The properties of nefopam as analgesic co-administration  with caffeine as adjuvant in induced pain in mice

N.A.

Makale detayları

The properties of nefopam as analgesic co-administration with caffeine as adjuvant in induced pain in mice

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1581-1591

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347587

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 This study aimed to evaluate nefopams analgesic properties, explore caffeines potential adjuvant effects, and examine its impact on renal and hepatic function. The study involved 56 female albino mice, divided into seven groups: Group A, as the control group, received distilled water; Group B received 0.75 mg per body weight of nefopam orally; Group C received 0.71 mgB.W. of nefopam and 0.125 mgB.W. of caffeine; Group D received 0.67 mgB.W. of nefopam and 0.25 mgB.W. of caffeine; and Group E received 0.63 mgB.W. of nefopam and 0.37 mgB.W. of caffeine. Group F received 0.6 mgB.W. nefopam and 0.5 mgB.W. caffeine orally; Group G received 0.56 mgB.W. of nefopam and 0.62 mgB.W. of caffeine. Several experimental models have been utilised to investigate the analgesic advantages. The hot plate test is a method used to assess the response time to thermal stimuli. Group D produced the most prolonged response duration to thermal stimuli, namely thermal pain, while the writhing test involves the injection of acetic acid, resulting in a significant decrease in the frequency of writhing observed in Group D. Inconclusion, Nefopam demonstrated analgesic properties in all experimental groups, even when augmented with caffeine, without any observed changes in renal or liver function.

 This study aimed to evaluate nefopams analgesic properties, explore caffeines potential adjuvant effects, and examine its impact on renal and hepatic function. The study involved 56 female albino mice, divided into seven groups: Group A, as the control group, received distilled water; Group B received 0.75 mg per body weight of nefopam orally; Group C received 0.71 mgB.W. of nefopam and 0.125 mgB.W. of caffeine; Group D received 0.67 mgB.W. of nefopam and 0.25 mgB.W. of caffeine; and Group E received 0.63 mgB.W. of nefopam and 0.37 mgB.W. of caffeine. Group F received 0.6 mgB.W. nefopam and 0.5 mgB.W. caffeine orally; Group G received 0.56 mgB.W. of nefopam and 0.62 mgB.W. of caffeine. Several experimental models have been utilised to investigate the analgesic advantages. The hot plate test is a method used to assess the response time to thermal stimuli. Group D produced the most prolonged response duration to thermal stimuli, namely thermal pain, while the writhing test involves the injection of acetic acid, resulting in a significant decrease in the frequency of writhing observed in Group D. Inconclusion, Nefopam demonstrated analgesic properties in all experimental groups, even when augmented with caffeine, without any observed changes in renal or liver function.

 This study aimed to evaluate nefopams analgesic properties, explore caffeines potential adjuvant effects, and examine its impact on renal and hepatic function. The study involved 56 female albino mice, divided into seven groups: Group A, as the control group, received distilled water; Group B received 0.75 mg per body weight of nefopam orally; Group C received 0.71 mgB.W. of nefopam and 0.125 mgB.W. of caffeine; Group D received 0.67 mgB.W. of nefopam and 0.25 mgB.W. of caffeine; and Group E received 0.63 mgB.W. of nefopam and 0.37 mgB.W. of caffeine. Group F received 0.6 mgB.W. nefopam and 0.5 mgB.W. caffeine orally; Group G received 0.56 mgB.W. of nefopam and 0.62 mgB.W. of caffeine. Several experimental models have been utilised to investigate the analgesic advantages. The hot plate test is a method used to assess the response time to thermal stimuli. Group D produced the most prolonged response duration to thermal stimuli, namely thermal pain, while the writhing test involves the injection of acetic acid, resulting in a significant decrease in the frequency of writhing observed in Group D. Inconclusion, Nefopam demonstrated analgesic properties in all experimental groups, even when augmented with caffeine, without any observed changes in renal or liver function.

 This study aimed to evaluate nefopams analgesic properties, explore caffeines potential adjuvant effects, and examine its impact on renal and hepatic function. The study involved 56 female albino mice, divided into seven groups: Group A, as the control group, received distilled water; Group B received 0.75 mg per body weight of nefopam orally; Group C received 0.71 mgB.W. of nefopam and 0.125 mgB.W. of caffeine; Group D received 0.67 mgB.W. of nefopam and 0.25 mgB.W. of caffeine; and Group E received 0.63 mgB.W. of nefopam and 0.37 mgB.W. of caffeine. Group F received 0.6 mgB.W. nefopam and 0.5 mgB.W. caffeine orally; Group G received 0.56 mgB.W. of nefopam and 0.62 mgB.W. of caffeine. Several experimental models have been utilised to investigate the analgesic advantages. The hot plate test is a method used to assess the response time to thermal stimuli. Group D produced the most prolonged response duration to thermal stimuli, namely thermal pain, while the writhing test involves the injection of acetic acid, resulting in a significant decrease in the frequency of writhing observed in Group D. Inconclusion, Nefopam demonstrated analgesic properties in all experimental groups, even when augmented with caffeine, without any observed changes in renal or liver function.

Makale detayları

The properties of nefopam as analgesic co-administration with caffeine as adjuvant in induced pain in mice

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1581-1591

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347587

pISSN:

2630-6344

Analgesic

Nefopam

Caffeine

Hot Plate

Acetic acid

Renal test

Hepatic test

Sayı

Makale detayları

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.28 Issue 5, pp.1581-1591

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347587

pISSN: 2630-6344

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 5, pp.1581-1591

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347587

pISSN:

2630-6344