Thiol-Disulfide Balance in Patients with Dissociative Identity Disorder

Ülker Atılan Fedai; Hakim Çelik; Seyhan Taşkın; Mehmet Asoğlu; Esat Sabuncu

Makale detayları

Thiol-Disulfide Balance in Patients with Dissociative Identity Disorder

Yazarlar:

Ülker Atılan Fedai | Hakim Çelik | Seyhan Taşkın | Mehmet Asoğlu | Esat Sabuncu

Yayıncı:

Harran University

Ana Başlıklar:

Psikiyatri

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.544-550

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001352425

pISSN:

1304-9623

Anahtar kelimeler:

Özet:

 Background: This study aimed to evaluate thiol-disulfide homeostasis TDH parameters in individuals diag-nosed with Dissociative Identity Disorder DID to investigate whether there is a disruption in oxidative stress levels and to examine the relationship of these biological changes with DID. Materials and Methods: Fifty-six patients diagnosed with DID according to DSM-5 criteria and 43 healthy volunteers without any psychiatric disorders were included in the study. After 12 hours of fasting, blood samples were collected from all participants to measure TDH parameters. Measurements were performed using a colorimetric method, and total thiol, native thiol, disulfide levels, and their ratios were calculated. Participants were also assessed with the Dissociative Experiences Scale DES and the Childhood Trauma Questionnaire CTQ. Data were analyzed statistically using independent samples t-test, Mann-Whitney U test, chi-square test, and correlation analyses. Results: In the DID group, total thiol p0.001, disulfide levels p0.001, and disulfidetotal thiol ratios p0.02 were significantly lower compared to the healthy control group. In contrast, the native thioltotal thiol ratio was significantly higher in the DID group than in the control group p0.02. However, correla-tion analyses revealed no significant relationship between TDH parameters and DES or CTQ scores within the DID group. Conclusions: This study demonstrates that thiol-disulfide homeostasis is disrupted in individuals with DID. The decrease in total thiol levels indicates reduced antioxidant capacity, while the concomitant decrease in disulfide levels suggests insufficient activation of the redox system. The results highlight the potential of thiol-disulfide homeostasis balance as a biomarker in understanding the biological basis of DID and unders-core the need for further studies with larger samples to support these findings.

 Background: This study aimed to evaluate thiol-disulfide homeostasis TDH parameters in individuals diag-nosed with Dissociative Identity Disorder DID to investigate whether there is a disruption in oxidative stress levels and to examine the relationship of these biological changes with DID. Materials and Methods: Fifty-six patients diagnosed with DID according to DSM-5 criteria and 43 healthy volunteers without any psychiatric disorders were included in the study. After 12 hours of fasting, blood samples were collected from all participants to measure TDH parameters. Measurements were performed using a colorimetric method, and total thiol, native thiol, disulfide levels, and their ratios were calculated. Participants were also assessed with the Dissociative Experiences Scale DES and the Childhood Trauma Questionnaire CTQ. Data were analyzed statistically using independent samples t-test, Mann-Whitney U test, chi-square test, and correlation analyses. Results: In the DID group, total thiol p0.001, disulfide levels p0.001, and disulfidetotal thiol ratios p0.02 were significantly lower compared to the healthy control group. In contrast, the native thioltotal thiol ratio was significantly higher in the DID group than in the control group p0.02. However, correla-tion analyses revealed no significant relationship between TDH parameters and DES or CTQ scores within the DID group. Conclusions: This study demonstrates that thiol-disulfide homeostasis is disrupted in individuals with DID. The decrease in total thiol levels indicates reduced antioxidant capacity, while the concomitant decrease in disulfide levels suggests insufficient activation of the redox system. The results highlight the potential of thiol-disulfide homeostasis balance as a biomarker in understanding the biological basis of DID and unders-core the need for further studies with larger samples to support these findings.

 Background: This study aimed to evaluate thiol-disulfide homeostasis TDH parameters in individuals diag-nosed with Dissociative Identity Disorder DID to investigate whether there is a disruption in oxidative stress levels and to examine the relationship of these biological changes with DID. Materials and Methods: Fifty-six patients diagnosed with DID according to DSM-5 criteria and 43 healthy volunteers without any psychiatric disorders were included in the study. After 12 hours of fasting, blood samples were collected from all participants to measure TDH parameters. Measurements were performed using a colorimetric method, and total thiol, native thiol, disulfide levels, and their ratios were calculated. Participants were also assessed with the Dissociative Experiences Scale DES and the Childhood Trauma Questionnaire CTQ. Data were analyzed statistically using independent samples t-test, Mann-Whitney U test, chi-square test, and correlation analyses. Results: In the DID group, total thiol p0.001, disulfide levels p0.001, and disulfidetotal thiol ratios p0.02 were significantly lower compared to the healthy control group. In contrast, the native thioltotal thiol ratio was significantly higher in the DID group than in the control group p0.02. However, correla-tion analyses revealed no significant relationship between TDH parameters and DES or CTQ scores within the DID group. Conclusions: This study demonstrates that thiol-disulfide homeostasis is disrupted in individuals with DID. The decrease in total thiol levels indicates reduced antioxidant capacity, while the concomitant decrease in disulfide levels suggests insufficient activation of the redox system. The results highlight the potential of thiol-disulfide homeostasis balance as a biomarker in understanding the biological basis of DID and unders-core the need for further studies with larger samples to support these findings.

 Amaç: Bu çalışmanın amacı, Dissosiyatif Kimlik Bozukluğu DKB tanılı bireylerde tiyol-disülfid homeostazı TDH parametrelerini değerlendirerek oksidatif stres düzeylerinde bozulma olup olmadığını araştırmak ve bu biyolojik değişikliklerin DKB ile ilişkisini incelemektir. Materyal ve Metod: DSM-5 kriterlerine göre DKB tanısı konan 56 hasta ile herhangi bir psikiyatrik bozukluğu bulunmayan 43 sağlıklı gönüllü çalışmaya dahil edilmiştir. Katılımcılardan 12 saatlik açlık sonrası kan örnek-leri alınarak tiyol-disülfid homeostazı parametreleri ölçülmüştür. Ölçümler kolorimetrik yöntemle gerçek-leştirilmiş, toplam tiyol, doğal tiyol ve disülfid düzeyleri ile bunların oranları hesaplanmıştır. Katılımcılara Dissosiyatif Yaşantılar Ölçeği DYÖ ve Çocukluk Çağı Travmaları Ölçeği ÇÇTÖ uygulanmıştır. Veriler istatistik-sel olarak bağımsız gruplar t testi, Mann-Whitney U testi, ki-kare testi ve korelasyon analizleri kullanılarak değerlendirilmiştir. Bulgular: DKB grubunda toplam tiyol p0.001 ve disülfid düzeyleri p0.001 ile disülfidtoplam tiyol oranları p0.02, sağlıklı kontrol grubuna göre istatistiksel olarak anlamlı derecede düşüktü. Doğal ti-yoltoplam tiyol oranı ise DKB grubunda kontrol grubuna kıyasla anlamlı derecede yüksekti p0.02. Kore-lasyon analizlerinde ise DKB grubunda TDH parametreleri ile DYÖ ve ÇÇTÖ skorları arasında anlamlı bir ilişki saptanmamıştır. Sonuç: Bu çalışma, DKB tanılı bireylerde tiyol-disülfid homeostazının bozulduğunu göstermektedir. Toplam tiyol düzeylerindeki düşüş, antioksidan kapasitede azalma olduğunu düşündürürken, disülfid düzeylerinin de düşük bulunması redoks sisteminin yeterince aktive olamadığını düşündürmektedir. Bulgular, DKBnin biyolojik temelini anlamada tiyol-disülfid homeostazı dengesinin potansiyel bir biyobelirteç olabileceğini göstermekte olup, daha geniş örneklemlerle yapılacak çalışmalarla desteklenmesi gerekmektedir.

Makale detayları

Thiol-Disulfide Balance in Patients with Dissociative Identity Disorder

Yazarlar:

Ülker Atılan Fedai | Hakim Çelik | Seyhan Taşkın | Mehmet Asoğlu | Esat Sabuncu

Yayıncı:

Harran University

Ana Başlıklar:

Psikiyatri

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.544-550

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001352425

pISSN:

1304-9623

Dissociative Identity Disorder

Thiol-Disulfide Homeostasis

Oxidative StressDissosiyatif Kimlik Bozukluğu

Tiyol-Disülfid Homeostazı

Oksidatif Stres

Sayı

Makale detayları

Thiol-Disulfide Balance in Patients with Dissociative Identity Disorder

Yazarlar: Ülker Atılan Fedai | Hakim Çelik | Seyhan Taşkın | Mehmet Asoğlu | Esat Sabuncu

Yayıncı: Harran University

Ana Başlıklar: Psikiyatri

Dergi: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.544-550

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001352425

pISSN: 1304-9623

Dissociative Identity Disorder

Thiol-Disulfide Homeostasis

Oxidative StressDissosiyatif Kimlik Bozukluğu

Tiyol-Disülfid Homeostazı

Oksidatif Stres

Sayı

Yazarlar:

Ülker Atılan Fedai | Hakim Çelik | Seyhan Taşkın | Mehmet Asoğlu | Esat Sabuncu

Yayıncı:

Harran University

Ana Başlıklar:

Psikiyatri

Dergi:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.22 Issue 3, pp.544-550

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001352425

pISSN:

1304-9623