Imidazole Antifungals: A Review of Their Action Mechanisms on Cancerous Cells

Berna KAVAKCIOĞLU YARDIMCI

doi:https://doi.org/10.21448/ijsm.714310

Makale detayları

Imidazole Antifungals: A Review of Their Action Mechanisms on Cancerous Cells

Yazarlar:

Berna KAVAKCIOĞLU YARDIMCI

Yayıncı:

İzzet KARA

Ana Başlıklar:

Yaşam bilimleri

Dergi:

International Journal of Secondary Metabolite 2020 Vol.7 Issue 3, pp.139-159

Belge Tipi:

Makale

Yayın Tarihi:

9/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000471463

Sıklık:

Üç Aylık

eISSN:

2148-6905

DOI:

https://doi.org/10.21448/ijsm.714310

Özet:

 


Imidazoles, together with triazoles, constitute azole sub-group of antifungal drugs which acts by inhibiting cytochrome P450-dependent enzyme, the lanosterol 14-α-demethylase. In addition to their primary use, when it comes to additional anti-cancer function, clotrimazole, econazole and ketoconazole have come to the fore among the imidazoles. Based on the findings up to now, although having different effects, disruption of the glycolytic pathway, blockage of Ca2+ influx and nonspecific inhibition of CYP450 enzymes can be regarded as the main ones responsible for the anti-neoplastic activities of the mentioned drugs, respectively. Considering the advantages of repurposing of drugs with known pharmacology compared to new drug development studies requiring labor, time and cost, it will be extremely important and valuable to continue the clarification of the different mechanisms of these antifungals on cancerous cells and benefit from them especially to increase drug efficacy and overcome drug resistance. In this review, the action mechanisms of imidazole antifungals on cancerous cells and consequently, their potential for use in cancer treatment alone or in combination with conventional therapeutics were discussed in detail.

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Makale detayları

Imidazole Antifungals: A Review of Their Action Mechanisms on Cancerous Cells

Yazarlar: Berna KAVAKCIOĞLU YARDIMCI

Yayıncı: İzzet KARA

Ana Başlıklar: Yaşam bilimleri

Dergi: International Journal of Secondary Metabolite 2020 Vol.7 Issue 3, pp.139-159

Belge Tipi: Makale

Yayın Tarihi: 9/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000471463

Sıklık: Üç Aylık

eISSN: 2148-6905

DOI: https://doi.org/10.21448/ijsm.714310

Sayı

Yazarlar:

Berna KAVAKCIOĞLU YARDIMCI

Yayıncı:

İzzet KARA

Ana Başlıklar:

Yaşam bilimleri

Dergi:

International Journal of Secondary Metabolite 2020 Vol.7 Issue 3, pp.139-159

Belge Tipi:

Makale

Yayın Tarihi:

9/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000471463

Sıklık:

Üç Aylık

eISSN:

2148-6905

DOI:

https://doi.org/10.21448/ijsm.714310