Comparison of Sirolimus and Colchicine Treatment on the Development of Peritoneal Fibrozis in Rats Having Peritoneal Dialysis

Tamer SAĞIROĞLU; Serhat Oğuz; Mustafa Burak SAYHAN; Mehmet A. YAĞCI; Tülin YALTA; Gönül SAĞIROĞLU; Elif ÇOPUROĞLU

Makale detayları

Comparison of Sirolimus and Colchicine Treatment on the Development of Peritoneal Fibrozis in Rats Having Peritoneal Dialysis

Yazarlar:

Tamer SAĞIROĞLU | Serhat Oğuz | Mustafa Burak SAYHAN | Mehmet A. YAĞCI | Tülin YALTA | Gönül SAĞIROĞLU | Elif ÇOPUROĞLU

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2015 Vol.32 Issue 1, pp.101-106

Belge Tipi:

Makale

Yayın Tarihi:

12/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000759953

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Continuous ambulatory peritoneal dialysis
 is a successful treatment modality for patients with
 end-stage renal disease. Peritoneal fibrosis (PF) is the
 most critical complication of long-term peritoneal dialysis
 (PD).
 Aims: In our study, we aimed to compare the effects of
 colchicine and sirolimus on PF induced by hypertonic
 peritoneal dialysis solutions in rats.
 Study Design: Animal experiment.
 Methods: Twenty-four rats were randomly divided
 into three groups. The control group received an intraperitoneal
 injection (ip) of saline. The sirolimus group
 received the PD solution, plus 1.0 mg/kg/day Rapamune®.
 The colchicine group received the PD solution
 ip plus 1.0 mg/kg/day of colchicine. Blood samples
 were taken to measure the serum levels of VEGF,
 TGF-β, and TNF-α. Peritoneal tissue samples were
 taken for histopathological evaluation.
 Results: TGF-β and TNF-α values in the sirolimus group
 were found to be statistically significantly lower than in
 the control and colchicine groups, but the differences between
 the control and colchicine groups were not statistically
 significant. No statistically significant differences
 were found between the groups regarding the VEGF values.
 Vascular neogenesis and peritoneal thickness were
 compared; the values in the sirolimus group were statistically
 reduced compared to the values in the control group.
 Mild fibrosis developed in 75% of all animals in the sirolimus
 group; there was no moderate or severe fibrosis
 observed. Fibrosis developed to varying degrees in 100%
 of the animals in the control and colchicine groups.
 Conclusion: The present study demonstrates that sirolimus
 might be beneficial for preventing or delaying
 the progression of PF and neoangiogenesis. These alterations
 in the peritoneal membrane may be connected.

Makale detayları

Comparison of Sirolimus and Colchicine Treatment on the Development of Peritoneal Fibrozis in Rats Having Peritoneal Dialysis

Yazarlar: Tamer SAĞIROĞLU | Serhat Oğuz | Mustafa Burak SAYHAN | Mehmet A. YAĞCI | Tülin YALTA | Gönül SAĞIROĞLU | Elif ÇOPUROĞLU

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2015 Vol.32 Issue 1, pp.101-106

Belge Tipi: Makale

Yayın Tarihi: 12/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000759953

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Tamer SAĞIROĞLU | Serhat Oğuz | Mustafa Burak SAYHAN | Mehmet A. YAĞCI | Tülin YALTA | Gönül SAĞIROĞLU | Elif ÇOPUROĞLU

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2015 Vol.32 Issue 1, pp.101-106

Belge Tipi:

Makale

Yayın Tarihi:

12/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000759953

Sıklık:

İki Aylık

pISSN:

2146-3123