Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats

Züleyha DOĞANYİĞİT; Emin KAYMAK; Aslı OKAN; Dilek PANDIR; Sibel SİLİCİ

Makale detayları

Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats

Yazarlar:

Züleyha DOĞANYİĞİT | Emin KAYMAK | Aslı OKAN | Dilek PANDIR | Sibel SİLİCİ

Yayıncı:

Hacettepe University

Ana Başlıklar:

Tarım | Yaşam bilimleri

Dergi:

Mellifera 2020 Vol.20 Issue 1, pp.3-15

Belge Tipi:

Makale

Yayın Tarihi:

6/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000755697

Sıklık:

İki Yıllık

pISSN:

1302-5821

Özet:

 

Apilarnil is a bee product that has attracted attention due to its beneficial biological properties recently. This study aimed to investigate the effect of apilarnil (API) on endotoxin-induced lung injury. For the study, 64 adult male Sprague dawley rats were divided into eight groups; control, 0.2, 0.4 and 0.8 g / kg API treated groups by gavage for 10 days, 30 mg / kg lipopolysaccharide (LPS) administered intraperitoneally (single dose), LPS + 0.2, LPS + 0.4 and LPS + 0.8 g / kg API applied groups. In histopathological evaluation, hyperemia, intra-alveolar hemorrhage, cellular infiltration, and increased cellular abnormal proliferation were observed in the lung samples of the LPS group. It was found that the lung samples of LPS + 0,4 and LPS + 0,8 API groups decreased statistically significant compared to the LPS group. The number of TUNEL positive cells observed in both LPS and API treated groups showed a statistically significant decrease compared to the LPS group. In comet test, 0,8 API group was found to be reduced more in tail % DNA and tail length when LPS + API treated groups were compared with LPS group. In conclusion, the API applied to rats can prevent LPS-induced lung injury.

Makale detayları

Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats

Yazarlar: Züleyha DOĞANYİĞİT | Emin KAYMAK | Aslı OKAN | Dilek PANDIR | Sibel SİLİCİ

Yayıncı: Hacettepe University

Ana Başlıklar: Tarım | Yaşam bilimleri

Dergi: Mellifera 2020 Vol.20 Issue 1, pp.3-15

Belge Tipi: Makale

Yayın Tarihi: 6/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000755697

Sıklık: İki Yıllık

pISSN: 1302-5821

Sayı

Yazarlar:

Züleyha DOĞANYİĞİT | Emin KAYMAK | Aslı OKAN | Dilek PANDIR | Sibel SİLİCİ

Yayıncı:

Hacettepe University

Ana Başlıklar:

Tarım | Yaşam bilimleri

Dergi:

Mellifera 2020 Vol.20 Issue 1, pp.3-15

Belge Tipi:

Makale

Yayın Tarihi:

6/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000755697

Sıklık:

İki Yıllık

pISSN:

1302-5821