COMBINATIONAL EFFECT OF ALYSSUM PATERI SUBSP. PROSTRATUM AND 5-FU ON HT-29 AND PC-3 CANCER CELL LINES

Mehmet Kadir ERDOĞAN; Lütfi BEHÇET

Makale detayları

COMBINATIONAL EFFECT OF ALYSSUM PATERI SUBSP. PROSTRATUM AND 5-FU ON HT-29 AND PC-3 CANCER CELL LINES

Yazarlar:

Mehmet Kadir ERDOĞAN | Lütfi BEHÇET

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-135

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835321

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711

Özet:

 


Brassicaceae
(Cruciferae) family is widely distributed in the world with 350 genera and
about 3500 species. The species of this family have many health-promoting
phytochemicals such as minerals, fat, vitamins, phenolic compounds and soluble
sugars, and different species of Brassicaceae reduce the oxidative damage and
have anticarcinogenetic, antioxidant, antimicrobial, antiinflammatory effects.
A. pateri subsp. prostratum is a perennial member of Brassicaceae.
6,10,14-trimethyl-2-pentadecanone (22.09 %), 1,8-cineole (11.91 %),
thiobis-methane (6.43 %), 2,6,10-trimethylpentadecane (6.05 %) and hexadecane
(4.19 %) is the major constituents of the essential oil of A. pateri subsp.
prostratum. 




The aim of this
study was examined the antiproliferative and apoptotic effect of hexane,
chloroform, ethyl acetate and methanol extracts from the aerial parts of
Alyssum pateri Nyár subsp. prostratum (Nyár) Dudley, which growing in Turkey,
and combination of these extracts with 5-FU. Cell Proliferation Kit I (MTT) and
Cell Death Detection Elisa Kit from Roche (Roche Diagnostics, Mannheim,
Germany) were used to determine the apoptotic and cytotoxic effect of Alyssum
pateri subsp. prostratum extracts on HT-29 human colorectal cancer and PC-3
human prostate cancer cell lines. Propidium iodide and ethidium bromide were
used for monitoring the apoptotic and necrotic cells.

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Makale detayları

COMBINATIONAL EFFECT OF ALYSSUM PATERI SUBSP. PROSTRATUM AND 5-FU ON HT-29 AND PC-3 CANCER CELL LINES

Yazarlar: Mehmet Kadir ERDOĞAN | Lütfi BEHÇET

Yayıncı: Engin TUTKUN

Dergi: The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-135

Belge Tipi: Makale

Yayın Tarihi: 2/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000835321

Sıklık: Üç Aylık

eISSN: 2149-4711

pISSN: 2149-4711

Sayı

Yazarlar:

Mehmet Kadir ERDOĞAN | Lütfi BEHÇET

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-135

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835321

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711