Recent advances in the immunology and uterine microbiology of healthy cows and cows that develop uterine disease

Klibs N. GALVAO; Jose Eduardo P. SANTOS

Makale detayları

Recent advances in the immunology and uterine microbiology of healthy cows and cows that develop uterine disease

Yazarlar:

Klibs N. GALVAO | Jose Eduardo P. SANTOS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2014 Vol.38 Issue 6, pp.577-588

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000765751

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

Uterine diseases are highly prevalent in dairy cows. Causes of uterine diseases are multifactorial. There is good evidence for the susceptibility of the host and for the role of pathogenic bacteria, and less evidence for the effect of the environment. Uterine and leukocyte immune response is impaired early postpartum in cows that develop uterine disease. The decrease in immune function is associated with a decrease in calcium postpartum and an increase in NEFA and BHBA. Both endometrial cells and granulosal cells possess toll-like receptors (TLR) that can recognize and mount an inflammatory response to pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides (LPSs) or lipopeptides. Exposure to LPSs leads to endocrine dysregulation, which may affect steroidogenesis, ovulation and luteolysis. Some E. coli possess specific virulence factors such as fimH, hlyA, cdt, kpsMII, ibeA, and astA that cause uterine disease in dairy cows. These E. coli are associated with the occurrence of other pathogenic bacteria such as A. pyogenes, F. necrophorum, and Bacteroides spp., which act synergistically to cause uterine disease. The combined effect of bacterial infection and activation of inflammation is damage to the endometrium and embryo, delayed ovulation, shortened or extended luteal phase, and decreased fertility.

 

Uterine diseases are highly prevalent in dairy cows. Causes of uterine diseases are multifactorial. There is good evidence for the susceptibility of the host and for the role of pathogenic bacteria, and less evidence for the effect of the environment. Uterine and leukocyte immune response is impaired early postpartum in cows that develop uterine disease. The decrease in immune function is associated with a decrease in calcium postpartum and an increase in NEFA and BHBA. Both endometrial cells and granulosal cells possess toll-like receptors (TLR) that can recognize and mount an inflammatory response to pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides (LPSs) or lipopeptides. Exposure to LPSs leads to endocrine dysregulation, which may affect steroidogenesis, ovulation and luteolysis. Some E. coli possess specific virulence factors such as fimH, hlyA, cdt, kpsMII, ibeA, and astA that cause uterine disease in dairy cows. These E. coli are associated with the occurrence of other pathogenic bacteria such as A. pyogenes, F. necrophorum, and Bacteroides spp., which act synergistically to cause uterine disease. The combined effect of bacterial infection and activation of inflammation is damage to the endometrium and embryo, delayed ovulation, shortened or extended luteal phase, and decreased fertility.

Makale detayları

Recent advances in the immunology and uterine microbiology of healthy cows and cows that develop uterine disease

Yazarlar:

Klibs N. GALVAO | Jose Eduardo P. SANTOS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2014 Vol.38 Issue 6, pp.577-588

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000765751

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Immune function

uterine pathogens

uterine diseases

dairy cows

Sayı

Makale detayları

Recent advances in the immunology and uterine microbiology of healthy cows and cows that develop uterine disease

Yazarlar: Klibs N. GALVAO | Jose Eduardo P. SANTOS

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2014 Vol.38 Issue 6, pp.577-588

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000765751

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Immune function

uterine pathogens

uterine diseases

dairy cows

Sayı

Yazarlar:

Klibs N. GALVAO | Jose Eduardo P. SANTOS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2014 Vol.38 Issue 6, pp.577-588

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000765751

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128