Outcomes of fetal non-cardiac thoracic abnormalities: a single center experience

Zeynep Kayaoğlu Yıldırım; Gökhan Bolluk

Makale detayları

Outcomes of fetal non-cardiac thoracic abnormalities: a single center experience

Yazarlar:

Zeynep Kayaoğlu Yıldırım | Gökhan Bolluk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.80-84

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312446

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: This study planned to evaluate fetal non-cardiac thoracic anomalies, which are less common than other organ systems, in terms of diagnosis, incidence, therapy and prognosis. Methods: The data of 66 cases who were evaluated in a perinatology department between January 2021 and July 2023 with diagnosis of fetal non-cardiac thoracic abnormalities were analyzed retrospectively. Results: A total of 66 cases were in our study with a mean maternal age of 28.614.9 years and a median gestational week of first assessment at our center of 24 weeks 15-38 weeks. The most common non-cardiac thoracic malformation was congenital diaphragmatic hernia 30 cases, 45.4, followed by congenital pulmonary airway malformation CPAM 17 cases, 25.7. Termination of pregnancy was performed in 4 cases 6.06. While genetic testing was carried out in a total of 9 cases 13.9, no chromosomal abnormality was found in any of these cases. In utero interventional procedure was performed in 5 cases 7.57 and success was achieved in 3 cases. Ten 58.8 cases with CPAM lesions were resolved during the late antenatal or postnatal period with expectant management. Surgery was performed in 2 11.8 of 17 cases with CPAM. Conclusion: Deliveries of the FNTA cases should be planned in tertiary centers where necessary intervention and care can be provided. A multi-disciplinary team could demonstrate a crucial role in assuring that the pregnant woman and fetus obtain appropriate treatment and are managed during the antenatal and postnatal periods. US plays a crucial role in the diagnosis and management of FNTA cases during the prenatal period rather than fetal MRI and other diagnostic tools. More than half of the CPAM lesions regressed spontaneously with expectant management.

 Aims: This study planned to evaluate fetal non-cardiac thoracic anomalies, which are less common than other organ systems, in terms of diagnosis, incidence, therapy and prognosis. Methods: The data of 66 cases who were evaluated in a perinatology department between January 2021 and July 2023 with diagnosis of fetal non-cardiac thoracic abnormalities were analyzed retrospectively. Results: A total of 66 cases were in our study with a mean maternal age of 28.614.9 years and a median gestational week of first assessment at our center of 24 weeks 15-38 weeks. The most common non-cardiac thoracic malformation was congenital diaphragmatic hernia 30 cases, 45.4, followed by congenital pulmonary airway malformation CPAM 17 cases, 25.7. Termination of pregnancy was performed in 4 cases 6.06. While genetic testing was carried out in a total of 9 cases 13.9, no chromosomal abnormality was found in any of these cases. In utero interventional procedure was performed in 5 cases 7.57 and success was achieved in 3 cases. Ten 58.8 cases with CPAM lesions were resolved during the late antenatal or postnatal period with expectant management. Surgery was performed in 2 11.8 of 17 cases with CPAM. Conclusion: Deliveries of the FNTA cases should be planned in tertiary centers where necessary intervention and care can be provided. A multi-disciplinary team could demonstrate a crucial role in assuring that the pregnant woman and fetus obtain appropriate treatment and are managed during the antenatal and postnatal periods. US plays a crucial role in the diagnosis and management of FNTA cases during the prenatal period rather than fetal MRI and other diagnostic tools. More than half of the CPAM lesions regressed spontaneously with expectant management.

 Aims: This study planned to evaluate fetal non-cardiac thoracic anomalies, which are less common than other organ systems, in terms of diagnosis, incidence, therapy and prognosis. Methods: The data of 66 cases who were evaluated in a perinatology department between January 2021 and July 2023 with diagnosis of fetal non-cardiac thoracic abnormalities were analyzed retrospectively. Results: A total of 66 cases were in our study with a mean maternal age of 28.614.9 years and a median gestational week of first assessment at our center of 24 weeks 15-38 weeks. The most common non-cardiac thoracic malformation was congenital diaphragmatic hernia 30 cases, 45.4, followed by congenital pulmonary airway malformation CPAM 17 cases, 25.7. Termination of pregnancy was performed in 4 cases 6.06. While genetic testing was carried out in a total of 9 cases 13.9, no chromosomal abnormality was found in any of these cases. In utero interventional procedure was performed in 5 cases 7.57 and success was achieved in 3 cases. Ten 58.8 cases with CPAM lesions were resolved during the late antenatal or postnatal period with expectant management. Surgery was performed in 2 11.8 of 17 cases with CPAM. Conclusion: Deliveries of the FNTA cases should be planned in tertiary centers where necessary intervention and care can be provided. A multi-disciplinary team could demonstrate a crucial role in assuring that the pregnant woman and fetus obtain appropriate treatment and are managed during the antenatal and postnatal periods. US plays a crucial role in the diagnosis and management of FNTA cases during the prenatal period rather than fetal MRI and other diagnostic tools. More than half of the CPAM lesions regressed spontaneously with expectant management.

 Amaç Çalışmamızda diğer organ sistemlerine göre daha az görülen fetal kalp dışı toraks anomalilerini tanı, insidans, tedavi ve prognoz açısından değerlendirmeyi planladık. Yöntem Ocak 2021-Temmuz 2023 tarihleri arasında perinatoloji bölümünde fetal kalp dışı torasik anormallik tanısıyla değerlendirilen 66 olgunun verileri retrospektif olarak incelendi. Sonuçlar Çalışmamızda ortalama anne yaşı 28,614,9 ve ortalama gebelik haftası 24,5 en az 15-en çok 38 olan toplam 66 olgu yer aldı. En sık görülen kalp dışı torasik malformasyon konjenital diyafragma hernisi 30 vaka, 45,4 olup bunu konjenital pulmoner hava yolu malformasyonu CPAM 17 vaka, 25,7 ve özofagus atrezisi 6 vaka, 9 takip etti. Olguların 4ünde 6,06 gebelik sonlandırıldı, toplam 9 olguda 13,9 genetik araştırma yapılırken, bu olguların hiçbirinde genetik anormal genetik analize rastlanmadı. Beş olguya 7,57 in utero girişimsel işlem uygulandı ve 3 olguda başarı sağlandı. Çözüm: Diğer organ sistemlerine göre daha az sıklıkta gördüğümüz toraks anomalilerinin görülme sıklığı yıllar içinde pek değişmese de tedavi yaklaşımları ve doğum sonrası prognoz yıllar geçtikçe iyileşmektedir. Yeni tedavi yaklaşımlarından bazılarını kullandık ve iyi sonuçlar aldık.

Makale detayları

Outcomes of fetal non-cardiac thoracic abnormalities: a single center experience

Yazarlar:

Zeynep Kayaoğlu Yıldırım | Gökhan Bolluk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.80-84

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312446

pISSN:

2717-7505

Congenital thoracic malformations

prenatal ultrasound

postnatal treatmentkonjenital torasik malformasyonlar

doğum öncesi ultrason

tedavi

Sayı

Makale detayları

Outcomes of fetal non-cardiac thoracic abnormalities: a single center experience

Yazarlar: Zeynep Kayaoğlu Yıldırım | Gökhan Bolluk

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kadın Hastalıkları ve Doğum

Dergi: Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.80-84

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001312446

pISSN: 2717-7505

Congenital thoracic malformations

prenatal ultrasound

postnatal treatmentkonjenital torasik malformasyonlar

doğum öncesi ultrason

tedavi

Sayı

Yazarlar:

Zeynep Kayaoğlu Yıldırım | Gökhan Bolluk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.80-84

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312446

pISSN:

2717-7505