The relationship between ghrelin and ghrelin leu72met polymorphism in coronary artery disease

Hatice Yıldırım Yaroğlu; Buğra Özkan; Senay Balcı; Zeynep Nil Ünal; Sema Erden Ertürk; Dilek	çiçek Dilek	çiçek; Lülüfer Tamer

Makale detayları

The relationship between ghrelin and ghrelin leu72met polymorphism in coronary artery disease

Yazarlar:

Hatice Yıldırım Yaroğlu | Buğra Özkan | Senay Balcı | Zeynep Nil Ünal | Sema Erden Ertürk | Dilek çiçek Dilek çiçek | Lülüfer Tamer

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 2, pp.637-643

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286360

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: Ghrelin represents a hormone, which is defined as an endogenous ligand bound to the growth hormone-releasing hormone receptor GHS-R1a. However, the mechanisms that underlie ghrelins impacts on cardiovascular diseases have not been completely detected. For this reason, we aimed to research the relationship between serum ghrelin and ghrelin gene polymorphism in coronary artery disease CAD. Materials and Methods: The study group consisted of 88 patients diagnosed with a minimum of one coronary artery stenosis over 70, and the control group comprised 81 individuals without coronary artery lesions. An autoanalyzer was used to analyze fasting blood glucose FBG and lipid parameter levels. Ghrelin levels were examined with an enzyme-linked immunosorbent assay ELISA kit. Results: Ghrelin levels were found to be 2.2 ngml in the control group and 2.1 ngml in the CAD group. No statistical relation in ghrelin Leu72Met genotypes were detected between the control and patient groups. Conclusion: Serum ghrelin levels were higher in the control group than in the CAD group. Whether ghrelin levels and Leu72Met polymorphism have protective effects in CAD must be revealed in an extensive study group with other polymorphisms and ghrelin expression in the ghrelin gene.

 Purpose: Ghrelin represents a hormone, which is defined as an endogenous ligand bound to the growth hormone-releasing hormone receptor GHS-R1a. However, the mechanisms that underlie ghrelins impacts on cardiovascular diseases have not been completely detected. For this reason, we aimed to research the relationship between serum ghrelin and ghrelin gene polymorphism in coronary artery disease CAD. Materials and Methods: The study group consisted of 88 patients diagnosed with a minimum of one coronary artery stenosis over 70, and the control group comprised 81 individuals without coronary artery lesions. An autoanalyzer was used to analyze fasting blood glucose FBG and lipid parameter levels. Ghrelin levels were examined with an enzyme-linked immunosorbent assay ELISA kit. Results: Ghrelin levels were found to be 2.2 ngml in the control group and 2.1 ngml in the CAD group. No statistical relation in ghrelin Leu72Met genotypes were detected between the control and patient groups. Conclusion: Serum ghrelin levels were higher in the control group than in the CAD group. Whether ghrelin levels and Leu72Met polymorphism have protective effects in CAD must be revealed in an extensive study group with other polymorphisms and ghrelin expression in the ghrelin gene.

 Purpose: Ghrelin represents a hormone, which is defined as an endogenous ligand bound to the growth hormone-releasing hormone receptor GHS-R1a. However, the mechanisms that underlie ghrelins impacts on cardiovascular diseases have not been completely detected. For this reason, we aimed to research the relationship between serum ghrelin and ghrelin gene polymorphism in coronary artery disease CAD. Materials and Methods: The study group consisted of 88 patients diagnosed with a minimum of one coronary artery stenosis over 70, and the control group comprised 81 individuals without coronary artery lesions. An autoanalyzer was used to analyze fasting blood glucose FBG and lipid parameter levels. Ghrelin levels were examined with an enzyme-linked immunosorbent assay ELISA kit. Results: Ghrelin levels were found to be 2.2 ngml in the control group and 2.1 ngml in the CAD group. No statistical relation in ghrelin Leu72Met genotypes were detected between the control and patient groups. Conclusion: Serum ghrelin levels were higher in the control group than in the CAD group. Whether ghrelin levels and Leu72Met polymorphism have protective effects in CAD must be revealed in an extensive study group with other polymorphisms and ghrelin expression in the ghrelin gene.

 Amaç: Ghrelin, büyüme hormonu salgılayan hormon reseptörüne GHS-R1a bağlı endojen bir ligand olarak tanımlanan bir hormondur. Bununla birlikte, ghrelinin kardiyovasküler hastalıklar üzerindeki etkilerinin altında yatan mekanizmalar tam olarak tespit edilememiştir. Bu nedenle koroner arter hastalığında KAH serum ghrelin düzeyleri ile ghrelin gen polimorfizmi arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 70in üzerinde en az bir koroner arter stenozu olan 88 hasta ve koroner arter lezyonu olmayan 81 birey dahil edildi. Açlık kan şekeri AKŞ ve lipid parametreleri düzeylerini analiz etmek için otoanalizör kullanıldı. Ghrelin düzeyleri enzim-ilişkili immunosorbent assay ELISA kiti ile çalışıldı. Bulgular: Ghrelin düzeyleri kontrol grubunda 2,2 ngml,KAH grubunda 2,1 ngml olarak bulundu. Kontrol ve hasta grupları arasında ghrelin Leu72Met genotiplerinde istatistiksel bir ilişki saptanmadı. Sonuç: Serum ghrelin düzeyleri kontrol grubunda KAH grubuna göre daha yüksek bulundu. Ghrelin düzeylerinin ve Leu72Met polimorfizminin KAHda koruyucu etkisinin olup olmadığı, diğer polimorfizmler ve ghrelin genindeki ghrelin ekspresyonu ile kapsamlı bir çalışma grubunda ortaya konmalıdır.

Makale detayları

The relationship between ghrelin and ghrelin leu72met polymorphism in coronary artery disease

Yazarlar:

Hatice Yıldırım Yaroğlu | Buğra Özkan | Senay Balcı | Zeynep Nil Ünal | Sema Erden Ertürk | Dilek çiçek Dilek çiçek | Lülüfer Tamer

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 2, pp.637-643

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286360

pISSN:

2602-3032

Ghrelin

Coronary artery disease

Leu72Met

polymorphism

Ghrelin

koroner arter hastalığı

leu72met

polimorfizm

Sayı

Makale detayları

Yazarlar: Hatice Yıldırım Yaroğlu | Buğra Özkan | Senay Balcı | Zeynep Nil Ünal | Sema Erden Ertürk | Dilek çiçek Dilek çiçek | Lülüfer Tamer

Yayıncı: Cukurova University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Cukurova Medical Journal Vol.48 Issue 2, pp.637-643

Belge Tipi: Makale

Yayın Tarihi: 2/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286360

pISSN: 2602-3032

Sayı

Yazarlar:

Hatice Yıldırım Yaroğlu | Buğra Özkan | Senay Balcı | Zeynep Nil Ünal | Sema Erden Ertürk | Dilek çiçek Dilek çiçek | Lülüfer Tamer

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 2, pp.637-643

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286360

pISSN:

2602-3032