Adults with common variable immunodeficiency: a singlecenter experience

Uğur Haci MUŞABAK; Fevzi DEMİREL; Sait YEŞİLLİK; Abdullah BAYSAN; Ali SELÇUK; Özgür KARTAL; Mustafa GÜLEÇ; Çağatay ÖKTENLİ; Osman ŞENER

Makale detayları

Adults with common variable immunodeficiency: a singlecenter experience

Yazarlar:

Uğur Haci MUŞABAK | Fevzi DEMİREL | Sait YEŞİLLİK | Abdullah BAYSAN | Ali SELÇUK | Özgür KARTAL | Mustafa GÜLEÇ | Çağatay ÖKTENLİ | Osman ŞENER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751510

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: In this study, we aimed to assess the clinical and immunological findings of our patients with common variable immunodeficiency (CVID).   Materials and methods: We analyzed the records of 31 adult patients with CVID (12 females, 19 males). The patients were classified into clinical and immunophenotypic subgroups for statistical comparisons.   Results: Our patients had some clinical signs in considerable frequencies, such as low body weight (45.2%), urinary tract infections (41.9%), various dermatoses (35.5%), and oral aphthae (32.3%). The histological findings in the biopsy specimens of the gastrointestinal tract (nodular lymphoid hyperplasia, villous atrophy, and lymphocytic infiltrates at mucosa) were significantly associated with splenomegaly, hepatomegaly, or low body weight (P = 0.005, 0.045, and 0.007, respectively). The patients with low CD4/CD8 ratios had lower IgG levels and a lower percentage of CD19+ B cells, but a higher percentage of activated T cells (P = 0.023, 0.011, and 0.028, respectively).   Conclusion: In adults with CVID, there existed some clinical signs at considerable frequencies, but these are not overemphasized in the literature. The CD4/CD8 ratio is an important factor in antibody production and the clinical presentation of CVID. It seems that the adaptive immune system is on alert and subclinical immune activation insidiously continues in patients with CVID.

Makale detayları

Adults with common variable immunodeficiency: a singlecenter experience

Yazarlar: Uğur Haci MUŞABAK | Fevzi DEMİREL | Sait YEŞİLLİK | Abdullah BAYSAN | Ali SELÇUK | Özgür KARTAL | Mustafa GÜLEÇ | Çağatay ÖKTENLİ | Osman ŞENER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.1-12

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751510

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Uğur Haci MUŞABAK | Fevzi DEMİREL | Sait YEŞİLLİK | Abdullah BAYSAN | Ali SELÇUK | Özgür KARTAL | Mustafa GÜLEÇ | Çağatay ÖKTENLİ | Osman ŞENER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.1-12

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751510

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144