The consequences of aluminium intake on reproductive function in male rats:  a three-generation study

Florin MUSELIN; Romeo Teodor CRISTINA; Violeta IGNA; Eugenia DUMITRESCU; Diana BREZOVAN; Alexandra TRIF

Makale detayları

The consequences of aluminium intake on reproductive function in male rats: a three-generation study

Yazarlar:

Florin MUSELIN | Romeo Teodor CRISTINA | Violeta IGNA | Eugenia DUMITRESCU | Diana BREZOVAN | Alexandra TRIF

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1240-1248

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751999

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The effects of aluminium exposure on reproductive biomarkers in male rats were followed in a three-generation study.  Materials and methods: Forty Wistar male rats (F0) were divided into the following groups: control (C), receiving only tap water, and three experimental (E) groups, receiving aluminium sulphate (AS) (E1: 200 ppb, E2: 400 ppb, and E3: 1000 ppb) in drinking water for a 6-month exposure period. To obtain F1, three males from each group were mated with previously unexposed females (1:2 sex ratios) that during gestation and lactation were exposed to the same AS levels as males. The F1 generation male offspring were divided as described and exposed to the same AS levels. The protocol to obtain F2 was similar to that described for F1.  Results: Significantly lower testosterone levels in rats exposed to AS and in generations F1 and F2 compared to the parental one, luteinising hormone (LH) fluctuations in F0 and a significant LH decrease in F2 and F3 generations, testis weight decrease, increased immobile and abnormal sperm, and histoarchitecture alterations in the testes were observed. Moreover, interval between deliveries increased.  Conclusion: Chronic exposure to AS was significantly deleterious, producing a pronounced decrease in the sperm count and testosterone levels in all experimental groups.

Makale detayları

The consequences of aluminium intake on reproductive function in male rats: a three-generation study

Yazarlar: Florin MUSELIN | Romeo Teodor CRISTINA | Violeta IGNA | Eugenia DUMITRESCU | Diana BREZOVAN | Alexandra TRIF

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1240-1248

Belge Tipi: Makale

Yayın Tarihi: 7/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000751999

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Florin MUSELIN | Romeo Teodor CRISTINA | Violeta IGNA | Eugenia DUMITRESCU | Diana BREZOVAN | Alexandra TRIF

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1240-1248

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751999

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144