Serum Carnosine Dipeptidase 1 and Ubiquitin C - Terminal Hydrolase L1 as Markers of Brain Damage in Patients After Carotid Endarterectomy

Marek ILZECKİ; Joanna ILZECKA; Stanislaw PRZYWARA; Aneta GRABARSKA; Piotr TERLECKİ; Andrzej STEPULAK; Shawn DAVE; Tomasz ZUBİLEWİCZ

doi:https://doi.org/10.5455/umj.20160713014033

Makale detayları

Serum Carnosine Dipeptidase 1 and Ubiquitin C - Terminal Hydrolase L1 as Markers of Brain Damage in Patients After Carotid Endarterectomy

Yazarlar:

Marek ILZECKİ | Joanna ILZECKA | Stanislaw PRZYWARA | Aneta GRABARSKA | Piotr TERLECKİ | Andrzej STEPULAK | Shawn DAVE | Tomasz ZUBİLEWİCZ

Yayıncı:

Kemal Türker ULUTAŞ

Dergi:

The Ulutas Medical Journal 2016 Vol.2 Issue 3, pp.132-137

Belge Tipi:

Makale

Yayın Tarihi:

6/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000802888

Sıklık:

Üç Aylık

eISSN:

2149-388X

pISSN:

2149-0430

DOI:

https://doi.org/10.5455/umj.20160713014033

Özet:

 

Background: Carotid endarterectomy  CEA  is the recommended surgical procedure in the prevention of   ischemic stroke. However, this procedure may lead to vascular neurological complications. The aim of the study   was to measure serum carnosine dipeptidase 1  CNDP1  and ubiquitin C - terminal hydrolase L1  UCHL1 as   markers of brain damagein patients that underwent CEA due to high-grade internal carotid artery stenosis.   Method: This study included in 25 patients. Blood samples were taken from the antecubital vein at three different   intervals  within a 24 h period prior to CEA, 12 h following surgery, and 48 h after surgery . Serum CNDP1 and   UCHL1 levels were measured by a commercially available enzyme-linked immunosorbent assay  ELISA .   Results: The study showed that serum CNDP1 and UCHL1 levels were significantly decreased 12 h after CEA   when compared to level before the surgery. Furthermore, these enzymes levels were normalized 48 h after CEA.   Conclusion: Data from our study showed that CEA significantly affects serum CNDP1 and UCHL1 levels.   Moreover, these enzyme levels seems to reflect a brain ischemia resulting from severe internal carotid artery   stenosis in patients undergoing CEA.

Makale detayları

Serum Carnosine Dipeptidase 1 and Ubiquitin C - Terminal Hydrolase L1 as Markers of Brain Damage in Patients After Carotid Endarterectomy

Yazarlar: Marek ILZECKİ | Joanna ILZECKA | Stanislaw PRZYWARA | Aneta GRABARSKA | Piotr TERLECKİ | Andrzej STEPULAK | Shawn DAVE | Tomasz ZUBİLEWİCZ

Yayıncı: Kemal Türker ULUTAŞ

Dergi: The Ulutas Medical Journal 2016 Vol.2 Issue 3, pp.132-137

Belge Tipi: Makale

Yayın Tarihi: 6/2016

Belge Dili: İngilizce

Document ID (Org No.): 2000802888

Sıklık: Üç Aylık

eISSN: 2149-388X

pISSN: 2149-0430

DOI: https://doi.org/10.5455/umj.20160713014033

Sayı

Yazarlar:

Marek ILZECKİ | Joanna ILZECKA | Stanislaw PRZYWARA | Aneta GRABARSKA | Piotr TERLECKİ | Andrzej STEPULAK | Shawn DAVE | Tomasz ZUBİLEWİCZ

Yayıncı:

Kemal Türker ULUTAŞ

Dergi:

The Ulutas Medical Journal 2016 Vol.2 Issue 3, pp.132-137

Belge Tipi:

Makale

Yayın Tarihi:

6/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000802888

Sıklık:

Üç Aylık

eISSN:

2149-388X

pISSN:

2149-0430

DOI:

https://doi.org/10.5455/umj.20160713014033