Synthesis of N-Mannich bases from 5-((4-methylpiperazin-1-yl)methyl)-1,3,4-oxadiazole-2-thiol

Yıldız Uygun Cebecı

Makale detayları

Synthesis of N-Mannich bases from 5-((4-methylpiperazin-1-yl)methyl)-1,3,4-oxadiazole-2-thiol

Yazarlar:

Yıldız Uygun Cebecı

Yayıncı:

Bitlis Eren University

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.12 Issue 1, pp.146-150

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285746

pISSN:

2147-3129

Anahtar kelimeler:

Özet:

 Methyl 4-methylpiperazin-1-ylacetate 2 were synthesized by the condensation of compound 1 with ethyl bromoacetate in basic media. aThe synthesis of acid hydrazide derivatives 3 was brought about as a result of the reaction between a compound 2 and hydrazine hydrate. In the absence of basic conditions, the reaction of 2-4-methylpiperazin-1-ylacetohydrazide 3 with carbon disulfide resulted in the formation of 5-4-methylpiperazin-1-ylmethyl-1,3,4-oxadiazole-2-thiol 4. aThe reactions of 4 with different primary and secondary amines in the presence of formaldehyde led to the formation of the corresponding Mannich bases 5a-f.

 Methyl 4-methylpiperazin-1-ylacetate 2 were synthesized by the condensation of compound 1 with ethyl bromoacetate in basic media. aThe synthesis of acid hydrazide derivatives 3 was brought about as a result of the reaction between a compound 2 and hydrazine hydrate. In the absence of basic conditions, the reaction of 2-4-methylpiperazin-1-ylacetohydrazide 3 with carbon disulfide resulted in the formation of 5-4-methylpiperazin-1-ylmethyl-1,3,4-oxadiazole-2-thiol 4. aThe reactions of 4 with different primary and secondary amines in the presence of formaldehyde led to the formation of the corresponding Mannich bases 5a-f.

 Methyl 4-methylpiperazin-1-ylacetate 2 were synthesized by the condensation of compound 1 with ethyl bromoacetate in basic media. aThe synthesis of acid hydrazide derivatives 3 was brought about as a result of the reaction between a compound 2 and hydrazine hydrate. In the absence of basic conditions, the reaction of 2-4-methylpiperazin-1-ylacetohydrazide 3 with carbon disulfide resulted in the formation of 5-4-methylpiperazin-1-ylmethyl-1,3,4-oxadiazole-2-thiol 4. aThe reactions of 4 with different primary and secondary amines in the presence of formaldehyde led to the formation of the corresponding Mannich bases 5a-f.

 Methyl 4-methylpiperazin-1-ylacetate 2 were synthesized by the condensation of compound 1 with ethyl bromoacetate in basic media. aThe synthesis of acid hydrazide derivatives 3 was brought about as a result of the reaction between a compound 2 and hydrazine hydrate. In the absence of basic conditions, the reaction of 2-4-methylpiperazin-1-ylacetohydrazide 3 with carbon disulfide resulted in the formation of 5-4-methylpiperazin-1-ylmethyl-1,3,4-oxadiazole-2-thiol 4. aThe reactions of 4 with different primary and secondary amines in the presence of formaldehyde led to the formation of the corresponding Mannich bases 5a-f.

Makale detayları

Yazarlar: Yıldız Uygun Cebecı

Yayıncı: Bitlis Eren University

Dergi: Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.12 Issue 1, pp.146-150

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285746

pISSN: 2147-3129

Sayı

Yazarlar:

Yıldız Uygun Cebecı

Yayıncı:

Bitlis Eren University

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.12 Issue 1, pp.146-150

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285746

pISSN:

2147-3129