Delta values as a prognostic marker in methanol poisoning: a retrospective cohort study

Murat Duyan; Ali Sarıdaş; Nafis Vural

Makale detayları

Delta values as a prognostic marker in methanol poisoning: a retrospective cohort study

Yazarlar:

Murat Duyan | Ali Sarıdaş | Nafis Vural

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.46-53

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282226

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: The aim of the study was to evaluate the mortality prediction performances of delta bicarbonate, delta anion gap, and delta ratio in methanol poisoning MP cases. Materials and Methods: This clinical study, which followed a cross-sectional study design, involved patients with MP who were still alive when they initially arrived at the emergency department of a tertiary care hospital. Patients were divided into two groups mortality and non-mortality. Patients who died during treatment and follow-up were assigned to the mortality group, while others were assigned to the non-mortality group. Receiver Operating Characteristic ROC analysis was used to determine the cut-off in the diagnostic value measurements of biomarkers predicting mortality. Results: Nine 20 of the 45 patients in the study died during their follow-up. The two groups showed a significant difference in the averages of pH, bicarbonate HCO3-, lactate, anion gap, delta anion gap, delta HCO3-, and delta ratio, but not in the averages of partial carbon dioxide pressure pCO2. In predicting mortality, pH, anion gap, and delta anion gap were found to have outstanding diagnostic power AUC0.9, while HCO3-, delta HCO3-, delta ratio were found to have acceptable diagnostic power AUC: 0.7-0.8. Conclusion: Delta anion gap, delta bicarbonate, and delta ratio can be used as prognostic factors in predicting mortality in MP cases.

 Purpose: The aim of the study was to evaluate the mortality prediction performances of delta bicarbonate, delta anion gap, and delta ratio in methanol poisoning MP cases. Materials and Methods: This clinical study, which followed a cross-sectional study design, involved patients with MP who were still alive when they initially arrived at the emergency department of a tertiary care hospital. Patients were divided into two groups mortality and non-mortality. Patients who died during treatment and follow-up were assigned to the mortality group, while others were assigned to the non-mortality group. Receiver Operating Characteristic ROC analysis was used to determine the cut-off in the diagnostic value measurements of biomarkers predicting mortality. Results: Nine 20 of the 45 patients in the study died during their follow-up. The two groups showed a significant difference in the averages of pH, bicarbonate HCO3-, lactate, anion gap, delta anion gap, delta HCO3-, and delta ratio, but not in the averages of partial carbon dioxide pressure pCO2. In predicting mortality, pH, anion gap, and delta anion gap were found to have outstanding diagnostic power AUC0.9, while HCO3-, delta HCO3-, delta ratio were found to have acceptable diagnostic power AUC: 0.7-0.8. Conclusion: Delta anion gap, delta bicarbonate, and delta ratio can be used as prognostic factors in predicting mortality in MP cases.

 Purpose: The aim of the study was to evaluate the mortality prediction performances of delta bicarbonate, delta anion gap, and delta ratio in methanol poisoning MP cases. Materials and Methods: This clinical study, which followed a cross-sectional study design, involved patients with MP who were still alive when they initially arrived at the emergency department of a tertiary care hospital. Patients were divided into two groups mortality and non-mortality. Patients who died during treatment and follow-up were assigned to the mortality group, while others were assigned to the non-mortality group. Receiver Operating Characteristic ROC analysis was used to determine the cut-off in the diagnostic value measurements of biomarkers predicting mortality. Results: Nine 20 of the 45 patients in the study died during their follow-up. The two groups showed a significant difference in the averages of pH, bicarbonate HCO3-, lactate, anion gap, delta anion gap, delta HCO3-, and delta ratio, but not in the averages of partial carbon dioxide pressure pCO2. In predicting mortality, pH, anion gap, and delta anion gap were found to have outstanding diagnostic power AUC0.9, while HCO3-, delta HCO3-, delta ratio were found to have acceptable diagnostic power AUC: 0.7-0.8. Conclusion: Delta anion gap, delta bicarbonate, and delta ratio can be used as prognostic factors in predicting mortality in MP cases.

 Amaç: Çalışmanın amacı metanol zehirlenmesi MZ vakalarında delta bikarbonat, delta anyon açığı ve delta oranının mortalite tahmin performanslarını değerlendirmektir. Gereç ve Yöntem: Kesitsel bir çalışma tasarımına göre yapılan bu klinik çalışma, üçüncü basamak bir hastanenin acil servisine ilk geldiklerinde hala hayatta olan MZli hastaları içeriyordu. Hastalar ölenler ve sağ kalanlar olarak iki gruba ayrıldı. Tedavi ve takip sırasında ölen hastalar mortalite grubuna, diğerleri non-mortalite grubuna alındı. Mortaliteyi öngören biyobelirteçlerin tanısal değer ölçümlerinde eşik değeri belirlemek için Alıcı İşlem Karakteristiği ROC analizi kullanıldı. Bulgular: Çalışmadaki 45 hastanın dokuzu 20 takipleri sırasında öldü. İki grup, pH, bikarbonat HCO3-, laktat, anyon açığı, delta anyon açığı, delta HCO3- ve delta oranı ortalamalarında önemli bir fark gösterdi, ancak kısmi karbondioksit basıncının pCO2 ortalamalarında göstermedi. Mortaliteyi tahmin etmede pH, anyon açığı, delta anyon açığı üstün tanısal güce sahipken AUC0.9, HCO3-, delta HCO3-, delta oranının kabul edilebilir tanı gücüne sahip olduğu AUC: 0.7-0.8 bulundu. Sonuç: Delta anyon açığı, delta bikarbonat ve delta oranı MZ olgularında mortaliteyi öngörmede prognostik faktörler olarak kullanılabilir.

Makale detayları

Delta values as a prognostic marker in methanol poisoning: a retrospective cohort study

Yazarlar:

Murat Duyan | Ali Sarıdaş | Nafis Vural

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.46-53

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282226

pISSN:

2602-3032

Methanol poisoning

delta ratio

delta anion gap

delta bicarbonate

mortality

Metanol zehirlenmesi

delta oranı

delta anyon açığı

delta bikarbonat

mortalite

Sayı

Makale detayları

Yazarlar: Murat Duyan | Ali Sarıdaş | Nafis Vural

Yayıncı: Cukurova University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Cukurova Medical Journal Vol.48 Issue 1, pp.46-53

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001282226

pISSN: 2602-3032

Sayı

Yazarlar:

Murat Duyan | Ali Sarıdaş | Nafis Vural

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.46-53

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282226

pISSN:

2602-3032