Cerimetric Determination of Propranolol in Bulk Drug Form and in Tablets

Kanakapura BASAVAIAH; Umakanthappa CHANDRASHEKAR

Makale detayları

Cerimetric Determination of Propranolol in Bulk Drug Form and in Tablets

Yazarlar:

Kanakapura BASAVAIAH | Umakanthappa CHANDRASHEKAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2003 Vol.27 Issue 5, pp.591-600

Belge Tipi:

Makale

Yayın Tarihi:

4/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000729498

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Two simple, accurate and precise methods are described for  the determination of propranolol hydrochloride with cerium(IV)  sulphate.  The titrimetric method is based on the oxidation of the  drug by a known excess amount of cerium(IV) sulphate and back  titration of the unconsumed oxidant with ammonium ferrous sulphate.   In the spectrophotometric method, the unreacted cerium(IV) sulphate is  treated with iron(II) sulphate, and the iron(III) sulphate produced is  complexed with thiocyanate and measured at 480 nm, thereby permitting  the determination of the amount of unreacted cerium(IV) sulphate.  In  both procedures, the amount of the reacted oxidant corresponds to the  drug content.  Different variables affecting the reaction between  propranolol and cerium(IV) sulphate were studied and optimised.  In  titrimetry, the reaction stoichiometry which formed the basis for  calculations was established.  At 480 nm, Beer's law is obeyed for 0-5  m g mL-1 of propranolol hydrochloride.  The molar absorptivity  and Sandell sensitivity of the procedure were calculated in addition  to limits of detection and quantification.  Excipients used as  additives in pharmaceutical formulations did not interfere in the  proposed procedures.  The procedures described were successfully  applied to the determination of propranolol hydrochloride in bulk drug  form and in tablets.

 

Two simple, accurate and precise methods are described for  the determination of propranolol hydrochloride with cerium(IV)  sulphate.  The titrimetric method is based on the oxidation of the  drug by a known excess amount of cerium(IV) sulphate and back  titration of the unconsumed oxidant with ammonium ferrous sulphate.   In the spectrophotometric method, the unreacted cerium(IV) sulphate is  treated with iron(II) sulphate, and the iron(III) sulphate produced is  complexed with thiocyanate and measured at 480 nm, thereby permitting  the determination of the amount of unreacted cerium(IV) sulphate.  In  both procedures, the amount of the reacted oxidant corresponds to the  drug content.  Different variables affecting the reaction between  propranolol and cerium(IV) sulphate were studied and optimised.  In  titrimetry, the reaction stoichiometry which formed the basis for  calculations was established.  At 480 nm, Beer's law is obeyed for 0-5  m g mL-1 of propranolol hydrochloride.  The molar absorptivity  and Sandell sensitivity of the procedure were calculated in addition  to limits of detection and quantification.  Excipients used as  additives in pharmaceutical formulations did not interfere in the  proposed procedures.  The procedures described were successfully  applied to the determination of propranolol hydrochloride in bulk drug  form and in tablets.

Makale detayları

Cerimetric Determination of Propranolol in Bulk Drug Form and in Tablets

Yazarlar: Kanakapura BASAVAIAH | Umakanthappa CHANDRASHEKAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2003 Vol.27 Issue 5, pp.591-600

Belge Tipi: Makale

Yayın Tarihi: 4/2003

Belge Dili: Türkçe

Document ID (Org No.): 2000729498

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Kanakapura BASAVAIAH | Umakanthappa CHANDRASHEKAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2003 Vol.27 Issue 5, pp.591-600

Belge Tipi:

Makale

Yayın Tarihi:

4/2003

Belge Dili:

Türkçe

Document ID (Org No.):

2000729498

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527