APPLYING THE EXPOSOME CONCEPT IN STUDIES OF OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES

Jelle VLAANDEREN

Makale detayları

APPLYING THE EXPOSOME CONCEPT IN STUDIES OF OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES

Yazarlar:

Jelle VLAANDEREN

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-80

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835266

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711

Özet:

 


The “exposome”
concept encompasses the totality of environmental (non-genetic) exposures from
conception onwards, complementing the genome. 
Developments following the introduction of the exposome concept offer
unprecedented opportunities for discovery of the causes and mechanisms of
disease. New technologies such as the so-called “OMICS” biomonitoring
approaches, but also the inventive use of existing exposure data can contribute
to defining and measuring the exposome. Challenges in developing the exposome
concept into a workable approach for epidemiological research include the
integration of exposure uncertainty and variability, the integration of omics
techniques, and the development of statistical techniques that can analyze the
associations between exposome data and adverse health end points. Various
European projects (e.g. ExposOmics, Helix) have started to implement the
exposome, promising more integrated, holistic, ways of studying the environment
over the life course. I will present examples from studies of both occupational
and environmental exposures in which we applied the exposome concept, will
discuss which difficulties we encountered, and will highlight where further
research is needed. 

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Makale detayları

APPLYING THE EXPOSOME CONCEPT IN STUDIES OF OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES

Yazarlar: Jelle VLAANDEREN

Yayıncı: Engin TUTKUN

Dergi: The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-80

Belge Tipi: Makale

Yayın Tarihi: 2/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000835266

Sıklık: Üç Aylık

eISSN: 2149-4711

pISSN: 2149-4711

Sayı

Yazarlar:

Jelle VLAANDEREN

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-80

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835266

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711