Synthesis and Characterization of New Shiff Bases Containing N-Benzylethylenediamine Unit and Determination of Their Cytotoxic Effects on Human Colon Cancer Cells

Fatma Hamurcu

Makale detayları

Synthesis and Characterization of New Shiff Bases Containing N-Benzylethylenediamine Unit and Determination of Their Cytotoxic Effects on Human Colon Cancer Cells

Yazarlar:

Fatma Hamurcu

Yayıncı:

Gazi University

Ana Başlıklar:

Biyoinorganik Kimya

Dergi:

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji Vol.11 Issue 3, pp.857-866

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001299415

pISSN:

2147-9526

Anahtar kelimeler:

Özet:

 In this study, three new Schiff bases were synthesized as a result of the condensation reaction of N-benzyl ethylene diamine and 2-Hydroxy-5-methylbenzaldehyde, 2-Hydroxy-5-methylacetophenone, 2-Hydroxy-5-chloroacetophenone compounds L1, L2 and L3. The structures of the newly synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR and elemental analysis methods. Next, the cytotoxic activities of the obtained compounds were investigated using human colon cancer cell lines Caco-2, colon and HT-29 colon carcinoma cell lines. The results obtained were compared with the standard chemotherapy drug 5-Fluorouracil 5-FU. According to cytotoxicity results, L2 compound was found to have the highest anticancer activity in Caco-2 column and HT-29 column cell lines.

 In this study, three new Schiff bases were synthesized as a result of the condensation reaction of N-benzyl ethylene diamine and 2-Hydroxy-5-methylbenzaldehyde, 2-Hydroxy-5-methylacetophenone, 2-Hydroxy-5-chloroacetophenone compounds L1, L2 and L3. The structures of the newly synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR and elemental analysis methods. Next, the cytotoxic activities of the obtained compounds were investigated using human colon cancer cell lines Caco-2, colon and HT-29 colon carcinoma cell lines. The results obtained were compared with the standard chemotherapy drug 5-Fluorouracil 5-FU. According to cytotoxicity results, L2 compound was found to have the highest anticancer activity in Caco-2 column and HT-29 column cell lines.

 In this study, three new Schiff bases were synthesized as a result of the condensation reaction of N-benzyl ethylene diamine and 2-Hydroxy-5-methylbenzaldehyde, 2-Hydroxy-5-methylacetophenone, 2-Hydroxy-5-chloroacetophenone compounds L1, L2 and L3. The structures of the newly synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR and elemental analysis methods. Next, the cytotoxic activities of the obtained compounds were investigated using human colon cancer cell lines Caco-2, colon and HT-29 colon carcinoma cell lines. The results obtained were compared with the standard chemotherapy drug 5-Fluorouracil 5-FU. According to cytotoxicity results, L2 compound was found to have the highest anticancer activity in Caco-2 column and HT-29 column cell lines.

 Bu çalışmada N-benziletilendiamin ile 2-Hidroksi-5-metilbenzaldehit, 2-Hidroksi-5-metilasetofenon, 2-Hidroksi-5-kloroasetofenon bileşiklerinin kondenzasyon reaksiyonu sonucu üç yeni Schiff bazı sentezlendi L1, L2 ve L3. Sentezlenen yeni bileşiklerin yapıları, 1H NMR, 13C NMR, FT-IR ve elemental analiz yöntemleri ile karakterize edildi. Daha sonra, elde edilen bileşiklerin sitotoksik aktiviteleri, insan kolon kanser hücre dizisi Caco-2, kolon ve HT-29 kolon karsinoma hücre dizisi kullanılarak araştırıldı. Elde edilen sonuçlar standart kemoterapi ilacı 5-Fluorourasil 5-FU ile karşılaştırıldı. Sitotoksisite sonuçlarına göre L2 bileşiğinin Caco-2 kolon ve HT-29 kolon hücre hatlarında en yüksek antikanser aktiviteye sahip olduğu bulundu.

Makale detayları

Synthesis and Characterization of New Shiff Bases Containing N-Benzylethylenediamine Unit and Determination of Their Cytotoxic Effects on Human Colon Cancer Cells

Yazarlar:

Fatma Hamurcu

Yayıncı:

Gazi University

Ana Başlıklar:

Biyoinorganik Kimya

Dergi:

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji Vol.11 Issue 3, pp.857-866

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001299415

pISSN:

2147-9526

Schiff base

N-benzylethylenediamine

Anticancer activitySchiff bazı

N-benziletilendiamin

Antikanser aktivite

Sayı

Makale detayları

Synthesis and Characterization of New Shiff Bases Containing N-Benzylethylenediamine Unit and Determination of Their Cytotoxic Effects on Human Colon Cancer Cells

Yazarlar: Fatma Hamurcu

Yayıncı: Gazi University

Ana Başlıklar: Biyoinorganik Kimya

Dergi: Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji Vol.11 Issue 3, pp.857-866

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001299415

pISSN: 2147-9526

Schiff base

N-benzylethylenediamine

Anticancer activitySchiff bazı

N-benziletilendiamin

Antikanser aktivite

Sayı

Yazarlar:

Fatma Hamurcu

Yayıncı:

Gazi University

Ana Başlıklar:

Biyoinorganik Kimya

Dergi:

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji Vol.11 Issue 3, pp.857-866

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001299415

pISSN:

2147-9526