Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Nazmiye Semiz; Mehmet Zeki Yılmaz Deveci

Makale detayları

Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Yazarlar:

Nazmiye Semiz | Mehmet Zeki Yılmaz Deveci

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.71 Issue 4, pp.487-496

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325149

pISSN:

1300-0861

Anahtar kelimeler:

Özet:

 The aim of this study was to investigate the effects of common centaury Centaurium erythraea oil and laurel Laurus nobilis seed oil in a full-thickness excisional skin wound model in rats. In the present study, 18 adult male Wistar rats were divided into three groups n6 the control CO group, the common centaury oil CCO group, and the laurel seed oil LSO group. Under general anesthesia, a full-thickness excisional wound 2.25 cm² was created on the caudal of the interscapular region on the back of the rats. Treatments were applied topically once a day in all groups. Wound area measurements revealed that the use of CCO accelerated wound healing, while the use of LSO disturbed the healing process P0.001. In the histopathological results, blood vessel formation, fiber synthesis, granulation, and mononuclear cells in the wounds were higher in the CCO group than the other groups and higher in the LSO group than the CO group. Biochemical results revealed differences between groups in TP, GLU, and UREA values P0.05. As a result, it was determined that the topical use of common centaury oil accelerated wound healing, while laurel seed oil adversely affected wound healing in the experimental excisional full-thickness skin wound model in rats.

 The aim of this study was to investigate the effects of common centaury Centaurium erythraea oil and laurel Laurus nobilis seed oil in a full-thickness excisional skin wound model in rats. In the present study, 18 adult male Wistar rats were divided into three groups n6 the control CO group, the common centaury oil CCO group, and the laurel seed oil LSO group. Under general anesthesia, a full-thickness excisional wound 2.25 cm² was created on the caudal of the interscapular region on the back of the rats. Treatments were applied topically once a day in all groups. Wound area measurements revealed that the use of CCO accelerated wound healing, while the use of LSO disturbed the healing process P0.001. In the histopathological results, blood vessel formation, fiber synthesis, granulation, and mononuclear cells in the wounds were higher in the CCO group than the other groups and higher in the LSO group than the CO group. Biochemical results revealed differences between groups in TP, GLU, and UREA values P0.05. As a result, it was determined that the topical use of common centaury oil accelerated wound healing, while laurel seed oil adversely affected wound healing in the experimental excisional full-thickness skin wound model in rats.

 The aim of this study was to investigate the effects of common centaury Centaurium erythraea oil and laurel Laurus nobilis seed oil in a full-thickness excisional skin wound model in rats. In the present study, 18 adult male Wistar rats were divided into three groups n6 the control CO group, the common centaury oil CCO group, and the laurel seed oil LSO group. Under general anesthesia, a full-thickness excisional wound 2.25 cm² was created on the caudal of the interscapular region on the back of the rats. Treatments were applied topically once a day in all groups. Wound area measurements revealed that the use of CCO accelerated wound healing, while the use of LSO disturbed the healing process P0.001. In the histopathological results, blood vessel formation, fiber synthesis, granulation, and mononuclear cells in the wounds were higher in the CCO group than the other groups and higher in the LSO group than the CO group. Biochemical results revealed differences between groups in TP, GLU, and UREA values P0.05. As a result, it was determined that the topical use of common centaury oil accelerated wound healing, while laurel seed oil adversely affected wound healing in the experimental excisional full-thickness skin wound model in rats.

 Çalışmanın amacı, kırmızı kantaron Centaurium erythraea yağı ve defne Laurus nobilis tohumu yağının ratlarda tam kalınlıklı eksizyonel deri yara modelinde etkilerinin araştırılmasıdır. Çalışmada kullanılan 18 adet erişkin, erkek Wistar rat; kontrol CO, kırmızı kantarın yağı CCO ve defne tohumu yağı LSO olmak üzere üç gruba n6 ayırıldı. Genel anestezi altında her bir ratın sırtında interskapular bölgenin kaudalinde tam kalınlıklı eksizyonel yara 2.25 cm2 oluşturuldu. Tedaviler tüm gruplarda günde bir kez topikal olarak uygulandı. Yara alanı ölçümleri CCOnun yara iyileşmesini hızlandırdığını, LSOnun ise yara iyileşmesini geciktirdiğini gösterdi. Histopatolojik sonuçlarda kan damarları oluşumu, fiber sentezi, granülasyon ve mononükleer hücreler CCO grubundaki yara dokularında diğer gruplardan daha yüksek, LSOda ise CO grubundan daha yüksek bulundu. Biyokimyasal sonuçlar gruplar arasında TP, GLU ve UREA değerlerinde anlamlı farklılıklar gösterdi p  0.05. Sonuç olarak, bu çalışma, ratlarda deneysel tam kalınlıklı eksizyonel deri yara modelinde kırmızı kantaron yağının topikal kullanımının yara iyileşmesini hızlandırdığını, defne tohumu yağının ise yara iyileşmesini olumsuz etkilediğini ortaya koymaktadır.

Makale detayları

Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Yazarlar:

Nazmiye Semiz | Mehmet Zeki Yılmaz Deveci

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.71 Issue 4, pp.487-496

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325149

pISSN:

1300-0861

Alternative

centaurium

dermatology

experimental

herbal oil

in vivoAlternatif

bitkisel yağ

deneysel

dermatoloji

in vivo

kantaron

Sayı

Makale detayları

Yazarlar: Nazmiye Semiz | Mehmet Zeki Yılmaz Deveci

Yayıncı: Ankara University

Ana Başlıklar: Veterinary Surgery

Dergi: Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.71 Issue 4, pp.487-496

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001325149

pISSN: 1300-0861

Sayı

Yazarlar:

Nazmiye Semiz | Mehmet Zeki Yılmaz Deveci

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.71 Issue 4, pp.487-496

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001325149

pISSN:

1300-0861