Impact of colchicine on inflammatory markers and pregnancy outcomes in familial Mediterranean fever patients

Betül Tokgöz Çakır; Gizem Aktemur; Gülşan Karabay; Zeynep Şeyhanlı; Nazan Vanlı Tonyalı; Furkan Akın; Salime Nur Afsar; Şevki Çelen

Makale detayları

Impact of colchicine on inflammatory markers and pregnancy outcomes in familial Mediterranean fever patients

Yazarlar:

Betül Tokgöz Çakır | Gizem Aktemur | Gülşan Karabay | Zeynep Şeyhanlı | Nazan Vanlı Tonyalı | Furkan Akın | Salime Nur Afsar | Şevki Çelen

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

The European Research Journal Vol.11 Issue 2, pp.172-178

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341277

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: The aim of this study is to evaluate the effect of colchicine use on maternal inflammatory markers and pregnancy outcomes in pregnant women diagnosed with Familial Mediterranean Fever FMF and receiving colchicine therapy. Methods: This retrospective analysis included 42 pregnant women diagnosed with FMF who underwent colchicine treatment and 126 healthy pregnant controls. NeutrophilLymphocyte Ratio NLR, PlateletLymphocyte Ratio PLR, and MonocyteLymphocyte Ratio MLR rates in the blood of the groups in the first trimester, obstetric morbidities and pregnancy outcomes were compared. Results: The patient cohort had markedly reduced hemoglobin levels 12.151.36 vs. 12.801.02 gdL, P0.001, an elevated prevalence of anemia 19 vs. 3, P0.002, and diminished monocyte counts 0.55 vs. 0.61 10⁹L, P0.022 as well as decreased MLR values 0.27 vs. 0.29, P0.020 in comparison to the control group. Other inflammatory markers, pregnancy complications, and neonatal outcomes were similar between the groups p0.05. Conclusions: Colchicine seems to be useful in managing inflammation during FMF pregnancies without negatively affecting pregnancy or neonatal outcomes. Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.

 Objectives: The aim of this study is to evaluate the effect of colchicine use on maternal inflammatory markers and pregnancy outcomes in pregnant women diagnosed with Familial Mediterranean Fever FMF and receiving colchicine therapy. Methods: This retrospective analysis included 42 pregnant women diagnosed with FMF who underwent colchicine treatment and 126 healthy pregnant controls. NeutrophilLymphocyte Ratio NLR, PlateletLymphocyte Ratio PLR, and MonocyteLymphocyte Ratio MLR rates in the blood of the groups in the first trimester, obstetric morbidities and pregnancy outcomes were compared. Results: The patient cohort had markedly reduced hemoglobin levels 12.151.36 vs. 12.801.02 gdL, P0.001, an elevated prevalence of anemia 19 vs. 3, P0.002, and diminished monocyte counts 0.55 vs. 0.61 10⁹L, P0.022 as well as decreased MLR values 0.27 vs. 0.29, P0.020 in comparison to the control group. Other inflammatory markers, pregnancy complications, and neonatal outcomes were similar between the groups p0.05. Conclusions: Colchicine seems to be useful in managing inflammation during FMF pregnancies without negatively affecting pregnancy or neonatal outcomes. Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.

 Objectives: The aim of this study is to evaluate the effect of colchicine use on maternal inflammatory markers and pregnancy outcomes in pregnant women diagnosed with Familial Mediterranean Fever FMF and receiving colchicine therapy. Methods: This retrospective analysis included 42 pregnant women diagnosed with FMF who underwent colchicine treatment and 126 healthy pregnant controls. NeutrophilLymphocyte Ratio NLR, PlateletLymphocyte Ratio PLR, and MonocyteLymphocyte Ratio MLR rates in the blood of the groups in the first trimester, obstetric morbidities and pregnancy outcomes were compared. Results: The patient cohort had markedly reduced hemoglobin levels 12.151.36 vs. 12.801.02 gdL, P0.001, an elevated prevalence of anemia 19 vs. 3, P0.002, and diminished monocyte counts 0.55 vs. 0.61 10⁹L, P0.022 as well as decreased MLR values 0.27 vs. 0.29, P0.020 in comparison to the control group. Other inflammatory markers, pregnancy complications, and neonatal outcomes were similar between the groups p0.05. Conclusions: Colchicine seems to be useful in managing inflammation during FMF pregnancies without negatively affecting pregnancy or neonatal outcomes. Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.

 Objectives: The aim of this study is to evaluate the effect of colchicine use on maternal inflammatory markers and pregnancy outcomes in pregnant women diagnosed with Familial Mediterranean Fever FMF and receiving colchicine therapy. Methods: This retrospective analysis included 42 pregnant women diagnosed with FMF who underwent colchicine treatment and 126 healthy pregnant controls. NeutrophilLymphocyte Ratio NLR, PlateletLymphocyte Ratio PLR, and MonocyteLymphocyte Ratio MLR rates in the blood of the groups in the first trimester, obstetric morbidities and pregnancy outcomes were compared. Results: The patient cohort had markedly reduced hemoglobin levels 12.151.36 vs. 12.801.02 gdL, P0.001, an elevated prevalence of anemia 19 vs. 3, P0.002, and diminished monocyte counts 0.55 vs. 0.61 10⁹L, P0.022 as well as decreased MLR values 0.27 vs. 0.29, P0.020 in comparison to the control group. Other inflammatory markers, pregnancy complications, and neonatal outcomes were similar between the groups p0.05. Conclusions: Colchicine seems to be useful in managing inflammation during FMF pregnancies without negatively affecting pregnancy or neonatal outcomes. Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.

Makale detayları

Impact of colchicine on inflammatory markers and pregnancy outcomes in familial Mediterranean fever patients

Yazarlar:

Betül Tokgöz Çakır | Gizem Aktemur | Gülşan Karabay | Zeynep Şeyhanlı | Nazan Vanlı Tonyalı | Furkan Akın | Salime Nur Afsar | Şevki Çelen

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

The European Research Journal Vol.11 Issue 2, pp.172-178

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341277

pISSN:

2149-3189

Familial Mediterranean fever

colchicine

inflammation

pregnancy

Sayı

Makale detayları

Impact of colchicine on inflammatory markers and pregnancy outcomes in familial Mediterranean fever patients

Yazarlar: Betül Tokgöz Çakır | Gizem Aktemur | Gülşan Karabay | Zeynep Şeyhanlı | Nazan Vanlı Tonyalı | Furkan Akın | Salime Nur Afsar | Şevki Çelen

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Obstetrics and Gynaecology

Dergi: The European Research Journal Vol.11 Issue 2, pp.172-178

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341277

pISSN: 2149-3189

Familial Mediterranean fever

colchicine

inflammation

pregnancy

Sayı

Yazarlar:

Betül Tokgöz Çakır | Gizem Aktemur | Gülşan Karabay | Zeynep Şeyhanlı | Nazan Vanlı Tonyalı | Furkan Akın | Salime Nur Afsar | Şevki Çelen

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

The European Research Journal Vol.11 Issue 2, pp.172-178

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341277

pISSN:

2149-3189