The Effect of Halothane on the Enzymatic Activity of Mouse Liver and Erythrocyte Glucose-6- Phosphate Dehydrogenase

Ergül BELGE

Makale detayları

The Effect of Halothane on the Enzymatic Activity of Mouse Liver and Erythrocyte Glucose-6- Phosphate Dehydrogenase

Yazarlar:

Ergül BELGE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 3, pp.219-222

Belge Tipi:

Makale

Yayın Tarihi:

2/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757609

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The effects of repeated halothane  anaesthesia on 6-10 week old male, Mus  musculus albino mice weighing 29-32 g were  studied. Halothane, a widely used  anaesthetic, is known to be metabolised in  the liver to toxic intermediates through  cytochrome P4502E1 (CYP2E1). During the  first week of repeated dosage, glucose-6-  phosphate dehydrogenase (G6PDH) activity  decreased in both erythrocytes and liver cells,  and during this time, livers increased  significantly in weight and suffered  histopathological damage, the damage  increasing with the dosage of halothane, in  the range 0.25-1.0 ml twice daily. When  repeated anaesthesia was continued for a  second week, G6PDH activity increased  significantly and histopathological damage to  the liver showed no further increase. Human  and mouse G6PDH show homology, and  further work to examine the parameters  controlling the eventual increase of enzyme  activity in response to insult by halothane and  its metabolites would be worth while.

 

The effects of repeated halothane  anaesthesia on 6-10 week old male, Mus  musculus albino mice weighing 29-32 g were  studied. Halothane, a widely used  anaesthetic, is known to be metabolised in  the liver to toxic intermediates through  cytochrome P4502E1 (CYP2E1). During the  first week of repeated dosage, glucose-6-  phosphate dehydrogenase (G6PDH) activity  decreased in both erythrocytes and liver cells,  and during this time, livers increased  significantly in weight and suffered  histopathological damage, the damage  increasing with the dosage of halothane, in  the range 0.25-1.0 ml twice daily. When  repeated anaesthesia was continued for a  second week, G6PDH activity increased  significantly and histopathological damage to  the liver showed no further increase. Human  and mouse G6PDH show homology, and  further work to examine the parameters  controlling the eventual increase of enzyme  activity in response to insult by halothane and  its metabolites would be worth while.

Makale detayları

The Effect of Halothane on the Enzymatic Activity of Mouse Liver and Erythrocyte Glucose-6- Phosphate Dehydrogenase

Yazarlar:

Ergül BELGE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 3, pp.219-222

Belge Tipi:

Makale

Yayın Tarihi:

2/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757609

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Halothane

G6PDH

RBC

liver.

Sayı

Makale detayları

The Effect of Halothane on the Enzymatic Activity of Mouse Liver and Erythrocyte Glucose-6- Phosphate Dehydrogenase

Yazarlar: Ergül BELGE

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 3, pp.219-222

Belge Tipi: Makale

Yayın Tarihi: 2/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000757609

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Halothane

G6PDH

RBC

liver.

Sayı

Yazarlar:

Ergül BELGE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 3, pp.219-222

Belge Tipi:

Makale

Yayın Tarihi:

2/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757609

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144