AN EVALUATION OF THE AST/ALT RATIO IN PATIENTS WITH MYCOSIS FUNGOIDES AND ITS ASSOCIATION WITH THE SEVERITY OF CUTANEOUS INVOLVEMENT

Erdal Pala; Mustafa Bayraktar

Makale detayları

AN EVALUATION OF THE AST/ALT RATIO IN PATIENTS WITH MYCOSIS FUNGOIDES AND ITS ASSOCIATION WITH THE SEVERITY OF CUTANEOUS INVOLVEMENT

Yazarlar:

Erdal Pala | Mustafa Bayraktar

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.53-59

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341395

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: Mycosis fungoides MF is the most common T-cell skin lymphoma, and a simple and applicable parameter is need ed to monitor the prognosis of the disease. We investigated the ratio of aspartate aminotransferase AST and alanine amino transferase ALT in patients with MF. Material and Methods: The research involved a retrospective, cross-sectional study. The records of MF patients were analysed. AST and ALT levels were recorded and the ASTALT ratio was calculated and compared with the control group. Results: Eighty-five MF patients and 85 healthy controls were included in the study. Males accounted for 56.5 n48 of MF patients and 57.6  n49 of healthy group, with no sig nificant difference p0.05 between them. AST levels were notably elevated in the MF group compared with the healthy group p0.001. Furthermore, there was a significant differ ence in the ASTALT ratio between the two groups p0.005. The ASTALT ratio cut-off value was 1.067. The AST value in the patients with abnormal lymphadenopathy LAP on ultra sonography USG was higher than in those with reactive LAP. The AST values of the patients with LAP with fluorodeoxyglu cose FDG involvement on positron emission tomography PETcomputed tomography CT were significantly higher than those of the patients without abnormal LAPs p0.05. The ASTALT ratio was weakly positively correlated with the disease stage p0.018. Conclusion: AST values and ASTALT ratios of patients with MF were significantly higher than those of the control group. The ASTALT ratio can be used as an independent factor in monitor ing the prognosis of patients with MF.

 Objective: Mycosis fungoides MF is the most common T-cell skin lymphoma, and a simple and applicable parameter is need ed to monitor the prognosis of the disease. We investigated the ratio of aspartate aminotransferase AST and alanine amino transferase ALT in patients with MF. Material and Methods: The research involved a retrospective, cross-sectional study. The records of MF patients were analysed. AST and ALT levels were recorded and the ASTALT ratio was calculated and compared with the control group. Results: Eighty-five MF patients and 85 healthy controls were included in the study. Males accounted for 56.5 n48 of MF patients and 57.6  n49 of healthy group, with no sig nificant difference p0.05 between them. AST levels were notably elevated in the MF group compared with the healthy group p0.001. Furthermore, there was a significant differ ence in the ASTALT ratio between the two groups p0.005. The ASTALT ratio cut-off value was 1.067. The AST value in the patients with abnormal lymphadenopathy LAP on ultra sonography USG was higher than in those with reactive LAP. The AST values of the patients with LAP with fluorodeoxyglu cose FDG involvement on positron emission tomography PETcomputed tomography CT were significantly higher than those of the patients without abnormal LAPs p0.05. The ASTALT ratio was weakly positively correlated with the disease stage p0.018. Conclusion: AST values and ASTALT ratios of patients with MF were significantly higher than those of the control group. The ASTALT ratio can be used as an independent factor in monitor ing the prognosis of patients with MF.

 Objective: Mycosis fungoides MF is the most common T-cell skin lymphoma, and a simple and applicable parameter is need ed to monitor the prognosis of the disease. We investigated the ratio of aspartate aminotransferase AST and alanine amino transferase ALT in patients with MF. Material and Methods: The research involved a retrospective, cross-sectional study. The records of MF patients were analysed. AST and ALT levels were recorded and the ASTALT ratio was calculated and compared with the control group. Results: Eighty-five MF patients and 85 healthy controls were included in the study. Males accounted for 56.5 n48 of MF patients and 57.6  n49 of healthy group, with no sig nificant difference p0.05 between them. AST levels were notably elevated in the MF group compared with the healthy group p0.001. Furthermore, there was a significant differ ence in the ASTALT ratio between the two groups p0.005. The ASTALT ratio cut-off value was 1.067. The AST value in the patients with abnormal lymphadenopathy LAP on ultra sonography USG was higher than in those with reactive LAP. The AST values of the patients with LAP with fluorodeoxyglu cose FDG involvement on positron emission tomography PETcomputed tomography CT were significantly higher than those of the patients without abnormal LAPs p0.05. The ASTALT ratio was weakly positively correlated with the disease stage p0.018. Conclusion: AST values and ASTALT ratios of patients with MF were significantly higher than those of the control group. The ASTALT ratio can be used as an independent factor in monitor ing the prognosis of patients with MF.

 Amaç: Mikozis fungoides MF, derinin en sık görülen T hücreli lenfoması olup hastalığın prognozunu takip etmede kullanışlı, basit parametrelere ihtiyaç duyulmaktadır. Çalışmamızda son za manlarda birçok malignitede prognostik faktör olarak araştırılan aspartat aminotransaminaz AST ve alanin aminotransaminaz ALT oranının bir deri lenfoması olan MFde değerlendirilmesini amaçladık. Gereç ve Yöntem: Çalışmamız retrospektif kesitsel bir çalışma dır. Çalışmada MF tanısı alan hastaların dosya taraması yapıldı. AST, ALT değerleri kaydedilerek ASTALT oranı hesaplanıp, kontrol grubu ile istatistiksel olarak karşılaştırıldı. Bulgular: Çalışmaya 85 MF hastası ve 85 sağlıklı kontrol olmak üzere toplam 170 kişi dahil edildi. Buna göre, MF grubunun 56,5i n48 ve sağlıklı kontrol grubunun 57.6 n49sı erkek idi ve gruplar arası anlamlı farklılık bulunmuyordu p0,05. MF grubunun AST değeri sağlıklı gruba göre daha yüksekti ve istatistiksel anlamlı farklılık saptandı p0,001. ASTALT oranı her iki grup arasında istatistiksel olarak anlam lı farklılık saptandı p0,005. ASTALT oranı cut-off değeri ise 1,067 bulunmuştur. USGde anormal LAP saptanan hastalarda AST değeri reaktif LAP olanlara göre daha yüksek bulundu. PET CTde ise, FDG tutulumu olan LAPları saptanan hastaların AST değeri, anormal LAPları olmayan hastalardan anlamlı yüksek olarak saptandı p0,05. ASTALT oranı ise hastalık evresi ile zayıf pozitif korele bulundu p0,018. Sonuç: Çalışmamızın sonucunda, MFli hastaların AST değeri ve ASTALT oranı sağlıklı kontrol grubuna göre istatistiksel olarak anlamlı yüksek bulunmuştur. MF hastalarının prognozunun taki binde ASTALT oranı bağımsız bir faktör olarak kullanılabilir.

Makale detayları

AN EVALUATION OF THE AST/ALT RATIO IN PATIENTS WITH MYCOSIS FUNGOIDES AND ITS ASSOCIATION WITH THE SEVERITY OF CUTANEOUS INVOLVEMENT

Yazarlar:

Erdal Pala | Mustafa Bayraktar

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.53-59

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341395

pISSN:

1305-6441

Mycosis fungoides

aspartate aminotransferase (AST)

alanine aminotransferase (ALT)

AST/ALT ratio

prog nostic factorMikozis fungoides

aspartat aminotransfe raz (AST)

alanin aminoaminotransferaz (ALT)

AST/ALT oranı

prognostik faktör

Sayı

Makale detayları

Yazarlar: Erdal Pala | Mustafa Bayraktar

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.53-59

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341395

pISSN: 1305-6441

Sayı

Yazarlar:

Erdal Pala | Mustafa Bayraktar

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.88 Issue 1, pp.53-59

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341395

pISSN:

1305-6441