Protective effect of edaravone on adriamycin-induced cardiotoxicity in rats

Hatice AYGÜN; Serdar Savaş GÜL

doi:https://doi.org/10.7197/223.vi.531824

Makale detayları

Protective effect of edaravone on adriamycin-induced cardiotoxicity in rats

Yazarlar:

Hatice AYGÜN | Serdar Savaş GÜL

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.10-18

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922591

DOI:

https://doi.org/10.7197/223.vi.531824

Özet:

 


Aim: Adriamycin (ADR) is an antineoplastic drug that
is widely used in chemotherapy but its cardiotoxicity is the most important
side effect that limits the clinical use of this drug. In this study, we
investigated of edaravone (EDO), which is a potent antioxidant, ADR-induced
cardiotoxicity model in rats by electrocardiographic (ECG), biochemical and
scintigraphic methods.


Methods: Twenty-eight adult male
Wistar-Albino rats were randomly separated into four groups; namely control
(CON); Adriamycin (ADR); substance control of edaravone (EDO), edaravone +
adriamycin (EDO+ADR) groups. Cardiotoxicity in rats was induced by adriamycin
injection (cumulative dose:18 mg/kg, intraperitoneal-i.p.-) at an interval of
24 hours (h) on the 5th, 6th and 7th days.
Rats receiving edaravone treatment in the adriamycin group administration
edaravone (30 mg/kg/day, i.p.) for 7 days and were injected with adriamycin (18
mg/kg, i.p.) on 5th, 6th and 7th days.
On the 8th day electrocardiography (ECG), biochemical and
technetium-99m pyrophosphate (99mTc-PYP) scintigraphic parameters
were assessed.


 Results: ADR
induction caused changes in the ECG pattern, decreased heartbeat, P wave and
QRS complex duration,  increased both ST-segment amplitude and QT interval
duration (p < 0,001), increase in the biochemical markers [blood urea
nitrogen (BUN), creatine kinase (CK), cardiac troponin T (cTnT)], and
 elevated 99mTc-PYP uptake level (p < 0,001). EDO
treatment prevented all the parameters of ADR-induced cardiotoxicity in rats,
by significantly decreased all ADR-associated conduction abnormalities in
ECG (p < 0.001), decreased 99mTc-PYP uptake (p <
0.001) and serum BUN, CK and cTnT, (p < 0.001).









Conclusions: Our data demonstrate
that EDO has cardioprotective effects on DOX-induced cardiotoxicity. At the
same time, this study suggested that 99mTc-PYP may be using as
a non-invasive method for the early diagnosis of ADR-induced cardiotoxicity.


.

Makale detayları

Protective effect of edaravone on adriamycin-induced cardiotoxicity in rats

Yazarlar: Hatice AYGÜN | Serdar Savaş GÜL

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.10-18

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000922591

DOI: https://doi.org/10.7197/223.vi.531824

Sayı

Yazarlar:

Hatice AYGÜN | Serdar Savaş GÜL

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2019 Vol.41 Issue 1, pp.10-18

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000922591

DOI:

https://doi.org/10.7197/223.vi.531824