Assesment of PTCH1 promoter methylation in BCC carcinogenesis

Derya SAYIN KOCAKAP

Makale detayları

Assesment of PTCH1 promoter methylation in BCC carcinogenesis

Yazarlar:

Derya SAYIN KOCAKAP

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2014 Vol.19 Issue 2, pp.105-106

Belge Tipi:

Makale

Yayın Tarihi:

12/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000772664

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883

Özet:

 


Basal Cell Carcinoma (BCC) is the most common cancer in humans. It is known that PTCH1 mutations in Sonic Hedgehog pathway play significant role in BCC  pathogenesis. However  PTCH1 (Patched) inactivation through promoter methylation is still under investigation. In this study promoter methylation of the PTCH1 gene was analysed by Combined Bisulphite Restriction Analysis in 10 formalin-fixed paraffin-embedded (FFPE) BCC tissues. There was no methylation in any of the samples. Results suggest that PTCH1 promoter methylation is not effective in BCC carcinogenesis and FFPE tissues are not suitable for methylation analysis since 44 specimens were included in the study and only 10 of them gave result.

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Makale detayları

Assesment of PTCH1 promoter methylation in BCC carcinogenesis

Yazarlar: Derya SAYIN KOCAKAP

Yayıncı: Van Yuzuncu Yıl University

Dergi: EASTERN JOURNAL OF MEDICINE 2014 Vol.19 Issue 2, pp.105-106

Belge Tipi: Makale

Yayın Tarihi: 12/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000772664

Sıklık: Aylık

eISSN: 1301-0883

pISSN: 1301-0883

Sayı

Yazarlar:

Derya SAYIN KOCAKAP

Yayıncı:

Van Yuzuncu Yıl University

Dergi:

EASTERN JOURNAL OF MEDICINE 2014 Vol.19 Issue 2, pp.105-106

Belge Tipi:

Makale

Yayın Tarihi:

12/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000772664

Sıklık:

Aylık

eISSN:

1301-0883

pISSN:

1301-0883