease. The most common symptoms were otalgia, hearing loss, and otorrhea, with cranial nerve CN palsy observed in 70.6 n12. Five patients experienced single CN involvement CN VII in three, CN XII in one, and CN VI in one, while seven had multiple CN palsy. The mean length of hospital stay was 45 days range: 2180 days. In addition to intravenous antibiotic therapy, hyperbaric oxygen therapy HBOT was administered to 52.9 n9. In the HBOT group, no significant reduction was observed in morbidity or length of hospital stay. During the 7-year follow-up period, mortality occurred in 17.6 n3. Conclusion: OSBO should be considered as a differential diagnosis in elderly diabetic patients with persistent otalgia and otorrhea who do not respond to empirical antibiotic therapy. Although our study did not reveal any significant effects of HBOT on OSBO prognosis or length of hospital stay, randomised controlled trials are needed to assess its potential benefits.

 Objective: This study assesses the demographic and clinical characteristics, diagnostic and treatment methods, and long-term outcomes of patients diagnosed with and treated for otogenic skull base osteomyelitis OSBO. Second, we attempted to determine the effect of hyperbaric oxygen treatment HBOT on the treatment of OSBO. Material and Methods: We conducted a retrospective analysis of the medical records of 17 patients hospitalised with an OSBO diagnosis in our clinic from 2017 to 2024. We reviewed the demographic infor mation, symptoms, laboratory results, imaging and treatment methods, length of hospital stay, associated complications, and follow-up periods. Results: Nearly all patients, except one, were elderly males mean age: 68.9 years; range: 5781 years. All patients had type 2 DM, with 88.2 n15 having multiple comorbidities, including hypertension and coronary artery disease. The most common symptoms were otalgia, hearing loss, and otorrhea, with cranial nerve CN palsy observed in 70.6 n12. Five patients experienced single CN involvement CN VII in three, CN XII in one, and CN VI in one, while seven had multiple CN palsy. The mean length of hospital stay was 45 days range: 2180 days. In addition to intravenous antibiotic therapy, hyperbaric oxygen therapy HBOT was administered to 52.9 n9. In the HBOT group, no significant reduction was observed in morbidity or length of hospital stay. During the 7-year follow-up period, mortality occurred in 17.6 n3. Conclusion: OSBO should be considered as a differential diagnosis in elderly diabetic patients with persistent otalgia and otorrhea who do not respond to empirical antibiotic therapy. Although our study did not reveal any significant effects of HBOT on OSBO prognosis or length of hospital stay, randomised controlled trials are needed to assess its potential benefits.

 Objective: This study assesses the demographic and clinical characteristics, diagnostic and treatment methods, and long-term outcomes of patients diagnosed with and treated for otogenic skull base osteomyelitis OSBO. Second, we attempted to determine the effect of hyperbaric oxygen treatment HBOT on the treatment of OSBO. Material and Methods: We conducted a retrospective analysis of the medical records of 17 patients hospitalised with an OSBO diagnosis in our clinic from 2017 to 2024. We reviewed the demographic infor mation, symptoms, laboratory results, imaging and treatment methods, length of hospital stay, associated complications, and follow-up periods. Results: Nearly all patients, except one, were elderly males mean age: 68.9 years; range: 5781 years. All patients had type 2 DM, with 88.2 n15 having multiple comorbidities, including hypertension and coronary artery disease. The most common symptoms were otalgia, hearing loss, and otorrhea, with cranial nerve CN palsy observed in 70.6 n12. Five patients experienced single CN involvement CN VII in three, CN XII in one, and CN VI in one, while seven had multiple CN palsy. The mean length of hospital stay was 45 days range: 2180 days. In addition to intravenous antibiotic therapy, hyperbaric oxygen therapy HBOT was administered to 52.9 n9. In the HBOT group, no significant reduction was observed in morbidity or length of hospital stay. During the 7-year follow-up period, mortality occurred in 17.6 n3. Conclusion: OSBO should be considered as a differential diagnosis in elderly diabetic patients with persistent otalgia and otorrhea who do not respond to empirical antibiotic therapy. Although our study did not reveal any significant effects of HBOT on OSBO prognosis or length of hospital stay, randomised controlled trials are needed to assess its potential benefits.

 Objective: This study assesses the demographic and clinical characteristics, diagnostic and treatment methods, and long-term outcomes of patients diagnosed with and treated for otogenic skull base osteomyelitis OSBO. Second, we attempted to determine the effect of hyperbaric oxygen treatment HBOT on the treatment of OSBO. Material and Methods: We conducted a retrospective analysis of the medical records of 17 patients hospitalised with an OSBO diagnosis in our clinic from 2017 to 2024. We reviewed the demographic infor mation, symptoms, laboratory results, imaging and treatment methods, length of hospital stay, associated complications, and follow-up periods. Results: Nearly all patients, except one, were elderly males mean age: 68.9 years; range: 5781 years. All patients had type 2 DM, with 88.2 n15 having multiple comorbidities, including hypertension and coronary artery disease. The most common symptoms were otalgia, hearing loss, and otorrhea, with cranial nerve CN palsy observed in 70.6 n12. Five patients experienced single CN involvement CN VII in three, CN XII in one, and CN VI in one, while seven had multiple CN palsy. The mean length of hospital stay was 45 days range: 2180 days. In addition to intravenous antibiotic therapy, hyperbaric oxygen therapy HBOT was administered to 52.9 n9. In the HBOT group, no significant reduction was observed in morbidity or length of hospital stay. During the 7-year follow-up period, mortality occurred in 17.6 n3. Conclusion: OSBO should be considered as a differential diagnosis in elderly diabetic patients with persistent otalgia and otorrhea who do not respond to empirical antibiotic therapy. Although our study did not reveal any significant effects of HBOT on OSBO prognosis or length of hospital stay, randomised controlled trials are needed to assess its potential benefits.

Makale detayları

Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre

Yazarlar:

Mehmet Murat Günay | Mehmet Furkan Doğan | İlker Akyildiz | Sibel Alicura Tokgöz | Gökhan Toptaş | Muharrem Dağlı | Mustafa Tarık Alay

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 1, pp.1-9

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344887

pISSN:

2602-4837

Skull base osteomyelitis

temporal bone osteomyelitis

malignant otitis externa

hyperbaric oxygen therapy

cranial nerve palsy

diabetes mellitus

Sayı

Makale detayları

Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre

Yazarlar: Mehmet Murat Günay | Mehmet Furkan Doğan | İlker Akyildiz | Sibel Alicura Tokgöz | Gökhan Toptaş | Muharrem Dağlı | Mustafa Tarık Alay

Yayıncı: Istanbul University

Ana Başlıklar: Otorhinolaryngology

Dergi: The Turkish Journal of Ear Nose and Throat Vol.35 Issue 1, pp.1-9

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344887

pISSN: 2602-4837

Skull base osteomyelitis

temporal bone osteomyelitis

malignant otitis externa

hyperbaric oxygen therapy

cranial nerve palsy

diabetes mellitus

Sayı

Yazarlar:

Mehmet Murat Günay | Mehmet Furkan Doğan | İlker Akyildiz | Sibel Alicura Tokgöz | Gökhan Toptaş | Muharrem Dağlı | Mustafa Tarık Alay

Yayıncı:

Istanbul University

Ana Başlıklar:

Otorhinolaryngology

Dergi:

The Turkish Journal of Ear Nose and Throat Vol.35 Issue 1, pp.1-9

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344887

pISSN:

2602-4837