Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients

İşil Köse GÜLDOĞAN; Çiler ZİNCİRCİOĞLU; Hüseyin ÖZKARAKAŞ; Meltem ÇAKMAK; Gürsel ERSAN; Lütfiye KUZUCU; Şükran KÖSE; Nimet ŞENOĞLU

Makale detayları

Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients

Yazarlar:

İşil Köse GÜLDOĞAN | Çiler ZİNCİRCİOĞLU | Hüseyin ÖZKARAKAŞ | Meltem ÇAKMAK | Gürsel ERSAN | Lütfiye KUZUCU | Şükran KÖSE | Nimet ŞENOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.324-331

Belge Tipi:

Makale

Yayın Tarihi:

3/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750820

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D de ciency and  nosocomial infections among intensive care unit (ICU) patients.  Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbid conditions, and admission diagnosis were recorded in 306 ICU patients. Infections that developed at least 48 h a er admission to the ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes. Infections were evaluated for 28 days, and for the entire duration of ICU stay independently. Multiple logistic regression analysis was performed to control for confounding factors that were statistically signi cant in univariate analysis.  Results: All infection and mortality rates were signi cantly higher in low 25 (OH) D groups in univariate analysis. A er adjusting for confounding factors, infection rates remained higher in the de cient group. However, ICU and hospital mortality did not show any statistically signi cant di erence between de cient and nonde cient groups. Only the 1-year mortality rate was signi cantly higher among patients with 25 (OH) D levels less than 20 ng/mL.  Conclusion: Low vitamin D levels are signi cantly associated with ICU-related infections but not with ICU or hospital mortality. However, further studies are needed to identify the role of vitamin D de ciency in predicting ICU outcomes.

Makale detayları

Low levels of vitamin D are associated with nosocomial infections but not with short-term mortality in critically ill patients

Yazarlar: İşil Köse GÜLDOĞAN | Çiler ZİNCİRCİOĞLU | Hüseyin ÖZKARAKAŞ | Meltem ÇAKMAK | Gürsel ERSAN | Lütfiye KUZUCU | Şükran KÖSE | Nimet ŞENOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.324-331

Belge Tipi: Makale

Yayın Tarihi: 3/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750820

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

İşil Köse GÜLDOĞAN | Çiler ZİNCİRCİOĞLU | Hüseyin ÖZKARAKAŞ | Meltem ÇAKMAK | Gürsel ERSAN | Lütfiye KUZUCU | Şükran KÖSE | Nimet ŞENOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.324-331

Belge Tipi:

Makale

Yayın Tarihi:

3/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750820

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144