The relationship between systemic immune-inflammation indexes and treatment response in locally advanced esophageal cancer

Esra Kekilli; Ebru Atasever Akkaş; Serab Uyar; Emre Yekedüz

Makale detayları

The relationship between systemic immune-inflammation indexes and treatment response in locally advanced esophageal cancer

Yazarlar:

Esra Kekilli | Ebru Atasever Akkaş | Serab Uyar | Emre Yekedüz

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 1, pp.53-58

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282647

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aim: Systemic immune-inflammation indexes have been reported to be associated with clinical outcomes in several malignancies. Herein, we aimed to evaluate the potential relationship between prognostic nutritional index PNI, systemic immune-inflammation index SII, the neutrophil- to- lymphocyte ratio NLR, the monocyte- to- lymphocyte ratio MLR, the platelet-to-lymphocyte ratio PLR and the treatment response in patients with esophageal cancer who underwent neoadjuvant chemoradiotherapy CRT. Material and Method: Esophageal cancer EC patients who underwent neoadjuvant CRT were retrospectively enrolled in the study. Immune-inflammation indexes were calculated from pretreatment blood counts in samples obtained. The relationships between PNI, SII, NLR, MLR, PLR values, treatment response, and overall survival OS rates were examined. Results: The data of 103 patients with EC who were referred to the Radiation Oncology Clinic of Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were retrospectively analyzed. In the univariate analysis for OS, alcohol consumption, CRT agent, NLR, MLR, PLR, SII and PNI were found as prognostic factors. Also alcohol consumption was found as an independent prognostic factor in multivariate analyzes HR:5.201, 95 CI:1.9-14.2, p0.01. Conclusion: In our study, high SII and low PNI values were not found to be independent poor prognostic factors for OS, but lower OS rates were observed in patients with high SII and low PNI values.

 Aim: Systemic immune-inflammation indexes have been reported to be associated with clinical outcomes in several malignancies. Herein, we aimed to evaluate the potential relationship between prognostic nutritional index PNI, systemic immune-inflammation index SII, the neutrophil- to- lymphocyte ratio NLR, the monocyte- to- lymphocyte ratio MLR, the platelet-to-lymphocyte ratio PLR and the treatment response in patients with esophageal cancer who underwent neoadjuvant chemoradiotherapy CRT. Material and Method: Esophageal cancer EC patients who underwent neoadjuvant CRT were retrospectively enrolled in the study. Immune-inflammation indexes were calculated from pretreatment blood counts in samples obtained. The relationships between PNI, SII, NLR, MLR, PLR values, treatment response, and overall survival OS rates were examined. Results: The data of 103 patients with EC who were referred to the Radiation Oncology Clinic of Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were retrospectively analyzed. In the univariate analysis for OS, alcohol consumption, CRT agent, NLR, MLR, PLR, SII and PNI were found as prognostic factors. Also alcohol consumption was found as an independent prognostic factor in multivariate analyzes HR:5.201, 95 CI:1.9-14.2, p0.01. Conclusion: In our study, high SII and low PNI values were not found to be independent poor prognostic factors for OS, but lower OS rates were observed in patients with high SII and low PNI values.

 Aim: Systemic immune-inflammation indexes have been reported to be associated with clinical outcomes in several malignancies. Herein, we aimed to evaluate the potential relationship between prognostic nutritional index PNI, systemic immune-inflammation index SII, the neutrophil- to- lymphocyte ratio NLR, the monocyte- to- lymphocyte ratio MLR, the platelet-to-lymphocyte ratio PLR and the treatment response in patients with esophageal cancer who underwent neoadjuvant chemoradiotherapy CRT. Material and Method: Esophageal cancer EC patients who underwent neoadjuvant CRT were retrospectively enrolled in the study. Immune-inflammation indexes were calculated from pretreatment blood counts in samples obtained. The relationships between PNI, SII, NLR, MLR, PLR values, treatment response, and overall survival OS rates were examined. Results: The data of 103 patients with EC who were referred to the Radiation Oncology Clinic of Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were retrospectively analyzed. In the univariate analysis for OS, alcohol consumption, CRT agent, NLR, MLR, PLR, SII and PNI were found as prognostic factors. Also alcohol consumption was found as an independent prognostic factor in multivariate analyzes HR:5.201, 95 CI:1.9-14.2, p0.01. Conclusion: In our study, high SII and low PNI values were not found to be independent poor prognostic factors for OS, but lower OS rates were observed in patients with high SII and low PNI values.

 Aim: Systemic immune-inflammation indexes have been reported to be associated with clinical outcomes in several malignancies. Herein, we aimed to evaluate the potential relationship between prognostic nutritional index PNI, systemic immune-inflammation index SII, the neutrophil- to- lymphocyte ratio NLR, the monocyte- to- lymphocyte ratio MLR, the platelet-to-lymphocyte ratio PLR and the treatment response in patients with esophageal cancer who underwent neoadjuvant chemoradiotherapy CRT. Material and Method: Esophageal cancer EC patients who underwent neoadjuvant CRT were retrospectively enrolled in the study. Immune-inflammation indexes were calculated from pretreatment blood counts in samples obtained. The relationships between PNI, SII, NLR, MLR, PLR values, treatment response, and overall survival OS rates were examined. Results: The data of 103 patients with EC who were referred to the Radiation Oncology Clinic of Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were retrospectively analyzed. In the univariate analysis for OS, alcohol consumption, CRT agent, NLR, MLR, PLR, SII and PNI were found as prognostic factors. Also alcohol consumption was found as an independent prognostic factor in multivariate analyzes HR:5.201, 95 CI:1.9-14.2, p0.01. Conclusion: In our study, high SII and low PNI values were not found to be independent poor prognostic factors for OS, but lower OS rates were observed in patients with high SII and low PNI values.

Makale detayları

The relationship between systemic immune-inflammation indexes and treatment response in locally advanced esophageal cancer

Yazarlar: Esra Kekilli | Ebru Atasever Akkaş | Serab Uyar | Emre Yekedüz

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Anatolian Current Medical Journal Vol.5 Issue 1, pp.53-58

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001282647

pISSN: 2718-0115

Esophageal cancer

treatment response

systemic immune-inflammation index

Esophageal cancer

treatment response

systemic immune-inflammation index

Sayı

Yazarlar:

Esra Kekilli | Ebru Atasever Akkaş | Serab Uyar | Emre Yekedüz

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 1, pp.53-58

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282647

pISSN:

2718-0115