The effect of the pretreatment systemic immune-inflammatory index and C-reactive protein-to-albumin ratio on prognosis in pediatric patients with IgA vasculitis

Vildan Güngörer; Işık Dişçi; Şükrü Arslan

Makale detayları

The effect of the pretreatment systemic immune-inflammatory index and C-reactive protein-to-albumin ratio on prognosis in pediatric patients with IgA vasculitis

Yazarlar:

Vildan Güngörer | Işık Dişçi | Şükrü Arslan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.441-448

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286259

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aim: Indices related to blood parameters that indicate inflammation have recently started to be used in determining prognosis for many diseases. Visceral involvement is the most important factor affecting prognosis in immunoglobulin A vasculitis IgAV. In this study, we sought to explore the value of the systemic immune-inflammation index SII and the C-reactive protein-to-albumin ratio CAR in predicting visceral involvement in IgAV. Material and Method: Patients diagnosed with IgAV who had gastrointestinal, renal, testicular, or central nervous system involvement were considered patients with visceral involvement. All patients with IgAV were divided into two groups, those with and without visceral involvement. The effect of SII and CAR in predicting visceral involvement was evaluated by logistic regression analysis. Results: We found that in the summertime, the percentage of patients with visceral involvement was significantly higher than those without visceral involvement p0.010. The rates of the recurrence of the disease, arthralgia, arthritis, and fever were significantly greater in those with visceral involvement p0.032, p0.001, p0.027, and p0.019, respectively. SII, CAR, and neutrophil-to-lymphocyte ratio NLR values were significantly higher in the patients with visceral involvement p0.017, p0.046, and p0.008, respectively. The results of the univariate analysis showed that the SII and NLR were significant predictors of visceral involvement OR: 1.001, 95 CI: 1.000-1.001, p0.036; OR: 1.344, 95 CI: 1.053-1.715, p0.018, respectively. We found that NLR was of greater value than SII in terms of predicting visceral involvement. Conclusion: SII can be a valuable indicator for predicting visceral involvement in IgAV. However, CAR was not found significant in predicting visceral involvement.

 Aim: Indices related to blood parameters that indicate inflammation have recently started to be used in determining prognosis for many diseases. Visceral involvement is the most important factor affecting prognosis in immunoglobulin A vasculitis IgAV. In this study, we sought to explore the value of the systemic immune-inflammation index SII and the C-reactive protein-to-albumin ratio CAR in predicting visceral involvement in IgAV. Material and Method: Patients diagnosed with IgAV who had gastrointestinal, renal, testicular, or central nervous system involvement were considered patients with visceral involvement. All patients with IgAV were divided into two groups, those with and without visceral involvement. The effect of SII and CAR in predicting visceral involvement was evaluated by logistic regression analysis. Results: We found that in the summertime, the percentage of patients with visceral involvement was significantly higher than those without visceral involvement p0.010. The rates of the recurrence of the disease, arthralgia, arthritis, and fever were significantly greater in those with visceral involvement p0.032, p0.001, p0.027, and p0.019, respectively. SII, CAR, and neutrophil-to-lymphocyte ratio NLR values were significantly higher in the patients with visceral involvement p0.017, p0.046, and p0.008, respectively. The results of the univariate analysis showed that the SII and NLR were significant predictors of visceral involvement OR: 1.001, 95 CI: 1.000-1.001, p0.036; OR: 1.344, 95 CI: 1.053-1.715, p0.018, respectively. We found that NLR was of greater value than SII in terms of predicting visceral involvement. Conclusion: SII can be a valuable indicator for predicting visceral involvement in IgAV. However, CAR was not found significant in predicting visceral involvement.

 Aim: Indices related to blood parameters that indicate inflammation have recently started to be used in determining prognosis for many diseases. Visceral involvement is the most important factor affecting prognosis in immunoglobulin A vasculitis IgAV. In this study, we sought to explore the value of the systemic immune-inflammation index SII and the C-reactive protein-to-albumin ratio CAR in predicting visceral involvement in IgAV. Material and Method: Patients diagnosed with IgAV who had gastrointestinal, renal, testicular, or central nervous system involvement were considered patients with visceral involvement. All patients with IgAV were divided into two groups, those with and without visceral involvement. The effect of SII and CAR in predicting visceral involvement was evaluated by logistic regression analysis. Results: We found that in the summertime, the percentage of patients with visceral involvement was significantly higher than those without visceral involvement p0.010. The rates of the recurrence of the disease, arthralgia, arthritis, and fever were significantly greater in those with visceral involvement p0.032, p0.001, p0.027, and p0.019, respectively. SII, CAR, and neutrophil-to-lymphocyte ratio NLR values were significantly higher in the patients with visceral involvement p0.017, p0.046, and p0.008, respectively. The results of the univariate analysis showed that the SII and NLR were significant predictors of visceral involvement OR: 1.001, 95 CI: 1.000-1.001, p0.036; OR: 1.344, 95 CI: 1.053-1.715, p0.018, respectively. We found that NLR was of greater value than SII in terms of predicting visceral involvement. Conclusion: SII can be a valuable indicator for predicting visceral involvement in IgAV. However, CAR was not found significant in predicting visceral involvement.

 Aim: Indices related to blood parameters that indicate inflammation have recently started to be used in determining prognosis for many diseases. Visceral involvement is the most important factor affecting prognosis in immunoglobulin A vasculitis IgAV. In this study, we sought to explore the value of the systemic immune-inflammation index SII and the C-reactive protein-to-albumin ratio CAR in predicting visceral involvement in IgAV. Material and Method: Patients diagnosed with IgAV who had gastrointestinal, renal, testicular, or central nervous system involvement were considered patients with visceral involvement. All patients with IgAV were divided into two groups, those with and without visceral involvement. The effect of SII and CAR in predicting visceral involvement was evaluated by logistic regression analysis. Results: We found that in the summertime, the percentage of patients with visceral involvement was significantly higher than those without visceral involvement p0.010. The rates of the recurrence of the disease, arthralgia, arthritis, and fever were significantly greater in those with visceral involvement p0.032, p0.001, p0.027, and p0.019, respectively. SII, CAR, and neutrophil-to-lymphocyte ratio NLR values were significantly higher in the patients with visceral involvement p0.017, p0.046, and p0.008, respectively. The results of the univariate analysis showed that the SII and NLR were significant predictors of visceral involvement OR: 1.001, 95 CI: 1.000-1.001, p0.036; OR: 1.344, 95 CI: 1.053-1.715, p0.018, respectively. We found that NLR was of greater value than SII in terms of predicting visceral involvement. Conclusion: SII can be a valuable indicator for predicting visceral involvement in IgAV. However, CAR was not found significant in predicting visceral involvement.

Makale detayları

The effect of the pretreatment systemic immune-inflammatory index and C-reactive protein-to-albumin ratio on prognosis in pediatric patients with IgA vasculitis

Yazarlar: Vildan Güngörer | Işık Dişçi | Şükrü Arslan

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.441-448

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286259

pISSN: 2636-8579

IgA vasculitis

inflammation

prognosis

IgA vasculitis

inflammation

prognosis

Sayı

Yazarlar:

Vildan Güngörer | Işık Dişçi | Şükrü Arslan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.441-448

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286259

pISSN:

2636-8579