Long-Term Effects of Neonatal LPS and Caspase -1 İnhibitor Administration on Gonadotropin Levels and Testicular Histology in Rats

Tuba ÖZGÖÇER; Sedat YILDIZ; Azibe YILDIZ; Nigar VARDI

doi:https://doi.org/10.37990/medr.783590

Makale detayları

Long-Term Effects of Neonatal LPS and Caspase -1 İnhibitor Administration on Gonadotropin Levels and Testicular Histology in Rats

Yazarlar:

Tuba ÖZGÖÇER | Sedat YILDIZ | Azibe YILDIZ | Nigar VARDI

Yayıncı:

Zülal ÖNER

Ana Başlıklar:

Hastalıklar

Dergi:

Medical Records 2021 Vol.3 Issue 1, pp.22-28

Belge Tipi:

Makale

Yayın Tarihi:

1/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000544270

Sıklık:

Üç Yıllık

eISSN:

2687-4555

DOI:

https://doi.org/10.37990/medr.783590

Özet:

 

Aim: Endotoxins (lipopolysaccharides, LPS) negatively affect reproduction by decreasing gonadotropin levels in the acute period. The aim of this study is to investigate the long-term effects of re-injection of endotoxin in adulthood on gonadotropin release and testicular tissue in male rats injected with endotoxin with IL-1 beta inhibitor (Q-Vd-OPh; caspase-1 inhibitor, Cİ) in the neonatal period.Material and Methods: On postnatal day 7, male rat pups were injected once with either Salin, LPS (50µg/kg), LPS (50µg/kg)+CI (1mg/kg). On postnatal 10 months, these rats were either injected with saline or LPS (50 µg/kg). 10 days after these injections, serum samples and testicular tissues were taken and the experiment was terminated.Results: Respectively, control, Salin+LPS, LPS+Salin; LPS+LPS; LPS(CI)+Salin and LPS(CI)+LPS groups were 18.8±1.6; 11.3±1.2; 23.4±2.0; 22.2±1.2 ve 23.6±1.4 ng/ml for serum LH concentrations (p0,05). Seminiferous tubule damage was observed in LPS groups (p<0,05).Conclusion: This research demonstrates (1) neonatal LPS injections do not negatively affect gonadotropin release in the long term, (2) IL-1 β plays a critical role in the programming of reproduction, especially in terms of testicular histology.

Makale detayları

Long-Term Effects of Neonatal LPS and Caspase -1 İnhibitor Administration on Gonadotropin Levels and Testicular Histology in Rats

Yazarlar: Tuba ÖZGÖÇER | Sedat YILDIZ | Azibe YILDIZ | Nigar VARDI

Yayıncı: Zülal ÖNER

Ana Başlıklar: Hastalıklar

Dergi: Medical Records 2021 Vol.3 Issue 1, pp.22-28

Belge Tipi: Makale

Yayın Tarihi: 1/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000544270

Sıklık: Üç Yıllık

eISSN: 2687-4555

DOI: https://doi.org/10.37990/medr.783590

Sayı

Yazarlar:

Tuba ÖZGÖÇER | Sedat YILDIZ | Azibe YILDIZ | Nigar VARDI

Yayıncı:

Zülal ÖNER

Ana Başlıklar:

Hastalıklar

Dergi:

Medical Records 2021 Vol.3 Issue 1, pp.22-28

Belge Tipi:

Makale

Yayın Tarihi:

1/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000544270

Sıklık:

Üç Yıllık

eISSN:

2687-4555

DOI:

https://doi.org/10.37990/medr.783590