A new tool for QT interval analysis during sleep in healthy and obstructive sleep apnea subjects: a study on women

Kemal Alican KAYA; Bülent YILMAZ

Makale detayları

A new tool for QT interval analysis during sleep in healthy and obstructive sleep apnea subjects: a study on women

Yazarlar:

Kemal Alican KAYA | Bülent YILMAZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Electrical Engineering and Computer Science 2013 Vol.21 Issue 5, pp.1504-1513

Belge Tipi:

Makale

Yayın Tarihi:

4/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000743246

Sıklık:

İki Aylık

eISSN:

1303-6203

pISSN:

1300-0632

Özet:

 

By monitoring the Q wave/T wave (QT) interval computed from   electrocardiography (ECG) signals during sleep, it is possible to create a   link between the ventricular repolarization and sleep stages. In this study,   we aimed to find a robust and simple approach to automatically determine the   fiducials on each 30-s sleep epoch, such as the Q, R, and T-end points, on   long sleep ECG recordings in order to statistically analyze the effect of   obstructive sleep apnea (OSA) and sleep stages on QT intervals. This is a   retrospective study in which the ECG data extracted from the polysomnography   recordings of 7 healthy women and 5 women with OSA, acquired in a sleep   laboratory, were used. Experts annotated the sleep stage and OSA presence   information for each 30-s epoch. Later, we visually selected epochs with   clean signals from a total of 8324 epochs. On the selected epochs, we   determined R peaks on each heartbeat, and by aligning each ECG portion   corresponding to a heartbeat using those R points, we computed an average   ECG signal for each epoch. On the average ECG signals, we developed a novel   approach to find the Q and T-end points. With the help of Bazzet's formula,   we computed the corrected QT interval (QTc) values for each epoch using the   QT and the median RR interval. Finally, we analyzed the QTc values for the   different sleep stages and healthy or OSA groups. We employed statistical   approaches such as the Mann--Whitney U test, Freidman's test, and the   Wilcoxon signed-rank test. As a result of this study, we found that OSA has   a prolongation effect on the total duration of the ventricular   depolarization and repolarization. We also observed that the QTc values   computed in each sleep stage were significantly different between the   healthy and OSA groups. Additionally, we discovered that within the healthy   group, the QTc values were distinctive in the different sleep stages.

 

By monitoring the Q wave/T wave (QT) interval computed from   electrocardiography (ECG) signals during sleep, it is possible to create a   link between the ventricular repolarization and sleep stages. In this study,   we aimed to find a robust and simple approach to automatically determine the   fiducials on each 30-s sleep epoch, such as the Q, R, and T-end points, on   long sleep ECG recordings in order to statistically analyze the effect of   obstructive sleep apnea (OSA) and sleep stages on QT intervals. This is a   retrospective study in which the ECG data extracted from the polysomnography   recordings of 7 healthy women and 5 women with OSA, acquired in a sleep   laboratory, were used. Experts annotated the sleep stage and OSA presence   information for each 30-s epoch. Later, we visually selected epochs with   clean signals from a total of 8324 epochs. On the selected epochs, we   determined R peaks on each heartbeat, and by aligning each ECG portion   corresponding to a heartbeat using those R points, we computed an average   ECG signal for each epoch. On the average ECG signals, we developed a novel   approach to find the Q and T-end points. With the help of Bazzet's formula,   we computed the corrected QT interval (QTc) values for each epoch using the   QT and the median RR interval. Finally, we analyzed the QTc values for the   different sleep stages and healthy or OSA groups. We employed statistical   approaches such as the Mann--Whitney U test, Freidman's test, and the   Wilcoxon signed-rank test. As a result of this study, we found that OSA has   a prolongation effect on the total duration of the ventricular   depolarization and repolarization. We also observed that the QTc values   computed in each sleep stage were significantly different between the   healthy and OSA groups. Additionally, we discovered that within the healthy   group, the QTc values were distinctive in the different sleep stages.

Makale detayları

A new tool for QT interval analysis during sleep in healthy and obstructive sleep apnea subjects: a study on women

Yazarlar: Kemal Alican KAYA | Bülent YILMAZ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Electrical Engineering and Computer Science 2013 Vol.21 Issue 5, pp.1504-1513

Belge Tipi: Makale

Yayın Tarihi: 4/2013

Belge Dili: Türkçe

Document ID (Org No.): 2000743246

Sıklık: İki Aylık

eISSN: 1303-6203

pISSN: 1300-0632

Sayı

Yazarlar:

Kemal Alican KAYA | Bülent YILMAZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Electrical Engineering and Computer Science 2013 Vol.21 Issue 5, pp.1504-1513

Belge Tipi:

Makale

Yayın Tarihi:

4/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000743246

Sıklık:

İki Aylık

eISSN:

1303-6203

pISSN:

1300-0632