Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm

N.A.

Makale detayları

Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 5, pp.632-639

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347989

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In this study, we used methanolic extract of Morinda citrifolia Linn. fruit MMC in order to find its effect against ethanol seeking behavior in a modified mouse runway paradigm. During conditioningacquisition animals were treated with accelerated doses of ethanol 0.5-4 gkg, i.p. for 5 days Day 1- Day 5. Then, ethanol seeking behavior was assessed on Day 6 postconditioning test. Ethanol seeking behavior was confirmed in ethanol control group in which the run time to reach the target box was significantly decreased. The test drug MMC 1, 3, and 5 gkg, p.o. caused a significant reversal of the ethanol seeking behavior by increasing the run time to reach the goal box as seen with the reference drug acamprosate ACAM; 300 mgkg, p.o. in mice. After postconditioning test, nonrewarded abolishment assays were performed for a period of five days Day 7 Day 11. After 5 days of abolishment abstinence, a priming dose of ethanol the highest dose at 15th portion applied in control i.e. 0.8 gkg, i.p. in house cage significantly reinstated the ethanol-seeking behavior. Interestingly, MMC at a higher dose 5 gkg, p.o. showed significant halt on ethanol-induced reinstatement in mice as shown with the reference drug ACAM 300 mgkg, p.o.. The outcome of this study reveals that MMC alleviated ethanol seeking behaviour in modified mouse runway paradigm and it could be effectively used to treat alcohol dependence.

 In this study, we used methanolic extract of Morinda citrifolia Linn. fruit MMC in order to find its effect against ethanol seeking behavior in a modified mouse runway paradigm. During conditioningacquisition animals were treated with accelerated doses of ethanol 0.5-4 gkg, i.p. for 5 days Day 1- Day 5. Then, ethanol seeking behavior was assessed on Day 6 postconditioning test. Ethanol seeking behavior was confirmed in ethanol control group in which the run time to reach the target box was significantly decreased. The test drug MMC 1, 3, and 5 gkg, p.o. caused a significant reversal of the ethanol seeking behavior by increasing the run time to reach the goal box as seen with the reference drug acamprosate ACAM; 300 mgkg, p.o. in mice. After postconditioning test, nonrewarded abolishment assays were performed for a period of five days Day 7 Day 11. After 5 days of abolishment abstinence, a priming dose of ethanol the highest dose at 15th portion applied in control i.e. 0.8 gkg, i.p. in house cage significantly reinstated the ethanol-seeking behavior. Interestingly, MMC at a higher dose 5 gkg, p.o. showed significant halt on ethanol-induced reinstatement in mice as shown with the reference drug ACAM 300 mgkg, p.o.. The outcome of this study reveals that MMC alleviated ethanol seeking behaviour in modified mouse runway paradigm and it could be effectively used to treat alcohol dependence.

 In this study, we used methanolic extract of Morinda citrifolia Linn. fruit MMC in order to find its effect against ethanol seeking behavior in a modified mouse runway paradigm. During conditioningacquisition animals were treated with accelerated doses of ethanol 0.5-4 gkg, i.p. for 5 days Day 1- Day 5. Then, ethanol seeking behavior was assessed on Day 6 postconditioning test. Ethanol seeking behavior was confirmed in ethanol control group in which the run time to reach the target box was significantly decreased. The test drug MMC 1, 3, and 5 gkg, p.o. caused a significant reversal of the ethanol seeking behavior by increasing the run time to reach the goal box as seen with the reference drug acamprosate ACAM; 300 mgkg, p.o. in mice. After postconditioning test, nonrewarded abolishment assays were performed for a period of five days Day 7 Day 11. After 5 days of abolishment abstinence, a priming dose of ethanol the highest dose at 15th portion applied in control i.e. 0.8 gkg, i.p. in house cage significantly reinstated the ethanol-seeking behavior. Interestingly, MMC at a higher dose 5 gkg, p.o. showed significant halt on ethanol-induced reinstatement in mice as shown with the reference drug ACAM 300 mgkg, p.o.. The outcome of this study reveals that MMC alleviated ethanol seeking behaviour in modified mouse runway paradigm and it could be effectively used to treat alcohol dependence.

 In this study, we used methanolic extract of Morinda citrifolia Linn. fruit MMC in order to find its effect against ethanol seeking behavior in a modified mouse runway paradigm. During conditioningacquisition animals were treated with accelerated doses of ethanol 0.5-4 gkg, i.p. for 5 days Day 1- Day 5. Then, ethanol seeking behavior was assessed on Day 6 postconditioning test. Ethanol seeking behavior was confirmed in ethanol control group in which the run time to reach the target box was significantly decreased. The test drug MMC 1, 3, and 5 gkg, p.o. caused a significant reversal of the ethanol seeking behavior by increasing the run time to reach the goal box as seen with the reference drug acamprosate ACAM; 300 mgkg, p.o. in mice. After postconditioning test, nonrewarded abolishment assays were performed for a period of five days Day 7 Day 11. After 5 days of abolishment abstinence, a priming dose of ethanol the highest dose at 15th portion applied in control i.e. 0.8 gkg, i.p. in house cage significantly reinstated the ethanol-seeking behavior. Interestingly, MMC at a higher dose 5 gkg, p.o. showed significant halt on ethanol-induced reinstatement in mice as shown with the reference drug ACAM 300 mgkg, p.o.. The outcome of this study reveals that MMC alleviated ethanol seeking behaviour in modified mouse runway paradigm and it could be effectively used to treat alcohol dependence.

Makale detayları

Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 5, pp.632-639

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347989

pISSN:

2630-6344

Alcohol dependence

acamprosate

Morinda citrifolia Linn

mouse runway paradigm

selfadministration

Sayı

Makale detayları

Morinda citrifolia Linn. (Noni) fruit extract attenuates ethanol seeking behavior in mouse runway paradigm

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 5, pp.632-639

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347989

pISSN: 2630-6344

Alcohol dependence

acamprosate

Morinda citrifolia Linn

mouse runway paradigm

selfadministration

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 5, pp.632-639

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347989

pISSN:

2630-6344